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IQD1_ARATH
ID   IQD1_ARATH              Reviewed;         454 AA.
AC   Q9SF32;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 111.
DE   RecName: Full=Protein IQ-DOMAIN 1 {ECO:0000303|PubMed:15960618};
DE            Short=AtIQD1 {ECO:0000303|PubMed:16368012};
GN   Name=IQD1 {ECO:0000303|PubMed:15960618};
GN   OrderedLocusNames=At3g09710 {ECO:0000312|Araport:AT3G09710};
GN   ORFNames=F11F8.30 {ECO:0000312|EMBL:AAF23301.1};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE
RP   SPECIFICITY, INDUCTION, INTERACTION WITH CALMODULIN, AND GENE FAMILY.
RC   STRAIN=cv. Columbia;
RX   PubMed=15960618; DOI=10.1111/j.1365-313x.2005.02435.x;
RA   Levy M., Wang Q., Kaspi R., Parrella M.P., Abel S.;
RT   "Arabidopsis IQD1, a novel calmodulin-binding nuclear protein, stimulates
RT   glucosinolate accumulation and plant defense.";
RL   Plant J. 43:79-96(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130713; DOI=10.1038/35048706;
RA   Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA   Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA   Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA   Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA   Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA   Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA   Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA   Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA   Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA   Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA   Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA   Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA   de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA   Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA   Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA   Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA   Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA   Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA   Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA   Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA   Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA   Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA   Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA   Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT   "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL   Nature 408:820-822(2000).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RA   Shinn P., Chen H., Cheuk R.F., Kim C.J., Ecker J.R.;
RT   "Arabidopsis ORF clones.";
RL   Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   INTERACTION WITH CALMODULIN, GENE FAMILY, AND NOMENCLATURE.
RC   STRAIN=cv. Columbia;
RX   PubMed=16368012; DOI=10.1186/1471-2148-5-72;
RA   Abel S., Savchenko T., Levy M.;
RT   "Genome-wide comparative analysis of the IQD gene families in Arabidopsis
RT   thaliana and Oryza sativa.";
RL   BMC Evol. Biol. 5:72-72(2005).
RN   [6]
RP   FUNCTION, INTERACTION WITH KLCR1; CAM1; CAM2; CML8 AND CML9, AND
RP   SUBCELLULAR LOCATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=23204523; DOI=10.1074/jbc.m112.396200;
RA   Buerstenbinder K., Savchenko T., Mueller J., Adamson A.W., Stamm G.,
RA   Kwong R., Zipp B.J., Dinesh D.C., Abel S.;
RT   "Arabidopsis calmodulin-binding protein IQ67-domain 1 localizes to
RT   microtubules and interacts with kinesin light chain-related protein-1.";
RL   J. Biol. Chem. 288:1871-1882(2013).
RN   [7]
RP   REVIEW.
RX   PubMed=23531692; DOI=10.4161/psb.24369;
RA   Abel S., Buerstenbinder K., Mueller J.;
RT   "The emerging function of IQD proteins as scaffolds in cellular signaling
RT   and trafficking.";
RL   Plant Signal. Behav. 8:E24369-E24369(2013).
RN   [8]
RP   SUBCELLULAR LOCATION, AND INTERACTION WITH CALMODULIN.
RC   STRAIN=cv. Columbia;
RX   PubMed=28115582; DOI=10.1104/pp.16.01743;
RA   Buerstenbinder K., Moeller B., Ploetner R., Stamm G., Hause G., Mitra D.,
RA   Abel S.;
RT   "The IQD family of calmodulin-binding proteins links calcium signaling to
RT   microtubules, membrane subdomains, and the nucleus.";
RL   Plant Physiol. 173:1692-1708(2017).
RN   [9]
RP   REVIEW.
RX   PubMed=28534650; DOI=10.1080/15592324.2017.1331198;
RA   Buerstenbinder K., Mitra D., Quegwer J.;
RT   "Functions of IQD proteins as hubs in cellular calcium and auxin signaling:
RT   A toolbox for shape formation and tissue-specification in plants?";
RL   Plant Signal. Behav. 12:E1331198-E1331198(2017).
CC   -!- FUNCTION: May be involved in cooperative interactions with calmodulins
CC       or calmodulin-like proteins. Modulates expression of glucosinolate
CC       pathway genes. May associate with nucleic acids and regulate gene
CC       expression at the transcriptional or post-transcriptional level
CC       (PubMed:15960618, PubMed:23204523). Recruits KLCR1 and calmodulin
CC       proteins to microtubules, thus being a potential scaffold in cellular
CC       signaling and trafficking (PubMed:23204523).
CC       {ECO:0000269|PubMed:15960618, ECO:0000269|PubMed:23204523}.
CC   -!- SUBUNIT: Binds to multiple calmodulin (CaM) in the presence of
CC       Ca(2+)(e.g. CaM1 and CaM2) and CaM-like (e.g. CML8 and CML9) proteins
CC       (PubMed:15960618, PubMed:23204523). Interacts with KLCR1
CC       (PubMed:23204523). {ECO:0000269|PubMed:15960618,
CC       ECO:0000269|PubMed:23204523}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00768,
CC       ECO:0000269|PubMed:15960618, ECO:0000269|PubMed:23204523,
CC       ECO:0000269|PubMed:28115582}. Nucleus, nucleolus
CC       {ECO:0000269|PubMed:28115582}. Cytoplasm, cytoskeleton
CC       {ECO:0000269|PubMed:23204523, ECO:0000269|PubMed:28115582}.
CC       Note=Recruits KLCR1 and calmodulin (CaM2) to microtubules, nucleus and
CC       nucleolus. {ECO:0000269|PubMed:23204523, ECO:0000269|PubMed:28115582}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=1;
CC         Comment=A number of isoforms are produced. According to EST
CC         sequences.;
CC       Name=1;
CC         IsoId=Q9SF32-1; Sequence=Displayed;
CC   -!- TISSUE SPECIFICITY: Expressed in roots, flowers, stems, siliques,
CC       inflorescence stems and whole shoots. Restricted to the vascular
CC       bundles. {ECO:0000269|PubMed:15960618}.
CC   -!- INDUCTION: By mechanical stimuli and aphid infestation, but not by
CC       jasmonate, salicylic acid, 1-aminocyclopropane-1-carboxylate (ACC) ou
CC       auxin (IAA). {ECO:0000269|PubMed:15960618}.
CC   -!- MISCELLANEOUS: IQD1 overexpression leads to increased resistance
CC       against herbivory by generalist chewing and phloem-feeding insects.
CC       {ECO:0000269|PubMed:15960618}.
CC   -!- SIMILARITY: Belongs to the IQD family. {ECO:0000305}.
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DR   EMBL; AY827468; AAX33644.1; -; mRNA.
DR   EMBL; AC016661; AAF23301.1; -; Genomic_DNA.
DR   EMBL; CP002686; AEE74801.1; -; Genomic_DNA.
DR   EMBL; BT020272; AAV84493.1; -; mRNA.
DR   EMBL; BT020448; AAW30026.1; -; mRNA.
DR   RefSeq; NP_187582.1; NM_111805.3. [Q9SF32-1]
DR   AlphaFoldDB; Q9SF32; -.
DR   SMR; Q9SF32; -.
DR   BioGRID; 5462; 2.
DR   IntAct; Q9SF32; 1.
DR   STRING; 3702.AT3G09710.2; -.
DR   iPTMnet; Q9SF32; -.
DR   PaxDb; Q9SF32; -.
DR   PRIDE; Q9SF32; -.
DR   ProteomicsDB; 228833; -. [Q9SF32-1]
DR   EnsemblPlants; AT3G09710.1; AT3G09710.1; AT3G09710. [Q9SF32-1]
DR   GeneID; 820128; -.
DR   Gramene; AT3G09710.1; AT3G09710.1; AT3G09710. [Q9SF32-1]
DR   KEGG; ath:AT3G09710; -.
DR   Araport; AT3G09710; -.
DR   eggNOG; ENOG502QUAG; Eukaryota.
DR   HOGENOM; CLU_024547_3_1_1; -.
DR   InParanoid; Q9SF32; -.
DR   PhylomeDB; Q9SF32; -.
DR   PRO; PR:Q9SF32; -.
DR   Proteomes; UP000006548; Chromosome 3.
DR   ExpressionAtlas; Q9SF32; baseline and differential.
DR   Genevisible; Q9SF32; AT.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005874; C:microtubule; IDA:UniProtKB.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR   GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR   GO; GO:0008017; F:microtubule binding; IDA:UniProtKB.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   Pfam; PF00612; IQ; 1.
DR   SMART; SM00015; IQ; 1.
DR   PROSITE; PS50096; IQ; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Calmodulin-binding; Cytoplasm; Cytoskeleton; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..454
FT                   /note="Protein IQ-DOMAIN 1"
FT                   /id="PRO_0000311120"
FT   DOMAIN          107..136
FT                   /note="IQ"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   REGION          103..113
FT                   /note="Calmodulin-binding"
FT                   /evidence="ECO:0000303|PubMed:16368012"
FT   REGION          272..454
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           421..428
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00768"
FT   COMPBIAS        274..332
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        339..363
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        365..413
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        438..454
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   454 AA;  50540 MW;  93376980F5367F34 CRC64;
     MVKKAKWLKN VKKAFSPDSK KLKHESVECQ DSVISYPVLI ATSRSSSPQF EVRVDEVNYE
     QKKNLYPPSS DSVTATVAHV LVDSPPSSPE SVHQAIVVNR FAGKSKEEAA AILIQSTFRG
     HLARRESQVM RGQERLKLLM EGSVVQRQAA ITLKCMQTLS RVQSQIRSRR IRMSEENQAR
     HKQLLQKHAK ELGGLKNGGN WNYSNQSKEQ VEAGMLHKYE ATMRRERALA YAFTHQQNLK
     SFSKTANPMF MDPSNPTWGW SWLERWMAGR PWESSEKEQN TTNNDNSSVK NSTNRNSQGG
     ETAKSSNRNK LNSSTKPNTP SASSTATRNP RKKRPIPSSI KSKSSDDEAK SSERNRRPSI
     ARPSVSDDET LSSSTARRSS NLIPTTKSAR GKPKSQTSSR VAVTTSTTEE SSILPEKAPA
     KKRLSTSASP APKPRRSSAP PKVEKGVLKA ERTP
 
 
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