IQD9_ARATH
ID IQD9_ARATH Reviewed; 263 AA.
AC Q0WNP8; O22952;
DT 02-JUN-2021, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2006, sequence version 1.
DT 25-MAY-2022, entry version 109.
DE RecName: Full=Protein IQ-DOMAIN 9 {ECO:0000303|PubMed:16368012};
DE Short=AtIQD9 {ECO:0000303|PubMed:16368012};
GN Name=IQD9 {ECO:0000303|PubMed:16368012};
GN OrderedLocusNames=At2g33990 {ECO:0000312|Araport:AT2G33990};
GN ORFNames=T14G11.11 {ECO:0000312|EMBL:AAB67617.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP INTERACTION WITH CALMODULIN, GENE FAMILY, AND NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=16368012; DOI=10.1186/1471-2148-5-72;
RA Abel S., Savchenko T., Levy M.;
RT "Genome-wide comparative analysis of the IQD gene families in Arabidopsis
RT thaliana and Oryza sativa.";
RL BMC Evol. Biol. 5:72-72(2005).
RN [5]
RP SUBCELLULAR LOCATION.
RC STRAIN=cv. Columbia;
RX PubMed=28115582; DOI=10.1104/pp.16.01743;
RA Buerstenbinder K., Moeller B., Ploetner R., Stamm G., Hause G., Mitra D.,
RA Abel S.;
RT "The IQD family of calmodulin-binding proteins links calcium signaling to
RT microtubules, membrane subdomains, and the nucleus.";
RL Plant Physiol. 173:1692-1708(2017).
RN [6]
RP REVIEW.
RX PubMed=28534650; DOI=10.1080/15592324.2017.1331198;
RA Buerstenbinder K., Mitra D., Quegwer J.;
RT "Functions of IQD proteins as hubs in cellular calcium and auxin signaling:
RT A toolbox for shape formation and tissue-specification in plants?";
RL Plant Signal. Behav. 12:E1331198-E1331198(2017).
CC -!- FUNCTION: May be involved in cooperative interactions with calmodulins
CC or calmodulin-like proteins (By similarity). Recruits calmodulin
CC proteins to microtubules, thus being a potential scaffold in cellular
CC signaling and trafficking (By similarity). May associate with nucleic
CC acids and regulate gene expression at the transcriptional or post-
CC transcriptional level (By similarity). {ECO:0000250|UniProtKB:Q9SF32}.
CC -!- SUBUNIT: Binds to multiple calmodulin (CaM) in the presence of Ca(2+)
CC and CaM-like proteins. {ECO:0000250|UniProtKB:Q9SF32}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00768}.
CC Nucleus, nuclear body {ECO:0000269|PubMed:28115582}.
CC -!- SIMILARITY: Belongs to the IQD family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB67617.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC002341; AAB67617.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002685; AEC08904.1; -; Genomic_DNA.
DR EMBL; AK229389; BAF01251.1; -; mRNA.
DR PIR; A84751; A84751.
DR RefSeq; NP_180946.2; NM_128950.5.
DR AlphaFoldDB; Q0WNP8; -.
DR SMR; Q0WNP8; -.
DR STRING; 3702.AT2G33990.1; -.
DR PaxDb; Q0WNP8; -.
DR PRIDE; Q0WNP8; -.
DR ProteomicsDB; 183280; -.
DR EnsemblPlants; AT2G33990.1; AT2G33990.1; AT2G33990.
DR GeneID; 817960; -.
DR Gramene; AT2G33990.1; AT2G33990.1; AT2G33990.
DR KEGG; ath:AT2G33990; -.
DR Araport; AT2G33990; -.
DR TAIR; locus:2055430; AT2G33990.
DR eggNOG; ENOG502QREU; Eukaryota.
DR HOGENOM; CLU_060053_1_0_1; -.
DR InParanoid; Q0WNP8; -.
DR OMA; NHRELEM; -.
DR OrthoDB; 1170329at2759; -.
DR PhylomeDB; Q0WNP8; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q0WNP8; baseline and differential.
DR GO; GO:0016604; C:nuclear body; IEA:UniProtKB-SubCell.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR PROSITE; PS50096; IQ; 1.
PE 1: Evidence at protein level;
KW Calmodulin-binding; Nucleus; Reference proteome.
FT CHAIN 1..263
FT /note="Protein IQ-DOMAIN 9"
FT /id="PRO_0000453116"
FT DOMAIN 46..75
FT /note="IQ"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT REGION 16..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 59..78
FT /note="Calmodulin-binding"
FT /evidence="ECO:0000303|PubMed:16368012"
FT REGION 216..263
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 21..28
FT /note="Nuclear localization signal 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00768"
FT MOTIF 107..114
FT /note="Nuclear localization signal 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00768"
FT COMPBIAS 218..241
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 263 AA; 30142 MW; C0EFBE11F04F561B CRC64;
MGSGNLIKAI IRLKKSKQGT EKKKTSAVKP KKGSKKKGTS LVTRSEDWAA TRIQTAFKAY
KARKSLRRLK GIARAKLSTE KQSVKNQAVV TLRYLHSWSK IQSEIKARRV CMVTEWRLKN
KRLEHQQKLE AKLHDVEVEW NGGSETKDEI LERILQREEA TIKRERALAY AFSHQWKADG
KTQWLGSYEL GNTNWGWSWK ERWISARPWE VRYSVTPKKP KSSKTDSNSP AKRTVSLSSV
PAKTPFPGAR NTVKPRRLSF PGA
