ID   IR221_CANAL             Reviewed;         239 AA.
AC   Q59YF4; A0A1D8PIH7; Q59YQ3;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 62.
DE   RecName: Full=Increased recombination centers protein 22-1;
DE   Flags: Precursor;
GN   Name=IRC22-1; OrderedLocusNames=CAALFM_C209780CA;
GN   ORFNames=CaO19.1372, CaO19.8952;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- FUNCTION: Is probably involved in a pathway contributing to genomic
CC       integrity.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Single-pass type I membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IRC22 family. {ECO:0000305}.
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DR   EMBL; CP017624; AOW27956.1; -; Genomic_DNA.
DR   RefSeq; XP_714546.1; XM_709453.2.
DR   AlphaFoldDB; Q59YF4; -.
DR   STRING; 237561.Q59YF4; -.
DR   PRIDE; Q59YF4; -.
DR   GeneID; 3643805; -.
DR   KEGG; cal:CAALFM_C209780CA; -.
DR   CGD; CAL0000174666; orf19.8952.
DR   VEuPathDB; FungiDB:C2_09780C_A; -.
DR   HOGENOM; CLU_078554_0_0_1; -.
DR   InParanoid; Q59YF4; -.
DR   OMA; YQEEWIP; -.
DR   OrthoDB; 1349929at2759; -.
DR   PRO; PR:Q59YF4; -.
DR   Proteomes; UP000000559; Chromosome 2.
DR   GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; Membrane; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..239
FT                   /note="Increased recombination centers protein 22-1"
FT                   /id="PRO_0000399070"
FT   TOPO_DOM        20..161
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        162..182
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        183..239
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          201..239
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        206..225
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   239 AA;  25962 MW;  5A2C56D2915409FE CRC64;
     MKLSTIFTAF AATIATVAGY ETTGSKQTVD ILIDYIIKET PELSQNDVAN WENGDTVTLQ
     YVVNNNEESE ITVVGVTGQF KNPVNNEIVT NLTTGKVGPI AVPPGEAIKF DQKINVDLIP
     ANYELIPYVF IAQDSLIKVI PCRGQLATIV DAAVSFFDPR LIFLELVLLI TFAGLIYVGY
     EIWGKQYFKG VAPVKAKKVS AAKASSPVAS GPSTTSATGY DTNWIPESHL KQKKTKKVN