ID   IQUB_MACFA              Reviewed;         790 AA.
AC   Q4R6T7; Q4R6Q1;
DT   06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 2.
DT   03-AUG-2022, entry version 59.
DE   RecName: Full=IQ and ubiquitin-like domain-containing protein;
GN   Name=IQUB; ORFNames=QtsA-17155, QtsA-17428;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play roles in cilia formation and/or maintenance.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with ZMYND10. {ECO:0000250|UniProtKB:Q8NA54}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAE01223.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AB169129; BAE01223.1; ALT_INIT; mRNA.
DR   EMBL; AB169093; BAE01187.1; -; mRNA.
DR   RefSeq; NP_001270025.1; NM_001283096.1.
DR   AlphaFoldDB; Q4R6T7; -.
DR   SMR; Q4R6T7; -.
DR   STRING; 9541.XP_005550694.1; -.
DR   PRIDE; Q4R6T7; -.
DR   GeneID; 101926148; -.
DR   CTD; 154865; -.
DR   eggNOG; ENOG502QRQT; Eukaryota.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0030030; P:cell projection organization; IEA:UniProtKB-KW.
DR   InterPro; IPR037695; IQUB.
DR   InterPro; IPR000626; Ubiquitin-like_dom.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR21074; PTHR21074; 1.
DR   Pfam; PF00240; ubiquitin; 1.
DR   SUPFAM; SSF54236; SSF54236; 1.
DR   PROSITE; PS50053; UBIQUITIN_2; 1.
PE   2: Evidence at transcript level;
KW   Cilium biogenesis/degradation; Reference proteome.
FT   CHAIN           1..790
FT                   /note="IQ and ubiquitin-like domain-containing protein"
FT                   /id="PRO_0000274602"
FT   DOMAIN          130..206
FT                   /note="Ubiquitin-like"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00214"
FT   DOMAIN          337..366
FT                   /note="IQ"
FT   REGION          1..49
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..22
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        327
FT                   /note="Y -> C (in Ref. 1; BAE01187)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        402
FT                   /note="F -> S (in Ref. 1; BAE01187)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   790 AA;  92399 MW;  6F1493D7C50B935C CRC64;
     MSNQPKKYET QNIANSTEES DAFDIVTIPV PSEEPQESDQ TEEHESGIEQ FSESHAIHVE
     EQSDRSFSSL EPDSEQLMKE VISPRQVSYT PQHHEKQYAM QSPNDDSLAF LDKIKAIKES
     LQESMEDSLA TVKVVLIPVG QEIVISFKVD TVLKYLKDYF SHLLGIPLSV LQIRYSGKIL
     RNNETLVQHG VKPQEIIQVE IFSTNPDLYP VKRIDGLTDV SQIITVTVQT GLDRYQQVAV
     EIVKSDFHKP FLGGFRHKVT GVEYHHAGTQ TVPKKIPERL SVFCRDTQTV FQKKNLQQTT
     NTTSTQMTNI GVYVSNMTDK LVTPGKYFSA AEYHAQRLKA VIVIQTYYRQ WHAKIFVEDL
     RRQKSLRLEW ETQQELRKIR EKEEWVKLDY HRRHNPKTSE DFEFLYNALE FWRQEELKRI
     NQSFTGAERK AALCELLEKE TQIIASIGRH RYIAYTANQE AAIQAFLDKC SAPKIWRTPN
     GKTIEMDTQF TIRARELQNI YKCIMLKNIS QDERLDVLLT LKHTVKEHEC KLTQEILELI
     DREVDLMMRG VKHHNLEGLR KRIATLFFHY IKTPLFNPEV AKYLKVPQDP LKFYKKIYFC
     HSCQLYLPST EFSISSTSRR IYRCRNCISL ENEAQKRESF LKYRCLLQQL YFTEADYEDD
     SKIAFLMQLQ DIQYLTENIW ASQSVLSAWD DLSDLVMVRW NKSLEWSPWN CILLTKDEAA
     AHLNLTSIEE GYERSFIHKI KHKHILAKNY FSQIPVLASF ILDDPEIDEI RWKHHSDTTP
     KIIESQRPPP