IQCF3_HUMAN
ID IQCF3_HUMAN Reviewed; 154 AA.
AC P0C7M6; B2RUV0;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 10-JUN-2008, sequence version 1.
DT 03-AUG-2022, entry version 86.
DE RecName: Full=IQ domain-containing protein F3;
GN Name=IQCF3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC P0C7M6; Q9UHD9: UBQLN2; NbExp=3; IntAct=EBI-11953784, EBI-947187;
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DR EMBL; AK057432; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AC097636; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471055; EAW65154.1; -; Genomic_DNA.
DR EMBL; BC146874; AAI46875.1; -; mRNA.
DR EMBL; BC146889; AAI46890.1; -; mRNA.
DR EMBL; BC171811; AAI71811.1; -; mRNA.
DR EMBL; BC171818; AAI71818.1; -; mRNA.
DR CCDS; CCDS46837.1; -.
DR RefSeq; NP_001078948.1; NM_001085479.2.
DR RefSeq; NP_001193952.1; NM_001207023.1.
DR AlphaFoldDB; P0C7M6; -.
DR SMR; P0C7M6; -.
DR BioGRID; 134902; 13.
DR IntAct; P0C7M6; 1.
DR iPTMnet; P0C7M6; -.
DR PhosphoSitePlus; P0C7M6; -.
DR BioMuta; IQCF3; -.
DR DMDM; 190359730; -.
DR MassIVE; P0C7M6; -.
DR PaxDb; P0C7M6; -.
DR PeptideAtlas; P0C7M6; -.
DR PRIDE; P0C7M6; -.
DR ProteomicsDB; 52345; -.
DR DNASU; 401067; -.
DR Ensembl; ENST00000437810.7; ENSP00000409373.2; ENSG00000229972.9.
DR Ensembl; ENST00000440739.4; ENSP00000402012.2; ENSG00000229972.9.
DR Ensembl; ENST00000446775.5; ENSP00000401767.1; ENSG00000229972.9.
DR GeneID; 401067; -.
DR KEGG; hsa:401067; -.
DR MANE-Select; ENST00000440739.4; ENSP00000402012.2; NM_001393887.1; NP_001380816.1.
DR UCSC; uc021wyy.2; human.
DR CTD; 401067; -.
DR GeneCards; IQCF3; -.
DR HGNC; HGNC:31816; IQCF3.
DR HPA; ENSG00000229972; Tissue enriched (testis).
DR neXtProt; NX_P0C7M6; -.
DR OpenTargets; ENSG00000229972; -.
DR PharmGKB; PA134884625; -.
DR VEuPathDB; HostDB:ENSG00000229972; -.
DR eggNOG; ENOG502T3TE; Eukaryota.
DR GeneTree; ENSGT00390000004641; -.
DR HOGENOM; CLU_114989_2_0_1; -.
DR InParanoid; P0C7M6; -.
DR OMA; WQCHRRY; -.
DR OrthoDB; 1354510at2759; -.
DR PhylomeDB; P0C7M6; -.
DR TreeFam; TF337908; -.
DR PathwayCommons; P0C7M6; -.
DR SignaLink; P0C7M6; -.
DR BioGRID-ORCS; 401067; 11 hits in 1060 CRISPR screens.
DR GenomeRNAi; 401067; -.
DR Pharos; P0C7M6; Tdark.
DR PRO; PR:P0C7M6; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; P0C7M6; protein.
DR Bgee; ENSG00000229972; Expressed in left testis and 64 other tissues.
DR ExpressionAtlas; P0C7M6; baseline and differential.
DR Genevisible; P0C7M6; HS.
DR GO; GO:0005516; F:calmodulin binding; IBA:GO_Central.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR039887; IQCF.
DR PANTHER; PTHR21633; PTHR21633; 1.
DR Pfam; PF00612; IQ; 2.
DR SMART; SM00015; IQ; 2.
DR PROSITE; PS50096; IQ; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..154
FT /note="IQ domain-containing protein F3"
FT /id="PRO_0000339381"
FT DOMAIN 89..118
FT /note="IQ"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
SQ SEQUENCE 154 AA; 18251 MW; 92DD0D3985D804B5 CRC64;
MGSKCCKGGP DEDAVERQRR QKLLLAQLHH RKRVKAAGQI QAWWRGVLVR RTLLVAALRA
WMIQCWWRTL VQRRIRQRRQ ALLRVYVIQE QATVKLQSCI RMWQCRQCYR QMCNALCLFQ
VPESSLAFQT DGFLQVQYAI PSKQPEFHIE ILSI
