ID   IQCF2_HUMAN             Reviewed;         164 AA.
AC   Q8IXL9;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=IQ domain-containing protein F2;
GN   Name=IQCF2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- INTERACTION:
CC       Q8IXL9; P28799: GRN; NbExp=3; IntAct=EBI-10238842, EBI-747754;
CC       Q8IXL9; O60333-2: KIF1B; NbExp=3; IntAct=EBI-10238842, EBI-10975473;
CC       Q8IXL9; Q17RB8: LONRF1; NbExp=3; IntAct=EBI-10238842, EBI-2341787;
CC       Q8IXL9; P60891: PRPS1; NbExp=3; IntAct=EBI-10238842, EBI-749195;
CC       Q8IXL9; Q9Y3C5: RNF11; NbExp=3; IntAct=EBI-10238842, EBI-396669;
CC       Q8IXL9; O76024: WFS1; NbExp=3; IntAct=EBI-10238842, EBI-720609;
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DR   EMBL; BC040047; AAH40047.1; -; mRNA.
DR   CCDS; CCDS2835.1; -.
DR   RefSeq; NP_982248.1; NM_203424.1.
DR   AlphaFoldDB; Q8IXL9; -.
DR   SMR; Q8IXL9; -.
DR   BioGRID; 132986; 30.
DR   IntAct; Q8IXL9; 6.
DR   STRING; 9606.ENSP00000329904; -.
DR   iPTMnet; Q8IXL9; -.
DR   PhosphoSitePlus; Q8IXL9; -.
DR   BioMuta; IQCF2; -.
DR   DMDM; 74728210; -.
DR   MassIVE; Q8IXL9; -.
DR   PaxDb; Q8IXL9; -.
DR   PeptideAtlas; Q8IXL9; -.
DR   PRIDE; Q8IXL9; -.
DR   Antibodypedia; 76253; 35 antibodies from 10 providers.
DR   DNASU; 389123; -.
DR   Ensembl; ENST00000333127.4; ENSP00000329904.3; ENSG00000184345.5.
DR   GeneID; 389123; -.
DR   KEGG; hsa:389123; -.
DR   MANE-Select; ENST00000333127.4; ENSP00000329904.3; NM_203424.2; NP_982248.1.
DR   UCSC; uc003dbt.2; human.
DR   CTD; 389123; -.
DR   GeneCards; IQCF2; -.
DR   HGNC; HGNC:31815; IQCF2.
DR   HPA; ENSG00000184345; Tissue enriched (testis).
DR   neXtProt; NX_Q8IXL9; -.
DR   OpenTargets; ENSG00000184345; -.
DR   PharmGKB; PA134900355; -.
DR   VEuPathDB; HostDB:ENSG00000184345; -.
DR   eggNOG; ENOG502SR3N; Eukaryota.
DR   GeneTree; ENSGT00390000004641; -.
DR   HOGENOM; CLU_114989_2_0_1; -.
DR   InParanoid; Q8IXL9; -.
DR   OMA; HMALRAW; -.
DR   OrthoDB; 1354510at2759; -.
DR   PhylomeDB; Q8IXL9; -.
DR   TreeFam; TF337908; -.
DR   PathwayCommons; Q8IXL9; -.
DR   SignaLink; Q8IXL9; -.
DR   BioGRID-ORCS; 389123; 10 hits in 1059 CRISPR screens.
DR   GenomeRNAi; 389123; -.
DR   Pharos; Q8IXL9; Tdark.
DR   PRO; PR:Q8IXL9; -.
DR   Proteomes; UP000005640; Chromosome 3.
DR   RNAct; Q8IXL9; protein.
DR   Bgee; ENSG00000184345; Expressed in left testis and 41 other tissues.
DR   Genevisible; Q8IXL9; HS.
DR   GO; GO:0005516; F:calmodulin binding; IBA:GO_Central.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR039887; IQCF.
DR   PANTHER; PTHR21633; PTHR21633; 1.
DR   Pfam; PF00612; IQ; 3.
DR   SMART; SM00015; IQ; 3.
DR   PROSITE; PS50096; IQ; 2.
PE   1: Evidence at protein level;
KW   Reference proteome; Repeat.
FT   CHAIN           1..164
FT                   /note="IQ domain-containing protein F2"
FT                   /id="PRO_0000282559"
FT   DOMAIN          43..72
FT                   /note="IQ 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          99..128
FT                   /note="IQ 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
SQ   SEQUENCE   164 AA;  19627 MW;  45931CDAF11D9F6C CRC64;
     MRVRFCTKGN LILVIIEDVE ESIEWKTLQK KKQQKIKEKL RIRTKAAVKI QAWWRGTLVR
     RTLLHAALRA WIIQCWWRMT LSRVLEKKRQ AALIAYATRE RAVIKLQSLV RMWRVRWRYC
     QVLNAIYIIQ GHWQCHNCQT CALLQGHCVV TATHLQFHIE IINS