IQCH_MOUSE
ID IQCH_MOUSE Reviewed; 1071 AA.
AC Q9D2K4; G5E8B0; Q8C0X9;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2012, sequence version 3.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=IQ domain-containing protein H;
GN Name=Iqch;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=15897968; DOI=10.1111/j.1745-7262.2005.00041.x;
RA Yin L.L., Li J.M., Zhou Z.M., Sha J.H.;
RT "Identification of a novel testis-specific gene and its potential roles in
RT testis development/spermatogenesis.";
RL Asian J. Androl. 7:127-137(2005).
CC -!- FUNCTION: May play a regulatory role in spermatogenesis.
CC {ECO:0000269|PubMed:15897968}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9D2K4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9D2K4-2; Sequence=VSP_024197;
CC -!- TISSUE SPECIFICITY: Expressed in fetal and adult testis, in the
CC spermatocytes and spermatids but not in somatic cells.
CC {ECO:0000269|PubMed:15897968}.
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DR EMBL; AK019535; BAB31783.1; -; mRNA.
DR EMBL; AK029502; BAC26480.1; -; mRNA.
DR EMBL; AC122057; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CT010509; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466522; EDL26041.1; -; Genomic_DNA.
DR CCDS; CCDS81021.1; -. [Q9D2K4-1]
DR RefSeq; NP_001298027.1; NM_001311098.1. [Q9D2K4-1]
DR RefSeq; NP_084344.1; NM_030068.2.
DR AlphaFoldDB; Q9D2K4; -.
DR STRING; 10090.ENSMUSP00000047953; -.
DR PhosphoSitePlus; Q9D2K4; -.
DR PaxDb; Q9D2K4; -.
DR PRIDE; Q9D2K4; -.
DR ProteomicsDB; 268989; -. [Q9D2K4-1]
DR ProteomicsDB; 268990; -. [Q9D2K4-2]
DR Antibodypedia; 26248; 30 antibodies from 11 providers.
DR Ensembl; ENSMUST00000042322; ENSMUSP00000047953; ENSMUSG00000037801. [Q9D2K4-1]
DR Ensembl; ENSMUST00000080527; ENSMUSP00000079370; ENSMUSG00000037801. [Q9D2K4-2]
DR GeneID; 78250; -.
DR KEGG; mmu:78250; -.
DR UCSC; uc009qbd.3; mouse. [Q9D2K4-1]
DR UCSC; uc012guy.2; mouse. [Q9D2K4-2]
DR CTD; 64799; -.
DR MGI; MGI:1925500; Iqch.
DR VEuPathDB; HostDB:ENSMUSG00000037801; -.
DR eggNOG; ENOG502QSF3; Eukaryota.
DR GeneTree; ENSGT00390000008908; -.
DR InParanoid; Q9D2K4; -.
DR OMA; VNIFPKH; -.
DR OrthoDB; 203701at2759; -.
DR PhylomeDB; Q9D2K4; -.
DR TreeFam; TF328488; -.
DR BioGRID-ORCS; 78250; 2 hits in 71 CRISPR screens.
DR PRO; PR:Q9D2K4; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q9D2K4; protein.
DR Bgee; ENSMUSG00000037801; Expressed in spermatid and 8 other tissues.
DR ExpressionAtlas; Q9D2K4; baseline and differential.
DR Genevisible; Q9D2K4; MM.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR038752; IQCH.
DR PANTHER; PTHR14465; PTHR14465; 1.
DR PROSITE; PS50096; IQ; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..1071
FT /note="IQ domain-containing protein H"
FT /id="PRO_0000282566"
FT DOMAIN 406..435
FT /note="IQ"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT REGION 262..286
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 262..279
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 737..970
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_024197"
FT CONFLICT 61
FT /note="I -> V (in Ref. 1; BAB31783)"
FT /evidence="ECO:0000305"
FT CONFLICT 102
FT /note="F -> Y (in Ref. 1; BAC26480)"
FT /evidence="ECO:0000305"
FT CONFLICT 442
FT /note="A -> S (in Ref. 1; BAB31783)"
FT /evidence="ECO:0000305"
FT CONFLICT 496
FT /note="Y -> C (in Ref. 1; BAB31783)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1071 AA; 122605 MW; 002DE6EE76F9C598 CRC64;
MAQAQEDSDP IGSILIQVHE DLHQLKEKLV KFSAEETRST LDIQNLETAI QRTEMGLKIH
IDKYLGVVNQ EVLMAPVKKS LESPVTSKWS IPTVIDQKSF IFPMDSDFWR PQKHRGSLLH
GLRRAKPKIQ LTTKVMQDPE NKHHRAAVTA SYGISLPHIN QRKAQDKVQR LIKGSTISNL
TVLPPSHRTD PHFIPIPVLQ KDASKGVLSM IERGLIPPTA RITFQNPPIK PQALPLHSFD
EHRKVPMEAS FPLALKPRPV PEEVEEPSHQ IEIPKGRAKR SRGPLRRKGM KIRTPSKTRK
SPWDYIFSVY NGCVDRTAPD FLAFKSRFKL IWGSIFSFLE QIEKFLKDYA ISEAKIKGKS
LVSLLPEFEL KNKLTRNDVL AVLENPVHIQ MLLNLPGQRY KGQDGKAEAA TKIQATWKSY
KARSSFISYR QKKWASGVIA LAWLLHCHRT RLKRIVKESR QRHLENFRIR AQHLAANWSR
IRTSRRTIIH IPSLGYSQYV RKHIFDLDVE QNMQLGRLCD IIDANVNVIY ICSHPMTDEL
KLYYRKLLSL QAAVKTGYYG DRTDLQNRFR IITPEAVNVF TKHHMCLATH LMYSPKAIKR
IKNLIRGEEA YIVGGILHRD DLAVADMLNV PILGSEPELV HLYSAKSGSK RIFDNANVPM
PPGIYDIYTY QQMIEQLSQL VTDNLGIRRW VFKMNTEFGG NGTAFCDIPS HLQCYNWVLK
ERNRFGHEDW KKKWAQESAL VKISEELAGI LAQHVQLVNE KRFPTWRKFL HMFLTQGGVI
EAYPPADSVT NLTVDMLIEP DGEVRVLSMG DQLHADGPFI SSGTTMPQTS VDPQVLNSLC
LQIGNICKEK DVVGYFSIDL VTFIDPSTLE QQVWTTGLNL SYSDQLAMTQ LTLYLTNGHL
NCSLSTLEVP RFTEDSERER KRLSIQAELA PETSRYAVMS TQLKHDNLSL IFYYVFLQMC
KAHGIGYDLE DRQGTVFILY ESLKRYKLGM LTIGVDLQGV LMTFARNLFI IHQEISAPDM
QGETNFKTTI DDIETILGVT EENKMIFVRE KQSKEEEDNL YEPVEIHSEI V
