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IQCF1_MOUSE
ID   IQCF1_MOUSE             Reviewed;         182 AA.
AC   Q9D9K8; Q810M2;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=IQ domain-containing protein F1 {ECO:0000250|UniProtKB:Q8N6M8};
GN   Name=Iqcf1 {ECO:0000312|MGI:MGI:1921517};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   STRAIN=C57BL/6J; TISSUE=Testis;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   TISSUE SPECIFICITY, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE, FUNCTION,
RP   AND INTERACTION WITH CALMODULIN.
RX   PubMed=25380116; DOI=10.1111/andr.296;
RA   Fang P., Xu W., Li D., Zhao X., Dai J., Wang Z., Yan X., Qin M., Zhang Y.,
RA   Xu C., Wang L., Qiao Z.;
RT   "A novel acrosomal protein, IQCF1, involved in sperm capacitation and the
RT   acrosome reaction.";
RL   Andrology 3:332-344(2015).
CC   -!- FUNCTION: Involved in sperm capacitation and acrosome reaction.
CC       {ECO:0000269|PubMed:25380116}.
CC   -!- SUBUNIT: Interacts with calmodulin. {ECO:0000269|PubMed:25380116}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, acrosome
CC       {ECO:0000269|PubMed:25380116}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q9D9K8-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9D9K8-2; Sequence=VSP_024186;
CC   -!- TISSUE SPECIFICITY: Specifically expressed in testes and mature
CC       spermatozoa (at protein level). {ECO:0000269|PubMed:25380116}.
CC   -!- DISRUPTION PHENOTYPE: Homozygote Iqcf1 mice are significantly less
CC       fertile because of reduced sperm motility and acrosome reaction.
CC       {ECO:0000269|PubMed:25380116}.
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DR   EMBL; AK006797; BAB24744.1; -; mRNA.
DR   EMBL; BC049769; AAH49769.1; -; mRNA.
DR   CCDS; CCDS52910.1; -. [Q9D9K8-1]
DR   CCDS; CCDS52911.1; -. [Q9D9K8-2]
DR   RefSeq; NP_001140173.1; NM_001146701.1. [Q9D9K8-2]
DR   RefSeq; NP_083119.1; NM_028843.1. [Q9D9K8-1]
DR   AlphaFoldDB; Q9D9K8; -.
DR   SMR; Q9D9K8; -.
DR   STRING; 10090.ENSMUSP00000082195; -.
DR   iPTMnet; Q9D9K8; -.
DR   PhosphoSitePlus; Q9D9K8; -.
DR   PaxDb; Q9D9K8; -.
DR   PRIDE; Q9D9K8; -.
DR   ProteomicsDB; 267003; -. [Q9D9K8-1]
DR   ProteomicsDB; 267004; -. [Q9D9K8-2]
DR   Antibodypedia; 31058; 119 antibodies from 19 providers.
DR   Ensembl; ENSMUST00000085114; ENSMUSP00000082195; ENSMUSG00000066383. [Q9D9K8-1]
DR   Ensembl; ENSMUST00000164965; ENSMUSP00000126039; ENSMUSG00000066383. [Q9D9K8-2]
DR   GeneID; 74267; -.
DR   KEGG; mmu:74267; -.
DR   UCSC; uc009rkc.2; mouse. [Q9D9K8-1]
DR   UCSC; uc009rkd.2; mouse. [Q9D9K8-2]
DR   CTD; 132141; -.
DR   MGI; MGI:1921517; Iqcf1.
DR   VEuPathDB; HostDB:ENSMUSG00000066383; -.
DR   eggNOG; ENOG502SR3N; Eukaryota.
DR   GeneTree; ENSGT00390000004641; -.
DR   HOGENOM; CLU_114989_0_0_1; -.
DR   InParanoid; Q9D9K8; -.
DR   OMA; HSCASRG; -.
DR   OrthoDB; 1354510at2759; -.
DR   PhylomeDB; Q9D9K8; -.
DR   TreeFam; TF337908; -.
DR   BioGRID-ORCS; 74267; 0 hits in 72 CRISPR screens.
DR   PRO; PR:Q9D9K8; -.
DR   Proteomes; UP000000589; Chromosome 9.
DR   RNAct; Q9D9K8; protein.
DR   Bgee; ENSMUSG00000066383; Expressed in seminiferous tubule of testis and 11 other tissues.
DR   ExpressionAtlas; Q9D9K8; baseline and differential.
DR   Genevisible; Q9D9K8; MM.
DR   GO; GO:0001669; C:acrosomal vesicle; IDA:UniProtKB.
DR   GO; GO:0005516; F:calmodulin binding; IPI:UniProtKB.
DR   GO; GO:2000344; P:positive regulation of acrosome reaction; IMP:UniProtKB.
DR   GO; GO:0060474; P:positive regulation of flagellated sperm motility involved in capacitation; IMP:UniProtKB.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR039887; IQCF.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR21633; PTHR21633; 1.
DR   Pfam; PF00612; IQ; 3.
DR   SMART; SM00015; IQ; 3.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS50096; IQ; 2.
PE   1: Evidence at protein level;
KW   Alternative splicing; Cytoplasmic vesicle; Reference proteome; Repeat.
FT   CHAIN           1..182
FT                   /note="IQ domain-containing protein F1"
FT                   /id="PRO_0000282557"
FT   DOMAIN          45..74
FT                   /note="IQ 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          101..130
FT                   /note="IQ 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   REGION          1..43
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..16
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        27..43
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         1..36
FT                   /note="MGEEQQKPEELNAPTDDAPQEKQQPADLSSETEKAK -> M (in
FT                   isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_024186"
SQ   SEQUENCE   182 AA;  21456 MW;  ABDD7ABF1417DAEC CRC64;
     MGEEQQKPEE LNAPTDDAPQ EKQQPADLSS ETEKAKSKKK QELSEKDQVV KIQAWWRGTL
     VRRSLLHAAL SAWIIQCWWR LILPKIMEKR RQSMLDTFQQ EQWAVVRLQS WIRMWRIRRR
     YCRLLKAVRT IQSHWRGHTC SSRGVIKGQY RISTSQMHLE LEVLLGSGPC IVTECIPLPI
     KQ
 
 
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