IQCN_MACFA
ID IQCN_MACFA Reviewed; 1166 AA.
AC Q8WNU4; G8F647;
DT 30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 20-DEC-2017, sequence version 3.
DT 25-MAY-2022, entry version 63.
DE RecName: Full=IQ domain-containing protein N;
GN Name=IQCN; ORFNames=QtsA-12219;
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 1-1155.
RX PubMed=22002653; DOI=10.1038/nbt.1992;
RA Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N., Li Q.,
RA Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P., Huang Z.,
RA Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T., Huang Y.,
RA Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D., Li B., Liu X.,
RA Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X., Li Y., Wang W.,
RA Katze M.G., Su B., Nielsen R., Yang H., Wang J., Wang X., Wang J.;
RT "Genome sequencing and comparison of two nonhuman primate animal models,
RT the cynomolgus and Chinese rhesus macaques.";
RL Nat. Biotechnol. 29:1019-1023(2011).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 369-1166.
RC TISSUE=Testis;
RX PubMed=12498619; DOI=10.1186/1471-2164-3-36;
RA Osada N., Hida M., Kusuda J., Tanuma R., Hirata M., Suto Y., Hirai M.,
RA Terao K., Sugano S., Hashimoto K.;
RT "Cynomolgus monkey testicular cDNAs for discovery of novel human genes in
RT the human genome sequence.";
RL BMC Genomics 3:36-36(2002).
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB84026.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=EHH62761.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JH332935; EHH62761.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AB066551; BAB84026.1; ALT_INIT; mRNA.
DR AlphaFoldDB; Q8WNU4; -.
DR eggNOG; ENOG502SCUX; Eukaryota.
DR Proteomes; UP000009130; Unassembled WGS sequence.
DR Proteomes; UP000233100; Unplaced.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR040124; IQCN.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR22590:SF2; PTHR22590:SF2; 3.
DR Pfam; PF00612; IQ; 6.
DR SMART; SM00015; IQ; 6.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS50096; IQ; 6.
PE 2: Evidence at transcript level;
KW Reference proteome; Repeat.
FT CHAIN 1..1166
FT /note="IQ domain-containing protein N"
FT /id="PRO_0000050802"
FT DOMAIN 89..118
FT /note="IQ 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 907..932
FT /note="IQ 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 928..955
FT /note="IQ 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 952..979
FT /note="IQ 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1091..1119
FT /note="IQ 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1114..1143
FT /note="IQ 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT REGION 1..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 431..450
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 769..797
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 829..848
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1145..1166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..19
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 20..34
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 829..845
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 572
FT /note="A -> V (in Ref. 1; EHH62761)"
FT /evidence="ECO:0000305"
FT CONFLICT 753
FT /note="L -> R (in Ref. 1; EHH62761)"
FT /evidence="ECO:0000305"
FT CONFLICT 843
FT /note="V -> A (in Ref. 1; EHH62761)"
FT /evidence="ECO:0000305"
FT CONFLICT 979..980
FT /note="Missing (in Ref. 1; EHH62761)"
FT /evidence="ECO:0000305"
FT CONFLICT 1021
FT /note="S -> G (in Ref. 1; EHH62761)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1166 AA; 126536 MW; 311EB974AA9E40B8 CRC64;
MQPATQLQFT NHLSPNGQCI LQPPPTPSLP DKMEKAPPQP QHEGLKSEEH LPQQPAAAKT
VSRHIPRLRA VVESQAFKNI LVDEMDMMHA RAATLIQANW RGYRLRQKLI SQMTAAKAIQ
EAWRRFNKRH ILHSSKLLVK KVRAEDGNIP YHAPQQVRFQ HPEENCLLSP PVMVNKETQF
PSYDNLVLCR PQSSPLLKPP AAQGTPEPCV QAPHAAGVRG VAFLPHQTVT IRFPCPVSLD
AKCQSCLLTR TIRSTCLVHI EGDSVKTKRV TARTNKAGVP ETPLSRRYDK AVMGPSRAQT
QGPVEAETPK APFQICPGPV ITKTLLQTYP VVSMTLPQTY SASTTTTTPH KTSPVPKITI
TKTPVQMYPG PTVMTKTAPH TCPMPTMTKI QVHSTASRTG TPRQTCRATI TAKHQPQVSL
LASIMKSPPQ VCPGPAMAKT PPQTHPVATP AKSPLQTCLA ATTSNTSSQM SPVGLTKPSR
QTRLAAMITK TPAQLRSVAT ILKTLCLASP TVANVKAPPQ VAVRGSIHDN PPKAKATMNM
KQAAEAVKAS SPSCLAEGKI RCLAQSRLGT GAPRAPAKLP LEAEKIKTGP QKPVKADMAL
KTSVAVEVAG APSWTKVAEE GDKPSHLYVP VDVAVTLPRG QPAAPLTNAS SQRHPPCLSQ
RPLATPLTKA SSQGHLPIEL TKTPSLAHLV TCLSKMHSQA HLATGAMKVQ SQVPLATCLT
KTQSRGQPII TKRLIPAHQA ADLSSNTHSQ VLLTGSKVSN QACQHLSGLS APPWAKPEDR
WTQPKPHGHV PGKTTQGGPC PAACEVQGTL VPLMAPTGHS TCHVESWGDS GATRAQPSMP
SQVVPCQEDT GPVDAGVASG QSWKRVWEPA RGAASWETRR NKAVVHPRQS GEPMVSMQAA
EEIRILAVTT IQAGVRGYLV RRRIRVWHRR ATVIQATWRG YRMRRNLAHL CRATTIIQAA
WRGYSTRRDQ ARHRQMLHPV TWVELGGGAR VMSDRSWVQD GRARTVSDHR CFQSCQAKPC
SVCHSLSSRI GSPPSVVMLV GSSPRTCHTC GRTQPTRVVQ GMGRGAGGPG AVSRASAYQR
AVPSPRQPRR RDKAATAIQS AWRGFKIRQQ MRQQQMAAKM VQATWRGHHT RSCLKSTEAL
LGPADPWSSS QHMHWASSQH THWPGI
