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IR21A_ANOGA
ID   IR21A_ANOGA             Reviewed;         975 AA.
AC   A0A1S4GYH6;
DT   17-JUN-2020, integrated into UniProtKB/Swiss-Prot.
DT   12-APR-2017, sequence version 1.
DT   25-MAY-2022, entry version 21.
DE   RecName: Full=Ionotropic receptor 21a {ECO:0000303|PubMed:32029627};
DE   Flags: Precursor;
GN   Name=Ir21a {ECO:0000303|PubMed:32029627};
GN   ORFNames=AGAP008511 {ECO:0000312|EMBL:AAAB01008964};
OS   Anopheles gambiae (African malaria mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=7165 {ECO:0000312|EMBL:AAAB01008964};
RN   [1] {ECO:0000312|EMBL:AAAB01008964}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PEST {ECO:0000312|EMBL:AAAB01008964};
RX   PubMed=12364791; DOI=10.1126/science.1076181;
RA   Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA   Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA   Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA   Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA   Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA   Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA   Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA   Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA   Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA   Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA   Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA   Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA   McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA   O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA   Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA   Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA   Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA   Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA   Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA   Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA   Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA   Collins F.H., Hoffman S.L.;
RT   "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL   Science 298:129-149(2002).
RN   [2] {ECO:0000305}
RP   FUNCTION, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX   PubMed=32029627; DOI=10.1126/science.aay9847;
RA   Greppi C., Laursen W.J., Budelli G., Chang E.C., Daniels A.M.,
RA   van Giesen L., Smidler A.L., Catteruccia F., Garrity P.A.;
RT   "Mosquito heat seeking is driven by an ancestral cooling receptor.";
RL   Science 367:681-684(2020).
CC   -!- FUNCTION: Integral part of a neural sensory system in the antenna that
CC       provides the neural basis for the response to environmental changes in
CC       temperature (thermosensation) (PubMed:32029627). Specifically, required
CC       for thermosensing by the cooling cell (PubMed:32029627). Plays a role
CC       in heat seeking and heat-stimulated blood feeding behavior
CC       (PubMed:32029627). {ECO:0000269|PubMed:32029627}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium membrane
CC       {ECO:0000269|PubMed:32029627}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- TISSUE SPECIFICITY: In both female and male antenna, expressed
CC       specifically in 3 sensory neurons of flagellomere 13 segment (at
CC       protein level). {ECO:0000269|PubMed:32029627}.
CC   -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC       family. {ECO:0000305}.
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DR   EMBL; AAAB01008964; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A0A1S4GYH6; -.
DR   VEuPathDB; VectorBase:AGAP008511; -.
DR   OMA; PPYIFRI; -.
DR   OrthoDB; 460569at2759; -.
DR   Proteomes; UP000007062; Chromosome 3R.
DR   GO; GO:0060170; C:ciliary membrane; IDA:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004970; F:ionotropic glutamate receptor activity; IEA:InterPro.
DR   GO; GO:0050961; P:detection of temperature stimulus involved in sensory perception; IMP:UniProtKB.
DR   GO; GO:0040040; P:thermosensory behavior; IMP:UniProtKB.
DR   InterPro; IPR019594; Glu/Gly-bd.
DR   InterPro; IPR001320; Iontro_rcpt.
DR   Pfam; PF00060; Lig_chan; 1.
DR   SMART; SM00918; Lig_chan-Glu_bd; 1.
PE   1: Evidence at protein level;
KW   Behavior; Cell membrane; Cell projection; Glycoprotein; Ion channel;
KW   Ion transport; Ligand-gated ion channel; Membrane; Receptor;
KW   Reference proteome; Signal; Transmembrane; Transmembrane helix; Transport.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..975
FT                   /note="Ionotropic receptor 21a"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_5010273893"
FT   TRANSMEM        433..453
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        505..525
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        708..728
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          757..839
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          911..938
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        762..802
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        67
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   CARBOHYD        177
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   CARBOHYD        355
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   CARBOHYD        464
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   CARBOHYD        561
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   CARBOHYD        586
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   CARBOHYD        611
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   CARBOHYD        763
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   CARBOHYD        797
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ   SEQUENCE   975 AA;  109617 MW;  A35F2AB36394FC1C CRC64;
     MFKRIVLAVI NLVFLIVSTT AFASLHYPES FNQQLIRYKG RDSSNGYFEL ASEAYYTGTY
     DLVEELNETA TCLRADCREQ SNSSPVVRDR RRVDPTFYGH PKTREQIWER NFAHVIEDNR
     QTLSLVTLLN KIILKYLHSC IPIVLFDTYV ATTENYMLEA LFSDFPITYI TGRIGPNYTL
     DNPGILEPTG PQCRSYIIFL ADVMMTRKVI GPQMNSYVVL IPRSSQWKLQ EFLAAKQSRD
     IINLLVIGES YSVDKRINNE QPYVLYTHEL YIDGLGANRP QVLTSWIGNK FSRNNVNLFP
     RKLRKGFSGH RFTVKAAHQP PFMIKRLSTD GVGNVNIRWE GLEMRLLRVM AQYLNFTYDI
     IEPGRTELGP GDAVVEEIKR GQGDMGLAGI YVTIERNLAT EMSVSHSTDC AAFLTLMSSA
     LPRYRAILGP FQWPVWVAVI LIYLLAIFPL AFSDKMTLRH LLGNWSEIEN MFWYVFGTFT
     NSLTFQGENS WSNTRKTSTR MLIGIYWVFT IIITACYTGS IIAFITLPVE PERIDGIEQL
     SRGFFRVGTL DRGGWERWFL NSSHKQTNKL LKDLRFVSSV DEGIRNVTEA FLISYAFIGS
     KGELEFLIKS NLSHQFENKR YGLHVSRECF ALYGVSMVFP PNSVHRDPIN NAILYMQEAG
     LIGKLNRDVT WETMKTKDGR RKEASVGEVL RSTAPSERGL TLADTEGMFL LMLFGYVVAL
     GVLISEWVGG CTNKCREVLK ERAERLKAAA AEIAAAATAG SDNGSLPVSS PTSTNRNSPH
     KRTGPNGVEN SLPASGNGSA TVRRIRLTGE DSENEPNEYD VPPDAASDGG SSLQRHSLSE
     CLSEVSAHTM QDLYNGPDRR HSTIVFLDGQ LMSEEEAQRK VARSKSRHRH SLSSVLEREV
     SQLFRFLGKE SPHSARADES SDAGGLVRRG AGRERKEMKV AVEINARATE EGQQGPGAAV
     GRRSIEATFG EKLLH
 
 
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