ID   IQCC_BOVIN              Reviewed;         468 AA.
AC   Q2TBI7; Q58DC6;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   25-MAY-2022, entry version 58.
DE   RecName: Full=IQ domain-containing protein C;
GN   Name=IQCC;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q2TBI7-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q2TBI7-2; Sequence=VSP_024175;
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BT021671; AAX46518.1; -; mRNA.
DR   EMBL; BC110130; AAI10131.1; -; mRNA.
DR   RefSeq; NP_001019663.1; NM_001024492.1.
DR   AlphaFoldDB; Q2TBI7; -.
DR   STRING; 9913.ENSBTAP00000040857; -.
DR   PaxDb; Q2TBI7; -.
DR   PRIDE; Q2TBI7; -.
DR   GeneID; 507606; -.
DR   KEGG; bta:507606; -.
DR   CTD; 55721; -.
DR   eggNOG; ENOG502S8YC; Eukaryota.
DR   InParanoid; Q2TBI7; -.
DR   OrthoDB; 868750at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR042506; IQCC.
DR   PANTHER; PTHR16049; PTHR16049; 1.
DR   PROSITE; PS50096; IQ; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Reference proteome.
FT   CHAIN           1..468
FT                   /note="IQ domain-containing protein C"
FT                   /id="PRO_0000282544"
FT   DOMAIN          6..35
FT                   /note="IQ"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   REGION          113..157
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          202..245
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          329..468
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        113..132
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        133..149
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        408..432
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         1..62
FT                   /note="MERERLVLKVTALQACIRGFLVRRQFQSLRGEYEAIVQEIEGDLGTLQWTEG
FT                   WIPRPRFLPK -> MLNQNVQILGGFSLGALTPLISQ (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:16305752"
FT                   /id="VSP_024175"
FT   CONFLICT        147
FT                   /note="K -> M (in Ref. 1; AAX46518)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        215
FT                   /note="E -> D (in Ref. 1; AAX46518)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        272
FT                   /note="I -> T (in Ref. 1; AAX46518)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        399
FT                   /note="D -> A (in Ref. 1; AAX46518)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   468 AA;  52759 MW;  07E5CE029D34095E CRC64;
     MERERLVLKV TALQACIRGF LVRRQFQSLR GEYEAIVQEI EGDLGTLQWT EGWIPRPRFL
     PKKAKSCQTW KATGERAPNP EQELWSRFAC KETEKETIRE DMILKKSGES FTNASSLPCR
     DASAWSQDEQ SRRTGKPSQE TRDVSRKNDP EAAGPGLFHS QTELQELQNH RSHLAMELLW
     LQQAINSRKE YLVLKQTLRS PEVNQNRHEP SLCQEHGGQS CEKAGSQPGP PLEDQPYRGR
     TPGEPGHVDA SCWRLRSQAH KFPEGLATPD KITAGAKYRD PSYRWPGPQL PTLSEYQATG
     KRLTKELDCG EEISGETCLQ LTTLLEDESH KELKSKGSCP GKARTQLPTL HKDPNIEDNS
     PRGPCPKELD WQRAVPQELG VSEDHVTWDG SLAEHGGLDL WKNKPPKGQT PSDKSSIERS
     PSESSHEGWQ NQRAVPFRSR PPEKLSTGSG HTGEDHWRGR QWKTGPAG