IQCK_HUMAN
ID IQCK_HUMAN Reviewed; 287 AA.
AC Q8N0W5; B2RDU0; O43327; Q8NFF4;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=IQ domain-containing protein K;
GN Name=IQCK;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Heart;
RA Chen X.G., Li Y.;
RL Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10493829; DOI=10.1006/geno.1999.5927;
RA Loftus B.J., Kim U.-J., Sneddon V.P., Kalush F., Brandon R., Fuhrmann J.,
RA Mason T., Crosby M.L., Barnstead M., Cronin L., Mays A.D., Cao Y., Xu R.X.,
RA Kang H.-L., Mitchell S., Eichler E.E., Harris P.C., Venter J.C.,
RA Adams M.D.;
RT "Genome duplications and other features in 12 Mb of DNA sequence from human
RT chromosome 16p and 16q.";
RL Genomics 60:295-308(1999).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8N0W5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8N0W5-2; Sequence=VSP_024205, VSP_024206;
CC Name=3;
CC IsoId=Q8N0W5-3; Sequence=VSP_024204, VSP_024207;
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DR EMBL; AF520569; AAM77339.1; -; mRNA.
DR EMBL; AF520570; AAM77340.1; -; mRNA.
DR EMBL; AK315672; BAG38037.1; -; mRNA.
DR EMBL; AC002550; AAC05807.1; -; Genomic_DNA.
DR EMBL; CH471186; EAW50300.1; -; Genomic_DNA.
DR EMBL; BC034823; AAH34823.1; -; mRNA.
DR CCDS; CCDS10580.1; -. [Q8N0W5-1]
DR RefSeq; NP_001292050.1; NM_001305121.1.
DR RefSeq; NP_001292051.1; NM_001305122.1.
DR RefSeq; NP_694940.1; NM_153208.2. [Q8N0W5-1]
DR RefSeq; XP_016878422.1; XM_017022933.1.
DR AlphaFoldDB; Q8N0W5; -.
DR SMR; Q8N0W5; -.
DR BioGRID; 125852; 1.
DR STRING; 9606.ENSP00000324901; -.
DR iPTMnet; Q8N0W5; -.
DR PhosphoSitePlus; Q8N0W5; -.
DR BioMuta; IQCK; -.
DR DMDM; 74728470; -.
DR MassIVE; Q8N0W5; -.
DR PaxDb; Q8N0W5; -.
DR PeptideAtlas; Q8N0W5; -.
DR PRIDE; Q8N0W5; -.
DR ProteomicsDB; 71474; -. [Q8N0W5-1]
DR ProteomicsDB; 71475; -. [Q8N0W5-2]
DR ProteomicsDB; 71476; -. [Q8N0W5-3]
DR Antibodypedia; 12111; 72 antibodies from 17 providers.
DR DNASU; 124152; -.
DR Ensembl; ENST00000308214.13; ENSP00000309261.9; ENSG00000174628.16. [Q8N0W5-2]
DR Ensembl; ENST00000320394.10; ENSP00000324901.6; ENSG00000174628.16. [Q8N0W5-1]
DR GeneID; 124152; -.
DR KEGG; hsa:124152; -.
DR UCSC; uc002dgr.4; human. [Q8N0W5-1]
DR CTD; 124152; -.
DR DisGeNET; 124152; -.
DR GeneCards; IQCK; -.
DR HGNC; HGNC:28556; IQCK.
DR HPA; ENSG00000174628; Low tissue specificity.
DR neXtProt; NX_Q8N0W5; -.
DR NIAGADS; ENSG00000174628; -.
DR OpenTargets; ENSG00000174628; -.
DR PharmGKB; PA145148697; -.
DR VEuPathDB; HostDB:ENSG00000174628; -.
DR eggNOG; ENOG502RYCY; Eukaryota.
DR GeneTree; ENSGT00390000007907; -.
DR HOGENOM; CLU_059086_0_0_1; -.
DR InParanoid; Q8N0W5; -.
DR OMA; EICKEFA; -.
DR OrthoDB; 1262667at2759; -.
DR PhylomeDB; Q8N0W5; -.
DR TreeFam; TF336038; -.
DR PathwayCommons; Q8N0W5; -.
DR BioGRID-ORCS; 124152; 8 hits in 1025 CRISPR screens.
DR ChiTaRS; IQCK; human.
DR GenomeRNAi; 124152; -.
DR Pharos; Q8N0W5; Tdark.
DR PRO; PR:Q8N0W5; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; Q8N0W5; protein.
DR Bgee; ENSG00000174628; Expressed in bronchial epithelial cell and 203 other tissues.
DR ExpressionAtlas; Q8N0W5; baseline and differential.
DR Genevisible; Q8N0W5; HS.
DR InterPro; IPR043408; IQCK.
DR PANTHER; PTHR34927; PTHR34927; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..287
FT /note="IQ domain-containing protein K"
FT /id="PRO_0000282574"
FT VAR_SEQ 159..209
FT /note="RKRTKFIACDFLTEWLYNQNPKRAGEPFTEFFSIPFVEERLKQHPRPPIPL
FT -> VSCLAGFLYFEILNHSLLSDDSSLSWYHQVVLQMTPSGGKACVWGHLPSSSHTI
FT (in isoform 3)"
FT /evidence="ECO:0000305"
FT /id="VSP_024204"
FT VAR_SEQ 159..189
FT /note="RKRTKFIACDFLTEWLYNQNPKRAGEPFTEF -> PTAANPTLAPADRRGSS
FT PLHSILLESLCGSL (in isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_024205"
FT VAR_SEQ 190..287
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_024206"
FT VAR_SEQ 210..287
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000305"
FT /id="VSP_024207"
FT VARIANT 220
FT /note="L -> P (in dbSNP:rs7191155)"
FT /id="VAR_031416"
SQ SEQUENCE 287 AA; 33292 MW; E921F546356BCFD8 CRC64;
MAAPRQIPSH IVRLKPSCST DSSFTRTPVP TVSLASRELP VSSWQVTEPS SKNLWEQICK
EYEAEQPPFP EGYKVKQEPV ITVAPVEEML FHGFSAEHYF PVSHFTMISR TPCPQDKSET
INPKTCSPKE YLETFIFPVL LPGMASLLHQ AKKEKCFERK RTKFIACDFL TEWLYNQNPK
RAGEPFTEFF SIPFVEERLK QHPRPPIPLS LLLTEEEAAL YIQSFWRACV VRCDPEIQEL
RQWQKKLREA KHIHQQVKIF WAKQEQKVKC KMEDDAVPAA KMKIPSS