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IQUB_MOUSE
ID   IQUB_MOUSE              Reviewed;         788 AA.
AC   Q8CDK3; B2RQH8; Q3TT98;
DT   06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 2.
DT   03-AUG-2022, entry version 119.
DE   RecName: Full=IQ and ubiquitin-like domain-containing protein;
GN   Name=Iqub;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Testis;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
RN   [4]
RP   DISRUPTION PHENOTYPE, AND FUNCTION.
RX   PubMed=21289087; DOI=10.1091/mbc.e10-07-0596;
RA   Lai C.K., Gupta N., Wen X., Rangell L., Chih B., Peterson A.S., Bazan J.F.,
RA   Li L., Scales S.J.;
RT   "Functional characterization of putative cilia genes by high-content
RT   analysis.";
RL   Mol. Biol. Cell 22:1104-1119(2011).
CC   -!- FUNCTION: May play roles in cilia formation and/or maintenance.
CC       {ECO:0000269|PubMed:21289087}.
CC   -!- SUBUNIT: Interacts with ZMYND10. {ECO:0000250|UniProtKB:Q8NA54}.
CC   -!- DISRUPTION PHENOTYPE: Elongated cilia. {ECO:0000269|PubMed:21289087}.
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DR   EMBL; AK029931; BAC26685.1; -; mRNA.
DR   EMBL; AK161501; BAE36427.1; -; mRNA.
DR   EMBL; BC137937; AAI37938.1; -; mRNA.
DR   EMBL; BC137957; AAI37958.1; -; mRNA.
DR   CCDS; CCDS19941.1; -.
DR   RefSeq; NP_766123.2; NM_172535.3.
DR   AlphaFoldDB; Q8CDK3; -.
DR   SMR; Q8CDK3; -.
DR   BioGRID; 229558; 3.
DR   STRING; 10090.ENSMUSP00000051177; -.
DR   iPTMnet; Q8CDK3; -.
DR   PhosphoSitePlus; Q8CDK3; -.
DR   MaxQB; Q8CDK3; -.
DR   PaxDb; Q8CDK3; -.
DR   PRIDE; Q8CDK3; -.
DR   ProteomicsDB; 269094; -.
DR   Antibodypedia; 17626; 23 antibodies from 10 providers.
DR   Ensembl; ENSMUST00000052277; ENSMUSP00000051177; ENSMUSG00000046192.
DR   GeneID; 214704; -.
DR   KEGG; mmu:214704; -.
DR   UCSC; uc009bbr.2; mouse.
DR   CTD; 154865; -.
DR   MGI; MGI:3041159; Iqub.
DR   VEuPathDB; HostDB:ENSMUSG00000046192; -.
DR   eggNOG; ENOG502QRQT; Eukaryota.
DR   GeneTree; ENSGT00390000014326; -.
DR   HOGENOM; CLU_014415_0_0_1; -.
DR   InParanoid; Q8CDK3; -.
DR   OMA; TFAQKER; -.
DR   OrthoDB; 508546at2759; -.
DR   PhylomeDB; Q8CDK3; -.
DR   TreeFam; TF323180; -.
DR   BioGRID-ORCS; 214704; 0 hits in 72 CRISPR screens.
DR   ChiTaRS; Iqub; mouse.
DR   PRO; PR:Q8CDK3; -.
DR   Proteomes; UP000000589; Chromosome 6.
DR   RNAct; Q8CDK3; protein.
DR   Bgee; ENSMUSG00000046192; Expressed in spermatid and 53 other tissues.
DR   Genevisible; Q8CDK3; MM.
DR   GO; GO:0001669; C:acrosomal vesicle; IDA:MGI.
DR   GO; GO:0031514; C:motile cilium; IDA:MGI.
DR   GO; GO:0060271; P:cilium assembly; IMP:MGI.
DR   GO; GO:0007224; P:smoothened signaling pathway; IMP:MGI.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR037695; IQUB.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR21074; PTHR21074; 1.
DR   SUPFAM; SSF54236; SSF54236; 1.
DR   PROSITE; PS50096; IQ; 1.
PE   1: Evidence at protein level;
KW   Cilium biogenesis/degradation; Reference proteome.
FT   CHAIN           1..788
FT                   /note="IQ and ubiquitin-like domain-containing protein"
FT                   /id="PRO_0000274603"
FT   DOMAIN          127..203
FT                   /note="Ubiquitin-like"
FT   DOMAIN          334..363
FT                   /note="IQ"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   REGION          1..89
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..15
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        35..50
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        51..77
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        521
FT                   /note="T -> A (in Ref. 1; BAC26685)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        535
FT                   /note="E -> Q (in Ref. 1; BAC26685)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   788 AA;  92130 MW;  AF4C2D579B7E101D CRC64;
     MSDPEEERVA DSTAHYEEAG KVISIPRPSD EAEGSDVMPE QDDEVQELTT ESEENVERHS
     EFSLSTPKSD DSKPREEVTS LGSASGSQDQ DYRLLDYQKG EDDELLFLHK IKAIKETLQT
     SVRESIATVK IVLIPAGQEI IMPFRVDAPF RFLKEHFAHL LHIPHYVLQI THEGIIVGNN
     ESLIQYGIKP QEIVQVEVFS TLPDQYPVRR IEGLSEGSQI ITVTIQTSID RYEEVAVEII
     KSDFHKPFLG GFRHKITGLE YHNAGTQTVP RKIPEKDNLF CRDTQTVFQK KKLQQTTNTT
     STQMTKIGVY VSNMTDKLLK PGNYFSAAEY HARRLHAVIV IQTSYRRWHA KRYVESLRKQ
     KKLRLEWEEE QELLKIQEKE EWIRMDYYRR HNPKTTEDFE LLYNALELWR QEEVEQICHY
     SSEAERKAAL CELLEKETQM IASIGRHRSA ARMERQDAAI QAFLDKCSAP NVWRRGDGKT
     IEMDTQFTIR ARELQSIYKC ILLKDLSQDE RLDILLTLKH TVKEHECKLT QEILELIDRE
     VDLMMRGVKP HNLEGLRKRI TTLFIHYIKT PLFNPEVAKY LKVPQDPLKF YDTIYFCHSC
     QNYLPSVEFS VSPTSHRVYR CRHCINLENE TQRRESFLKY KCLLQRLYYS EADYGDNSQI
     AFLMQLQDIK YLTENIWASQ SALSAWDDLN DLVMVRWDKH VEWSPWNCIL LTKDESTAHL
     RLPSIEKGYG HHFVHKIKHK HILAKNYFSQ IPTLASLILN DDEVEDIRSK HSTKSPPKII
     ITRRIQPH
 
 
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