IQD10_ARATH
ID IQD10_ARATH Reviewed; 259 AA.
AC Q9LKA0;
DT 02-JUN-2021, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 25-MAY-2022, entry version 120.
DE RecName: Full=Protein IQ-DOMAIN 10 {ECO:0000303|PubMed:16368012};
DE Short=AtIQD10 {ECO:0000303|PubMed:16368012};
GN Name=IQD10 {ECO:0000303|PubMed:16368012};
GN OrderedLocusNames=At3g15050 {ECO:0000312|Araport:AT3G15050};
GN ORFNames=K15M2.19 {ECO:0000312|EMBL:BAA97068.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10907853; DOI=10.1093/dnares/7.3.217;
RA Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 3. II. Sequence
RT features of the 4,251,695 bp regions covered by 90 P1, TAC and BAC
RT clones.";
RL DNA Res. 7:217-221(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP INTERACTION WITH CALMODULIN, GENE FAMILY, AND NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=16368012; DOI=10.1186/1471-2148-5-72;
RA Abel S., Savchenko T., Levy M.;
RT "Genome-wide comparative analysis of the IQD gene families in Arabidopsis
RT thaliana and Oryza sativa.";
RL BMC Evol. Biol. 5:72-72(2005).
RN [4]
RP SUBCELLULAR LOCATION.
RC STRAIN=cv. Columbia;
RX PubMed=28115582; DOI=10.1104/pp.16.01743;
RA Buerstenbinder K., Moeller B., Ploetner R., Stamm G., Hause G., Mitra D.,
RA Abel S.;
RT "The IQD family of calmodulin-binding proteins links calcium signaling to
RT microtubules, membrane subdomains, and the nucleus.";
RL Plant Physiol. 173:1692-1708(2017).
RN [5]
RP REVIEW.
RX PubMed=28534650; DOI=10.1080/15592324.2017.1331198;
RA Buerstenbinder K., Mitra D., Quegwer J.;
RT "Functions of IQD proteins as hubs in cellular calcium and auxin signaling:
RT A toolbox for shape formation and tissue-specification in plants?";
RL Plant Signal. Behav. 12:E1331198-E1331198(2017).
CC -!- FUNCTION: May be involved in cooperative interactions with calmodulins
CC or calmodulin-like proteins (By similarity). Recruits calmodulin
CC proteins to microtubules, thus being a potential scaffold in cellular
CC signaling and trafficking (By similarity). May associate with nucleic
CC acids and regulate gene expression at the transcriptional or post-
CC transcriptional level (By similarity). {ECO:0000250|UniProtKB:Q9SF32}.
CC -!- SUBUNIT: Binds to multiple calmodulin (CaM) in the presence of Ca(2+)
CC and CaM-like proteins. {ECO:0000250|UniProtKB:Q9SF32}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:28115582}. Cytoplasm,
CC cytoskeleton {ECO:0000269|PubMed:28115582}.
CC -!- SIMILARITY: Belongs to the IQD family. {ECO:0000305}.
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DR EMBL; AP000370; BAA97068.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE75610.1; -; Genomic_DNA.
DR RefSeq; NP_188123.1; NM_112367.3.
DR AlphaFoldDB; Q9LKA0; -.
DR SMR; Q9LKA0; -.
DR STRING; 3702.AT3G15050.1; -.
DR PaxDb; Q9LKA0; -.
DR PRIDE; Q9LKA0; -.
DR ProteomicsDB; 175148; -.
DR EnsemblPlants; AT3G15050.1; AT3G15050.1; AT3G15050.
DR GeneID; 820734; -.
DR Gramene; AT3G15050.1; AT3G15050.1; AT3G15050.
DR KEGG; ath:AT3G15050; -.
DR Araport; AT3G15050; -.
DR TAIR; locus:2086385; AT3G15050.
DR eggNOG; ENOG502QREU; Eukaryota.
DR HOGENOM; CLU_060053_1_0_1; -.
DR InParanoid; Q9LKA0; -.
DR OMA; DLGKESW; -.
DR OrthoDB; 1170329at2759; -.
DR PhylomeDB; Q9LKA0; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9LKA0; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR Pfam; PF00612; IQ; 1.
DR PROSITE; PS50096; IQ; 1.
PE 1: Evidence at protein level;
KW Calmodulin-binding; Cytoplasm; Cytoskeleton; Nucleus; Reference proteome.
FT CHAIN 1..259
FT /note="Protein IQ-DOMAIN 10"
FT /id="PRO_0000453117"
FT DOMAIN 50..77
FT /note="IQ"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT REGION 18..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 61..71
FT /note="Calmodulin-binding"
FT /evidence="ECO:0000303|PubMed:16368012"
FT REGION 226..259
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 231..247
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 259 AA; 29591 MW; 712ACC3CAC3476F0 CRC64;
MGSGWLLRSI ICLNGTKKNK SNRGNVHSET SNRVKPVESS SAASTKLTVE VAVIRIQKAF
RAFKARKRLC SLKSARRFNS LIQGHTVMNQ TSTALNVIHS WYDIQNQIRA RRLYMVTQGR
LQHKRLENRL KLEIKLHELE VEWCGGSETM EEILAKIQQK EEATVKRERA MAYAFSHQWR
ANATQYLGQA SFNLGKESWG WSWKERWIAA RPWEIRAQCY VVKPIKPSKK PEKSSPNNVI
TKTSAKPDEV GNSKKPGSG
