IQUB_HUMAN
ID IQUB_HUMAN Reviewed; 791 AA.
AC Q8NA54; A4D0X0; Q49AL6; Q4G189; Q5BJD9; Q6NUH6; Q8N9Y2;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 06-FEB-2007, sequence version 2.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=IQ and ubiquitin-like domain-containing protein;
GN Name=IQUB;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12690205; DOI=10.1126/science.1083423;
RA Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K.,
RA Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R.,
RA Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A.,
RA Kanematsu E., Gentles S., Christopoulos C.C., Choufani S., Kwasnicka D.,
RA Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S.,
RA Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R.,
RA Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N.,
RA Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E.,
RA Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R.,
RA Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T.,
RA Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W.,
RA Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A.,
RA Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X.,
RA Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E.,
RA Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H.,
RA Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J.,
RA Adams M.D., Tsui L.-C.;
RT "Human chromosome 7: DNA sequence and biology.";
RL Science 300:767-772(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANT
RP MET-126.
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP INTERACTION WITH ZMYND10.
RX PubMed=29601588; DOI=10.1371/journal.pgen.1007316;
RA Cho K.J., Noh S.H., Han S.M., Choi W.I., Kim H.Y., Yu S., Lee J.S.,
RA Rim J.H., Lee M.G., Hildebrandt F., Gee H.Y.;
RT "ZMYND10 stabilizes intermediate chain proteins in the cytoplasmic pre-
RT assembly of dynein arms.";
RL PLoS Genet. 14:E1007316-E1007316(2018).
RN [5]
RP STRUCTURE BY NMR OF 121-227.
RG RIKEN structural genomics initiative (RSGI);
RT "Solution structure of the novel identified ubiquitin-like domain in the
RT human hypothetical protein FLJ35834.";
RL Submitted (JUN-2006) to the PDB data bank.
RN [6]
RP VARIANT [LARGE SCALE ANALYSIS] HIS-735.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal cancers.";
RL Science 314:268-274(2006).
CC -!- FUNCTION: May play roles in cilia formation and/or maintenance.
CC {ECO:0000250}.
CC -!- SUBUNIT: Interacts with ZMYND10. {ECO:0000269|PubMed:29601588}.
CC -!- INTERACTION:
CC Q8NA54; Q9H161: ALX4; NbExp=3; IntAct=EBI-10220600, EBI-11317841;
CC Q8NA54; Q9NYG5-2: ANAPC11; NbExp=3; IntAct=EBI-10220600, EBI-12224467;
CC Q8NA54; Q86SG2: ANKRD23; NbExp=3; IntAct=EBI-10220600, EBI-5661893;
CC Q8NA54; Q6PI77: BHLHB9; NbExp=3; IntAct=EBI-10220600, EBI-11519926;
CC Q8NA54; Q9H2G9: BLZF1; NbExp=6; IntAct=EBI-10220600, EBI-2548012;
CC Q8NA54; Q13137: CALCOCO2; NbExp=3; IntAct=EBI-10220600, EBI-739580;
CC Q8NA54; Q8NHQ1: CEP70; NbExp=3; IntAct=EBI-10220600, EBI-739624;
CC Q8NA54; Q8TAP6: CEP76; NbExp=3; IntAct=EBI-10220600, EBI-742887;
CC Q8NA54; P28329-3: CHAT; NbExp=3; IntAct=EBI-10220600, EBI-25837549;
CC Q8NA54; Q96A83-2: COL26A1; NbExp=3; IntAct=EBI-10220600, EBI-21553822;
CC Q8NA54; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-10220600, EBI-3867333;
CC Q8NA54; Q14689-4: DIP2A; NbExp=3; IntAct=EBI-10220600, EBI-12019962;
CC Q8NA54; O75190-2: DNAJB6; NbExp=3; IntAct=EBI-10220600, EBI-12593112;
CC Q8NA54; O14645: DNALI1; NbExp=3; IntAct=EBI-10220600, EBI-395638;
CC Q8NA54; P50570-2: DNM2; NbExp=3; IntAct=EBI-10220600, EBI-10968534;
CC Q8NA54; P63167: DYNLL1; NbExp=3; IntAct=EBI-10220600, EBI-349105;
CC Q8NA54; O00167-2: EYA2; NbExp=3; IntAct=EBI-10220600, EBI-12807776;
CC Q8NA54; P22607: FGFR3; NbExp=3; IntAct=EBI-10220600, EBI-348399;
CC Q8NA54; Q8TB36: GDAP1; NbExp=3; IntAct=EBI-10220600, EBI-11110431;
CC Q8NA54; P14136: GFAP; NbExp=3; IntAct=EBI-10220600, EBI-744302;
CC Q8NA54; Q08379: GOLGA2; NbExp=3; IntAct=EBI-10220600, EBI-618309;
CC Q8NA54; P06396: GSN; NbExp=3; IntAct=EBI-10220600, EBI-351506;
CC Q8NA54; P01112: HRAS; NbExp=3; IntAct=EBI-10220600, EBI-350145;
CC Q8NA54; P04792: HSPB1; NbExp=3; IntAct=EBI-10220600, EBI-352682;
CC Q8NA54; Q8IYA8: IHO1; NbExp=4; IntAct=EBI-10220600, EBI-8638439;
CC Q8NA54; Q8WXH2: JPH3; NbExp=3; IntAct=EBI-10220600, EBI-1055254;
CC Q8NA54; Q9BW62: KATNAL1; NbExp=3; IntAct=EBI-10220600, EBI-743591;
CC Q8NA54; O60333-2: KIF1B; NbExp=3; IntAct=EBI-10220600, EBI-10975473;
CC Q8NA54; Q9BVG8-5: KIFC3; NbExp=3; IntAct=EBI-10220600, EBI-14069005;
CC Q8NA54; O14901: KLF11; NbExp=3; IntAct=EBI-10220600, EBI-948266;
CC Q8NA54; Q6A162: KRT40; NbExp=3; IntAct=EBI-10220600, EBI-10171697;
CC Q8NA54; O95678: KRT75; NbExp=3; IntAct=EBI-10220600, EBI-2949715;
CC Q8NA54; Q01546: KRT76; NbExp=3; IntAct=EBI-10220600, EBI-2952745;
CC Q8NA54; P60409: KRTAP10-7; NbExp=3; IntAct=EBI-10220600, EBI-10172290;
CC Q8NA54; P60411: KRTAP10-9; NbExp=3; IntAct=EBI-10220600, EBI-10172052;
CC Q8NA54; P59991: KRTAP12-2; NbExp=3; IntAct=EBI-10220600, EBI-10176379;
CC Q8NA54; P60329: KRTAP12-4; NbExp=6; IntAct=EBI-10220600, EBI-10176396;
CC Q8NA54; Q9UBR4-2: LHX3; NbExp=3; IntAct=EBI-10220600, EBI-12039345;
CC Q8NA54; P02545: LMNA; NbExp=3; IntAct=EBI-10220600, EBI-351935;
CC Q8NA54; P43360: MAGEA6; NbExp=3; IntAct=EBI-10220600, EBI-1045155;
CC Q8NA54; Q99750: MDFI; NbExp=3; IntAct=EBI-10220600, EBI-724076;
CC Q8NA54; Q9HBE1-4: PATZ1; NbExp=3; IntAct=EBI-10220600, EBI-11022007;
CC Q8NA54; Q8WWB5: PIH1D2; NbExp=3; IntAct=EBI-10220600, EBI-10232538;
CC Q8NA54; Q9Y446: PKP3; NbExp=3; IntAct=EBI-10220600, EBI-2880227;
CC Q8NA54; P78424: POU6F2; NbExp=3; IntAct=EBI-10220600, EBI-12029004;
CC Q8NA54; Q9NQX0: PRDM6; NbExp=3; IntAct=EBI-10220600, EBI-11320284;
CC Q8NA54; O60260-5: PRKN; NbExp=3; IntAct=EBI-10220600, EBI-21251460;
CC Q8NA54; E9PI22: PRR23D1; NbExp=3; IntAct=EBI-10220600, EBI-23335840;
CC Q8NA54; Q15669: RHOH; NbExp=3; IntAct=EBI-10220600, EBI-1244971;
CC Q8NA54; Q9Y3C5: RNF11; NbExp=3; IntAct=EBI-10220600, EBI-396669;
CC Q8NA54; Q8IYX7: SAXO1; NbExp=3; IntAct=EBI-10220600, EBI-3957636;
CC Q8NA54; Q16637: SMN2; NbExp=6; IntAct=EBI-10220600, EBI-395421;
CC Q8NA54; O60504: SORBS3; NbExp=3; IntAct=EBI-10220600, EBI-741237;
CC Q8NA54; Q7Z699: SPRED1; NbExp=6; IntAct=EBI-10220600, EBI-5235340;
CC Q8NA54; Q8N0S2: SYCE1; NbExp=3; IntAct=EBI-10220600, EBI-6872807;
CC Q8NA54; O14656-2: TOR1A; NbExp=3; IntAct=EBI-10220600, EBI-25847109;
CC Q8NA54; Q05BL1: TP53BP2; NbExp=3; IntAct=EBI-10220600, EBI-11952721;
CC Q8NA54; Q12933: TRAF2; NbExp=3; IntAct=EBI-10220600, EBI-355744;
CC Q8NA54; Q9Y4K3: TRAF6; NbExp=3; IntAct=EBI-10220600, EBI-359276;
CC Q8NA54; P36406: TRIM23; NbExp=7; IntAct=EBI-10220600, EBI-740098;
CC Q8NA54; P14373: TRIM27; NbExp=3; IntAct=EBI-10220600, EBI-719493;
CC Q8NA54; Q8IWZ5: TRIM42; NbExp=3; IntAct=EBI-10220600, EBI-5235829;
CC Q8NA54; Q86XT4: TRIM50; NbExp=3; IntAct=EBI-10220600, EBI-9867283;
CC Q8NA54; Q9BYV2: TRIM54; NbExp=4; IntAct=EBI-10220600, EBI-2130429;
CC Q8NA54; O76024: WFS1; NbExp=3; IntAct=EBI-10220600, EBI-720609;
CC Q8NA54; P52747: ZNF143; NbExp=3; IntAct=EBI-10220600, EBI-2849334;
CC Q8NA54; Q86VK4-3: ZNF410; NbExp=3; IntAct=EBI-10220600, EBI-11741890;
CC Q8NA54; Q8TF50: ZNF526; NbExp=3; IntAct=EBI-10220600, EBI-11035148;
CC Q8NA54; Q9UGI0: ZRANB1; NbExp=3; IntAct=EBI-10220600, EBI-527853;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8NA54-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8NA54-2; Sequence=VSP_022830, VSP_022831;
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DR EMBL; AK093153; BAC04074.1; -; mRNA.
DR EMBL; AK093393; BAC04153.1; -; mRNA.
DR EMBL; CH236947; EAL24336.1; -; Genomic_DNA.
DR EMBL; BC026173; AAH26173.1; -; mRNA.
DR EMBL; BC036121; AAH36121.1; -; mRNA.
DR EMBL; BC091520; AAH91520.1; -; mRNA.
DR EMBL; BC128181; AAI28182.1; -; mRNA.
DR CCDS; CCDS5787.1; -. [Q8NA54-1]
DR RefSeq; NP_001269784.1; NM_001282855.1. [Q8NA54-1]
DR RefSeq; NP_001308222.1; NM_001321293.1. [Q8NA54-1]
DR RefSeq; NP_849149.3; NM_178827.4. [Q8NA54-1]
DR RefSeq; XP_005250218.1; XM_005250161.3. [Q8NA54-1]
DR RefSeq; XP_011514135.1; XM_011515833.2. [Q8NA54-1]
DR RefSeq; XP_011514136.1; XM_011515834.2. [Q8NA54-1]
DR RefSeq; XP_016867260.1; XM_017011771.1. [Q8NA54-1]
DR PDB; 2DAF; NMR; -; A=123-227.
DR PDBsum; 2DAF; -.
DR AlphaFoldDB; Q8NA54; -.
DR SMR; Q8NA54; -.
DR BioGRID; 127562; 78.
DR IntAct; Q8NA54; 75.
DR STRING; 9606.ENSP00000417769; -.
DR iPTMnet; Q8NA54; -.
DR PhosphoSitePlus; Q8NA54; -.
DR BioMuta; IQUB; -.
DR DMDM; 125950212; -.
DR EPD; Q8NA54; -.
DR MassIVE; Q8NA54; -.
DR PaxDb; Q8NA54; -.
DR PeptideAtlas; Q8NA54; -.
DR PRIDE; Q8NA54; -.
DR ProteomicsDB; 72638; -. [Q8NA54-1]
DR ProteomicsDB; 72639; -. [Q8NA54-2]
DR Antibodypedia; 17626; 23 antibodies from 10 providers.
DR DNASU; 154865; -.
DR Ensembl; ENST00000324698.11; ENSP00000324882.6; ENSG00000164675.11. [Q8NA54-1]
DR Ensembl; ENST00000466202.5; ENSP00000417769.1; ENSG00000164675.11. [Q8NA54-1]
DR Ensembl; ENST00000484508.5; ENSP00000417285.1; ENSG00000164675.11. [Q8NA54-2]
DR GeneID; 154865; -.
DR KEGG; hsa:154865; -.
DR MANE-Select; ENST00000324698.11; ENSP00000324882.6; NM_178827.5; NP_849149.3.
DR UCSC; uc003vkn.4; human. [Q8NA54-1]
DR CTD; 154865; -.
DR DisGeNET; 154865; -.
DR GeneCards; IQUB; -.
DR HGNC; HGNC:21995; IQUB.
DR HPA; ENSG00000164675; Tissue enriched (testis).
DR neXtProt; NX_Q8NA54; -.
DR OpenTargets; ENSG00000164675; -.
DR PharmGKB; PA162392258; -.
DR VEuPathDB; HostDB:ENSG00000164675; -.
DR eggNOG; ENOG502QRQT; Eukaryota.
DR GeneTree; ENSGT00390000014326; -.
DR HOGENOM; CLU_014415_0_0_1; -.
DR InParanoid; Q8NA54; -.
DR OMA; TFAQKER; -.
DR PhylomeDB; Q8NA54; -.
DR TreeFam; TF323180; -.
DR PathwayCommons; Q8NA54; -.
DR SignaLink; Q8NA54; -.
DR BioGRID-ORCS; 154865; 11 hits in 1065 CRISPR screens.
DR ChiTaRS; IQUB; human.
DR EvolutionaryTrace; Q8NA54; -.
DR GenomeRNAi; 154865; -.
DR Pharos; Q8NA54; Tdark.
DR PRO; PR:Q8NA54; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q8NA54; protein.
DR Bgee; ENSG00000164675; Expressed in sperm and 99 other tissues.
DR ExpressionAtlas; Q8NA54; baseline and differential.
DR Genevisible; Q8NA54; HS.
DR GO; GO:0001669; C:acrosomal vesicle; IBA:GO_Central.
DR GO; GO:0031514; C:motile cilium; IBA:GO_Central.
DR GO; GO:0060271; P:cilium assembly; IBA:GO_Central.
DR GO; GO:0007224; P:smoothened signaling pathway; IEA:Ensembl.
DR InterPro; IPR037695; IQUB.
DR InterPro; IPR000626; Ubiquitin-like_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR21074; PTHR21074; 1.
DR Pfam; PF00240; ubiquitin; 1.
DR SUPFAM; SSF54236; SSF54236; 1.
DR PROSITE; PS50053; UBIQUITIN_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Cilium biogenesis/degradation;
KW Reference proteome.
FT CHAIN 1..791
FT /note="IQ and ubiquitin-like domain-containing protein"
FT /id="PRO_0000274601"
FT DOMAIN 131..207
FT /note="Ubiquitin-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00214"
FT DOMAIN 338..367
FT /note="IQ"
FT REGION 1..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..23
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 42..61
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 587..680
FT /note="VPQDPLKFYKKIYFCHSCQLYLPSTEFSVSSTSRRIYRCRNCINLQNEAQKR
FT ESFLKYKCLLQQLYYTEADYEDDSKIAFLMQLQDIQYLTENI -> MGGEYLSMAL
FT (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_022830"
FT VAR_SEQ 681..791
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_022831"
FT VARIANT 126
FT /note="V -> M (in dbSNP:rs10255061)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_030332"
FT VARIANT 691
FT /note="D -> N (in dbSNP:rs17146009)"
FT /id="VAR_030333"
FT VARIANT 735
FT /note="R -> H (in a colorectal cancer sample; somatic
FT mutation; dbSNP:rs1525626)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_036291"
FT VARIANT 735
FT /note="R -> P (in dbSNP:rs1525626)"
FT /id="VAR_030334"
FT CONFLICT 4
FT /note="Q -> R (in Ref. 1; BAC04074)"
FT /evidence="ECO:0000305"
FT CONFLICT 252
FT /note="F -> S (in Ref. 1; BAC04074)"
FT /evidence="ECO:0000305"
FT CONFLICT 343
FT /note="I -> T (in Ref. 1; BAC04074)"
FT /evidence="ECO:0000305"
FT STRAND 131..137
FT /evidence="ECO:0007829|PDB:2DAF"
FT TURN 138..140
FT /evidence="ECO:0007829|PDB:2DAF"
FT STRAND 143..148
FT /evidence="ECO:0007829|PDB:2DAF"
FT STRAND 150..152
FT /evidence="ECO:0007829|PDB:2DAF"
FT HELIX 154..165
FT /evidence="ECO:0007829|PDB:2DAF"
FT TURN 169..171
FT /evidence="ECO:0007829|PDB:2DAF"
FT STRAND 172..176
FT /evidence="ECO:0007829|PDB:2DAF"
FT STRAND 179..181
FT /evidence="ECO:0007829|PDB:2DAF"
FT HELIX 187..190
FT /evidence="ECO:0007829|PDB:2DAF"
FT STRAND 197..205
FT /evidence="ECO:0007829|PDB:2DAF"
FT TURN 207..209
FT /evidence="ECO:0007829|PDB:2DAF"
SQ SEQUENCE 791 AA; 92581 MW; 3D16F8BF4BAED522 CRC64;
MSNQQEKYEA QNIVNSTEES DDAFDTVTIP VPSEEPQESD QTEEHESGIE QFSESHAIHV
EEQSDQSFSS LEPDNEQLME EVISPRQVSY TPQHHEKQYA MQRPNDDSLA FLDKIKSVKE
SLQESVEDSL ATVKVVLIPV GQEIVIPFKV DTILKYLKDH FSHLLGIPHS VLQIRYSGKI
LKNNETLVQH GVKPQEIVQV EIFSTNPDLY PVRRIDGLTD VSQIITVTVQ TGLDQYQQVP
VEIVKSDFHK PFLGGFRHKV TGVEYHNAGT QTVPKRIPER LSIFCRDTQT VFQKKNLQQT
TNTTSTQMTN IGVYVSNMTD KLVTPGKYFS AAEYHAQRLK AVIVIQTYYR QWHAKIFVEN
LRRQKSLRLE WETQQELRKI REKEEWIKLD YHRRHNPKTN EDFEFLYNAL EFWRQEELTR
INQSFTGAER KAALCELLEK ETQIIASIGR HRYIAYMANQ EAAIQAFLDK CSAPKIWRTP
NGKTIEMDTQ FTIRARELQN IYKCIMLKNI SQDERLDVLL TLKHTVKEHE CKLTQEILEL
IDREVDLMMR GVKHHNLEGL RKRIATLFFH YIKTPLFNPE VAKYLKVPQD PLKFYKKIYF
CHSCQLYLPS TEFSVSSTSR RIYRCRNCIN LQNEAQKRES FLKYKCLLQQ LYYTEADYED
DSKIAFLMQL QDIQYLTENI WASQSVLSAC DNLSDLVMVR WNKSLEWSPW NCILLTKDEA
AAHLKLTSIE EGYERSFIHK IKHKHILAKN YFSQVPVLAS FILDDGEIDE IRWKYHSDTT
PKIIESQRPP H
