ID   IQUB_RAT                Reviewed;         790 AA.
AC   Q45GW3; Q4FZV4;
DT   06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 2.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=IQ and ubiquitin-like domain-containing protein;
DE   AltName: Full=Protein TRS4;
GN   Name=Iqub;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Sprague-Dawley; TISSUE=Testis;
RA   Li Y.-C., Song X.-X., Liu Y.-X.;
RT   "TRS4, an IQ calmodulin-binding motif-containing protein, expressed
RT   specifically in murine testis.";
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May play roles in cilia formation and/or maintenance.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with ZMYND10. {ECO:0000250|UniProtKB:Q8NA54}.
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DR   EMBL; DQ132434; AAZ43073.1; -; mRNA.
DR   EMBL; BC099086; AAH99086.1; -; mRNA.
DR   RefSeq; NP_001029302.1; NM_001034130.1.
DR   AlphaFoldDB; Q45GW3; -.
DR   SMR; Q45GW3; -.
DR   STRING; 10116.ENSRNOP00000063053; -.
DR   PhosphoSitePlus; Q45GW3; -.
DR   PaxDb; Q45GW3; -.
DR   PRIDE; Q45GW3; -.
DR   Ensembl; ENSRNOT00000064983; ENSRNOP00000063053; ENSRNOG00000021729.
DR   GeneID; 296936; -.
DR   KEGG; rno:296936; -.
DR   CTD; 154865; -.
DR   RGD; 4145674; Iqub.
DR   eggNOG; ENOG502QRQT; Eukaryota.
DR   GeneTree; ENSGT00390000014326; -.
DR   HOGENOM; CLU_014415_0_0_1; -.
DR   InParanoid; Q45GW3; -.
DR   OMA; TFAQKER; -.
DR   OrthoDB; 508546at2759; -.
DR   PhylomeDB; Q45GW3; -.
DR   PRO; PR:Q45GW3; -.
DR   Proteomes; UP000002494; Chromosome 4.
DR   Bgee; ENSRNOG00000021729; Expressed in testis and 15 other tissues.
DR   Genevisible; Q45GW3; RN.
DR   GO; GO:0001669; C:acrosomal vesicle; ISO:RGD.
DR   GO; GO:0031514; C:motile cilium; ISO:RGD.
DR   GO; GO:0060271; P:cilium assembly; ISO:RGD.
DR   GO; GO:0007224; P:smoothened signaling pathway; ISO:RGD.
DR   InterPro; IPR037695; IQUB.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR21074; PTHR21074; 1.
DR   SUPFAM; SSF54236; SSF54236; 1.
PE   2: Evidence at transcript level;
KW   Cilium biogenesis/degradation; Reference proteome.
FT   CHAIN           1..790
FT                   /note="IQ and ubiquitin-like domain-containing protein"
FT                   /id="PRO_0000274604"
FT   DOMAIN          129..205
FT                   /note="Ubiquitin-like"
FT   DOMAIN          336..365
FT                   /note="IQ"
FT   REGION          1..100
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        32..49
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        442
FT                   /note="I -> V (in Ref. 1; AAZ43073)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        447
FT                   /note="G -> R (in Ref. 1; AAZ43073)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        689
FT                   /note="D -> G (in Ref. 1; AAZ43073)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        776
FT                   /note="E -> G (in Ref. 1; AAZ43073)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   790 AA;  91823 MW;  D71B203996487332 CRC64;
     MSDTEENVLD SPASGEAAGE VISIPGPTDE AEESDISPEQ EYEIEGFTTE SEETVEHYSD
     LSVSTPKSYD SKPRDEVVSL GSATDSHEQE YRLGDLGGDQ RSEEDEMSFL YKIKAIKENL
     QSSVKECIAT VKIVLIPAGQ EIVMPFRVDA PFRFLKEHFA HLLRIPHHVL QMAYTGISVG
     NNESLIQYGV KPREIVQMNV FSSEPDQYPV RRIEGLSEGS KIITVTIQTG IERYEEVAVE
     IVKSDFHKPF LGGFRHKITG LEYHNAGTQT VPKKIPEKDN LFCRDTQTVF QKKKLQQTMN
     TTSTQMTKIG VYVSNMTDKL LTPGSYFSAA EYHARRLNAV IVIQTAYRRW HAKCYVDSLR
     LQKKMRLEWE KEEELKKIRE KEEWIRMDYY RRHNPKTTED FELLFNALEL WRQEEVTQVE
     QYSSEAERKA ALCELLEKET QIIASIGRHR YVAQLERQDV ATQAFLDKCS ASNTWRRPDG
     QTVEMDTQFT IRARELQSIY KCILLKNLSQ DERLDILLTL KHTVKEHECK LTQEILELID
     REVDLMMRGV KSHNLEGLRK RITTLFIHYI KTPLFNPEVA KHLKVPQDPL KFYDKIYFCH
     SCQMYLPSVE FSVSPTSHRV YRCRHCINLE NETQRRESFL KYKCLLQRLY FSEANYEDNS
     HIAYLMQLQD IKYLTENIWA SQSALSAWDD LNDLVMVRWN KHVEWSPWNC ILLTKDEGTA
     HLKLESIEKG YGRLFIHKIK HKHILAKNYF SQVPVLASLI LKDDEIEAIR SKYSTENPPK
     IIVPHGIVPN