IQCJ_HUMAN
ID IQCJ_HUMAN Reviewed; 159 AA.
AC Q1A5X6; B7ZMM2; B9EH97; Q1A5X5;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 11-JUL-2006, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=IQ domain-containing protein J {ECO:0000305};
GN Name=IQCJ {ECO:0000312|HGNC:HGNC:32406};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS IQCJ-1 AND IQCJ-2), AND ALTERNATIVE
RP SPLICING.
RX PubMed=17045569; DOI=10.1016/j.bbrc.2006.09.136;
RA Kwasnicka-Crawford D.A., Carson A.R., Scherer S.W.;
RT "IQCJ-SCHIP1, a novel fusion transcript encoding a calmodulin-binding IQ
RT motif protein.";
RL Biochem. Biophys. Res. Commun. 350:890-899(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS IQCJ-1 AND IQCJ-3).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=5;
CC Name=IQCJ-1;
CC IsoId=Q1A5X6-1; Sequence=Displayed;
CC Name=IQCJ-2;
CC IsoId=Q1A5X6-2; Sequence=VSP_030597;
CC Name=IQCJ-3;
CC IsoId=Q1A5X6-3; Sequence=VSP_043259;
CC Name=IQCJ-SCHIP1-1;
CC IsoId=B3KU38-1; Sequence=External;
CC Name=IQCJ-SCHIP1-2;
CC IsoId=B3KU38-2; Sequence=External;
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DR EMBL; DQ309553; ABC26018.1; -; mRNA.
DR EMBL; DQ309554; ABC26019.1; -; mRNA.
DR EMBL; AC092997; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC092999; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC107312; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471052; EAW78670.1; -; Genomic_DNA.
DR EMBL; BC137464; AAI37465.1; -; mRNA.
DR EMBL; BC137469; AAI37470.1; -; mRNA.
DR EMBL; BC144658; AAI44659.1; -; mRNA.
DR CCDS; CCDS46946.1; -. [Q1A5X6-1]
DR CCDS; CCDS46947.1; -. [Q1A5X6-2]
DR CCDS; CCDS56290.1; -. [Q1A5X6-3]
DR RefSeq; NP_001036170.1; NM_001042705.2. [Q1A5X6-1]
DR RefSeq; NP_001036171.1; NM_001042706.2. [Q1A5X6-2]
DR RefSeq; NP_001184029.1; NM_001197100.1. [Q1A5X6-3]
DR AlphaFoldDB; Q1A5X6; -.
DR BioGRID; 576396; 1.
DR STRING; 9606.ENSP00000402153; -.
DR iPTMnet; Q1A5X6; -.
DR PhosphoSitePlus; Q1A5X6; -.
DR BioMuta; IQCJ; -.
DR DMDM; 121940648; -.
DR MassIVE; Q1A5X6; -.
DR MaxQB; Q1A5X6; -.
DR PaxDb; Q1A5X6; -.
DR PeptideAtlas; Q1A5X6; -.
DR PRIDE; Q1A5X6; -.
DR ProteomicsDB; 61199; -. [Q1A5X6-1]
DR ProteomicsDB; 61200; -. [Q1A5X6-2]
DR ProteomicsDB; 61201; -. [Q1A5X6-3]
DR Antibodypedia; 54183; 147 antibodies from 19 providers.
DR DNASU; 654502; -.
DR Ensembl; ENST00000397832.7; ENSP00000380932.2; ENSG00000214216.11. [Q1A5X6-2]
DR Ensembl; ENST00000451172.5; ENSP00000402153.1; ENSG00000214216.11. [Q1A5X6-1]
DR Ensembl; ENST00000482126.1; ENSP00000418141.1; ENSG00000214216.11. [Q1A5X6-3]
DR GeneID; 654502; -.
DR KEGG; hsa:654502; -.
DR MANE-Select; ENST00000397832.7; ENSP00000380932.2; NM_001042706.3; NP_001036171.1. [Q1A5X6-2]
DR UCSC; uc003fco.4; human. [Q1A5X6-1]
DR CTD; 654502; -.
DR DisGeNET; 654502; -.
DR GeneCards; IQCJ; -.
DR HGNC; HGNC:32406; IQCJ.
DR HPA; ENSG00000214216; Tissue enriched (brain).
DR MIM; 611622; gene.
DR neXtProt; NX_Q1A5X6; -.
DR OpenTargets; ENSG00000214216; -.
DR PharmGKB; PA143485504; -.
DR VEuPathDB; HostDB:ENSG00000214216; -.
DR eggNOG; ENOG502S3HE; Eukaryota.
DR GeneTree; ENSGT00390000000847; -.
DR HOGENOM; CLU_150757_0_0_1; -.
DR InParanoid; Q1A5X6; -.
DR OMA; KYRINLQ; -.
DR PhylomeDB; Q1A5X6; -.
DR TreeFam; TF336256; -.
DR PathwayCommons; Q1A5X6; -.
DR BioGRID-ORCS; 654502; 6 hits in 1044 CRISPR screens.
DR GenomeRNAi; 654502; -.
DR Pharos; Q1A5X6; Tdark.
DR PRO; PR:Q1A5X6; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q1A5X6; protein.
DR Bgee; ENSG00000214216; Expressed in corpus callosum and 36 other tissues.
DR InterPro; IPR029362; IQCJ-SCHIP1_N.
DR Pfam; PF15157; IQCJ-SCHIP1; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..159
FT /note="IQ domain-containing protein J"
FT /id="PRO_0000315661"
FT DOMAIN 47..67
FT /note="IQ"
FT /evidence="ECO:0000305|PubMed:17045569"
FT REGION 63..88
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 69..88
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 26..52
FT /note="Missing (in isoform IQCJ-3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_043259"
FT VAR_SEQ 98..159
FT /note="FARAPVGKIHPYISWRLQSPGDKLPGGRKVILLYLDQLARPTGFIHTLKEPQ
FT IERLGFLTLQ -> VSVMFLFLCPDLTFN (in isoform IQCJ-2)"
FT /evidence="ECO:0000303|PubMed:17045569"
FT /id="VSP_030597"
SQ SEQUENCE 159 AA; 18226 MW; 5EBF23B8E2161D3D CRC64;
MRLEELKRLQ NPLEQVNDGK YSFENHQLAM DAENNIEKYP LNLQPLESKV KIIQRAWREY
LQRQEPLGKR SPSPPSVSSE KLSSSVSMNT FSDSSTPFAR APVGKIHPYI SWRLQSPGDK
LPGGRKVILL YLDQLARPTG FIHTLKEPQI ERLGFLTLQ
