ID   IQCF1_BOVIN             Reviewed;         209 AA.
AC   Q3SYS7;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=IQ domain-containing protein F1 {ECO:0000250|UniProtKB:Q8N6M8};
GN   Name=IQCF1 {ECO:0000250|UniProtKB:Q8N6M8};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in sperm capacitation and acrosome reaction.
CC       {ECO:0000250|UniProtKB:Q9D9K8}.
CC   -!- SUBUNIT: Interacts with calmodulin. {ECO:0000250|UniProtKB:Q9D9K8}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, acrosome
CC       {ECO:0000250|UniProtKB:Q9D9K8}.
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DR   EMBL; BC103417; AAI03418.1; -; mRNA.
DR   RefSeq; NP_001069241.1; NM_001075773.1.
DR   AlphaFoldDB; Q3SYS7; -.
DR   SMR; Q3SYS7; -.
DR   STRING; 9913.ENSBTAP00000001065; -.
DR   PaxDb; Q3SYS7; -.
DR   Ensembl; ENSBTAT00000001065; ENSBTAP00000001065; ENSBTAG00000000805.
DR   GeneID; 518447; -.
DR   KEGG; bta:518447; -.
DR   CTD; 132141; -.
DR   VEuPathDB; HostDB:ENSBTAG00000000805; -.
DR   VGNC; VGNC:30254; IQCF1.
DR   eggNOG; ENOG502SR3N; Eukaryota.
DR   GeneTree; ENSGT00390000004641; -.
DR   HOGENOM; CLU_114989_0_0_1; -.
DR   InParanoid; Q3SYS7; -.
DR   OMA; HSCASRG; -.
DR   OrthoDB; 1354510at2759; -.
DR   TreeFam; TF337908; -.
DR   Proteomes; UP000009136; Chromosome 22.
DR   Bgee; ENSBTAG00000000805; Expressed in semen and 14 other tissues.
DR   GO; GO:0001669; C:acrosomal vesicle; ISS:UniProtKB.
DR   GO; GO:0005516; F:calmodulin binding; IBA:GO_Central.
DR   GO; GO:2000344; P:positive regulation of acrosome reaction; ISS:UniProtKB.
DR   GO; GO:0060474; P:positive regulation of flagellated sperm motility involved in capacitation; ISS:UniProtKB.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR039887; IQCF.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR21633; PTHR21633; 1.
DR   Pfam; PF00612; IQ; 3.
DR   SMART; SM00015; IQ; 3.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS50096; IQ; 2.
PE   2: Evidence at transcript level;
KW   Cytoplasmic vesicle; Reference proteome; Repeat.
FT   CHAIN           1..209
FT                   /note="IQ domain-containing protein F1"
FT                   /id="PRO_0000282555"
FT   DOMAIN          72..101
FT                   /note="IQ 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          128..157
FT                   /note="IQ 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   REGION          1..73
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..18
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        19..42
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        43..63
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   209 AA;  24194 MW;  EBFEC325C698C8F4 CRC64;
     METDQPKTVD ENTENKPQEN KGLVENSLPS EPSPTLEKAE AQQENKAATK GADDADKRSG
     VVTKPQKKPP VSDPEAVKIQ AWWRGTLVRR TLLHAALRVW IIQAWWRVKL ARLQDSRRRA
     ALENFTRKEW AAVRLQSWVR MWRIRRRYCR LLDAARIIQA YWRCHSCTSR GFIKGYYRVT
     ANQLHLELEI LLGSGPCIVT ECIPLPIKQ