ID   IQCM_HUMAN              Reviewed;         501 AA.
AC   A0A1B0GVH7;
DT   27-SEP-2017, integrated into UniProtKB/Swiss-Prot.
DT   05-OCT-2016, sequence version 1.
DT   03-AUG-2022, entry version 31.
DE   RecName: Full=IQ domain-containing protein M {ECO:0000305};
GN   Name=IQCM {ECO:0000312|HGNC:HGNC:53443};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA   Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA   Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA   Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA   Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA   Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA   Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA   Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA   Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA   Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA   Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA   Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA   Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA   Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA   Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA   Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT   4.";
RL   Nature 434:724-731(2005).
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DR   EMBL; AC027058; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC093893; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC096756; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC097465; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC108168; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC108932; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS87270.1; -.
DR   RefSeq; XP_016864392.1; XM_017008903.1.
DR   RefSeq; XP_016883815.1; XM_017028326.1.
DR   AlphaFoldDB; A0A1B0GVH7; -.
DR   BioMuta; IQCM; -.
DR   MassIVE; A0A1B0GVH7; -.
DR   DNASU; 285423; -.
DR   Ensembl; ENST00000636793.2; ENSP00000490518.1; ENSG00000234828.9.
DR   GeneID; 285423; -.
DR   MANE-Select; ENST00000636793.2; ENSP00000490518.1; NM_001363507.2; NP_001350436.1.
DR   CTD; 285423; -.
DR   DisGeNET; 285423; -.
DR   GeneCards; IQCM; -.
DR   HGNC; HGNC:53443; IQCM.
DR   HPA; ENSG00000234828; Tissue enriched (testis).
DR   neXtProt; NX_A0A1B0GVH7; -.
DR   OpenTargets; ENSG00000234828; -.
DR   VEuPathDB; HostDB:ENSG00000234828; -.
DR   GeneTree; ENSGT00390000010038; -.
DR   OMA; YKSCKVE; -.
DR   OrthoDB; 819604at2759; -.
DR   PathwayCommons; A0A1B0GVH7; -.
DR   SignaLink; A0A1B0GVH7; -.
DR   BioGRID-ORCS; 285423; 0 hits in 23 CRISPR screens.
DR   GenomeRNAi; 285423; -.
DR   Pharos; A0A1B0GVH7; Tdark.
DR   PRO; PR:A0A1B0GVH7; -.
DR   Proteomes; UP000005640; Chromosome 4.
DR   RNAct; A0A1B0GVH7; protein.
DR   Bgee; ENSG00000234828; Expressed in colonic epithelium and 21 other tissues.
DR   ExpressionAtlas; A0A1B0GVH7; baseline and differential.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   SMART; SM00015; IQ; 1.
DR   PROSITE; PS50096; IQ; 1.
PE   4: Predicted;
KW   Reference proteome.
FT   CHAIN           1..501
FT                   /note="IQ domain-containing protein M"
FT                   /id="PRO_0000441625"
FT   DOMAIN          290..319
FT                   /note="IQ"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   REGION          237..262
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   501 AA;  59586 MW;  464C834F1B695081 CRC64;
     MTTEEAMPEK AKCPTLEITK QDFFQEAKTL IAQHYEKINE NKVQGTSINV FRKKHQKPKS
     GKYIPLEIDK KVTRDVVQEH RAALRRICFP KELSKSEHLQ EPPQRISFKE PHIFSRRERC
     RPIDLITKGQ VKLDKIMTII EPVSKKMETA KQQHFEESRN RMLELLYPFP VHLYLQPGTS
     NLELLKEPDK AFYDWRGFVL TRSFRLACDS RRVSFSQSSS IFRDYYSKTF KTLIKKERQP
     IKPEPKSQPR IKGTPNKTDK LDSKVKRIGP HIEIFQVFRE RKKFMITPKL IRMVTVMQAH
     VRGWLERKRL QRVMTKALDH GPDMKAVINM YGRLIHRVRY RRGLWRTRQI LNLAELEEWM
     DRKKFYEIMF AKREDWPKIE RNELPNFFSD CGHFPTQKQV DDTWDLVHQD GKEKYSELIK
     KSKAIEMLFT LYPPEGAHVP DSTLLKSTWL RPIVNGEEGY RYIVNGHPAL KRANIRVVGK
     LVARSIRERK MRQHYKSCKV E