IQCC_HUMAN
ID IQCC_HUMAN Reviewed; 466 AA.
AC Q4KMZ1; F5H7T8; Q4KMS3; Q4KMZ5; Q53FL2; Q5TFJ8; Q9NVS3;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 03-APR-2007, sequence version 2.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=IQ domain-containing protein C;
GN Name=IQCC;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 1-433 (ISOFORM 3).
RC TISSUE=Caudate nucleus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT CYS-209.
RC TISSUE=Synovium;
RA Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y.,
RA Tanaka A., Yokoyama S.;
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANTS
RP TYR-217 AND LEU-464.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-438, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- INTERACTION:
CC Q4KMZ1; Q8TD31-3: CCHCR1; NbExp=3; IntAct=EBI-12206419, EBI-10175300;
CC Q4KMZ1; O75031: HSF2BP; NbExp=3; IntAct=EBI-12206419, EBI-7116203;
CC Q4KMZ1; Q14145: KEAP1; NbExp=3; IntAct=EBI-12206419, EBI-751001;
CC Q4KMZ1; Q2NL68: PROSER3; NbExp=3; IntAct=EBI-12206419, EBI-11336487;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q4KMZ1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q4KMZ1-2; Sequence=VSP_024176;
CC Name=3;
CC IsoId=Q4KMZ1-3; Sequence=VSP_046123;
CC -!- SEQUENCE CAUTION:
CC Sequence=AK307853; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK001409; BAA91674.1; -; mRNA.
DR EMBL; AK307853; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AK223272; BAD96992.1; -; mRNA.
DR EMBL; AL049795; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC098250; AAH98250.1; -; mRNA.
DR EMBL; BC098260; AAH98260.1; -; mRNA.
DR EMBL; BC098317; AAH98317.1; -; mRNA.
DR EMBL; BC098366; AAH98366.1; -; mRNA.
DR CCDS; CCDS355.1; -. [Q4KMZ1-1]
DR CCDS; CCDS53293.1; -. [Q4KMZ1-3]
DR RefSeq; NP_001153514.1; NM_001160042.1. [Q4KMZ1-3]
DR RefSeq; NP_060604.2; NM_018134.2. [Q4KMZ1-1]
DR AlphaFoldDB; Q4KMZ1; -.
DR BioGRID; 120843; 15.
DR IntAct; Q4KMZ1; 7.
DR STRING; 9606.ENSP00000442291; -.
DR iPTMnet; Q4KMZ1; -.
DR PhosphoSitePlus; Q4KMZ1; -.
DR BioMuta; IQCC; -.
DR DMDM; 143339942; -.
DR jPOST; Q4KMZ1; -.
DR MassIVE; Q4KMZ1; -.
DR MaxQB; Q4KMZ1; -.
DR PaxDb; Q4KMZ1; -.
DR PeptideAtlas; Q4KMZ1; -.
DR PRIDE; Q4KMZ1; -.
DR ProteomicsDB; 27589; -.
DR ProteomicsDB; 62207; -. [Q4KMZ1-1]
DR ProteomicsDB; 62208; -. [Q4KMZ1-2]
DR Antibodypedia; 31251; 105 antibodies from 16 providers.
DR DNASU; 55721; -.
DR Ensembl; ENST00000291358.11; ENSP00000291358.6; ENSG00000160051.12. [Q4KMZ1-1]
DR Ensembl; ENST00000537469.2; ENSP00000442291.1; ENSG00000160051.12. [Q4KMZ1-3]
DR GeneID; 55721; -.
DR KEGG; hsa:55721; -.
DR MANE-Select; ENST00000291358.11; ENSP00000291358.6; NM_018134.3; NP_060604.2.
DR UCSC; uc001bum.3; human. [Q4KMZ1-1]
DR CTD; 55721; -.
DR DisGeNET; 55721; -.
DR GeneCards; IQCC; -.
DR HGNC; HGNC:25545; IQCC.
DR HPA; ENSG00000160051; Low tissue specificity.
DR neXtProt; NX_Q4KMZ1; -.
DR OpenTargets; ENSG00000160051; -.
DR PharmGKB; PA134868161; -.
DR VEuPathDB; HostDB:ENSG00000160051; -.
DR eggNOG; ENOG502S8YC; Eukaryota.
DR GeneTree; ENSGT00390000017195; -.
DR HOGENOM; CLU_046548_0_0_1; -.
DR InParanoid; Q4KMZ1; -.
DR OMA; FPCKEPE; -.
DR OrthoDB; 868750at2759; -.
DR PhylomeDB; Q4KMZ1; -.
DR TreeFam; TF330928; -.
DR PathwayCommons; Q4KMZ1; -.
DR SignaLink; Q4KMZ1; -.
DR BioGRID-ORCS; 55721; 37 hits in 1079 CRISPR screens.
DR GenomeRNAi; 55721; -.
DR Pharos; Q4KMZ1; Tdark.
DR PRO; PR:Q4KMZ1; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q4KMZ1; protein.
DR Bgee; ENSG00000160051; Expressed in vena cava and 200 other tissues.
DR Genevisible; Q4KMZ1; HS.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR042506; IQCC.
DR PANTHER; PTHR16049; PTHR16049; 1.
DR PROSITE; PS50096; IQ; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Phosphoprotein; Reference proteome.
FT CHAIN 1..466
FT /note="IQ domain-containing protein C"
FT /id="PRO_0000282545"
FT DOMAIN 6..35
FT /note="IQ"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT REGION 105..157
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 214..233
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 238..310
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 394..466
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 106..130
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 131..149
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 238..253
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 282..296
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 416..434
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 436..450
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 438
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT VAR_SEQ 14
FT /note="Q -> QVRGRARGSQDFSFREIMGSRTWTSQRDATTFSPLTARQPLEIPAVP
FT NRAEESWDPRTPCPARPHSHHTLAPDQGNGKSLK (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_046123"
FT VAR_SEQ 231..466
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_024176"
FT VARIANT 209
FT /note="F -> C (in dbSNP:rs3903683)"
FT /evidence="ECO:0000269|Ref.2"
FT /id="VAR_031411"
FT VARIANT 217
FT /note="C -> Y (in dbSNP:rs12032332)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_031412"
FT VARIANT 464
FT /note="P -> L (in dbSNP:rs41306593)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_031413"
FT CONFLICT 201
FT /note="P -> S (in Ref. 1; BAA91674)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 466 AA; 53032 MW; 7282732CE4FA4F83 CRC64;
MEPELLVRKV SALQACVRGF LVRRQFQSLR AEYEAIVREV EGDLGTLQWT EGRIPRPRFL
PEKAKSHQTW KAGDRVANPE QGLWNHFPCE ESEGEATWEE MVLKKSGESS ANQGSLCRDH
SSWLQMKQNR KPSQEKTRDT TRMENPEATD QRLPHSQPQL QELQYHRSHL AMELLWLQQA
INSRKEYLLL KQTLRSPEAG PIREEPRVFL EHGEQACERD QSQPSAPLED QSYRDRTTGE
LEQEDDSCHR VKSPHRSPGS LATTQKNIAG AKCREPCYSK SGPPSSIPSN SQALGDRLTK
GPDDGRQTFG GTCLLQMKIL EDQTPRGLKP RNHCPRKSRT QLSALYEDSN IKEMSPRKLD
HKEPDCRTVR TQELGLSEDH IIWDGTLGGP EHSVLDLWRT KPPKGQAPTD RSSRDGTSNE
PSHEGQKKQR TIPWRSKSPE ILSSTKAGCT GEEQWRGRPW KTEPPG
