ID   IR221_CANTT             Reviewed;         234 AA.
AC   C5M580;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 27.
DE   RecName: Full=Increased recombination centers protein 22-1;
DE   Flags: Precursor;
GN   Name=IRC22-1; ORFNames=CTRG_02058;
OS   Candida tropicalis (strain ATCC MYA-3404 / T1) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=294747;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-3404 / T1;
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA   Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA   Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA   Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA   Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA   Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA   Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA   Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA   Birren B.W., Kellis M., Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
CC   -!- FUNCTION: Is probably involved in a pathway contributing to genomic
CC       integrity.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Single-pass type I membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IRC22 family. {ECO:0000305}.
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DR   EMBL; GG692396; EER35196.1; -; Genomic_DNA.
DR   RefSeq; XP_002547751.1; XM_002547705.1.
DR   AlphaFoldDB; C5M580; -.
DR   STRING; 5482.XP_002547751.1; -.
DR   EnsemblFungi; EER35196; EER35196; CTRG_02058.
DR   GeneID; 8297155; -.
DR   KEGG; ctp:CTRG_02058; -.
DR   VEuPathDB; FungiDB:CTRG_02058; -.
DR   eggNOG; ENOG502S7BF; Eukaryota.
DR   HOGENOM; CLU_078554_0_0_1; -.
DR   OrthoDB; 1349929at2759; -.
DR   Proteomes; UP000002037; Unassembled WGS sequence.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; Membrane; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..234
FT                   /note="Increased recombination centers protein 22-1"
FT                   /id="PRO_0000399076"
FT   TOPO_DOM        20..161
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        162..182
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        183..234
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   234 AA;  25521 MW;  3E877601ED5BBD82 CRC64;
     MKFSTILTAL TAVIATVAGY ETSGKPHTVD ILIDYSIKET PELSQNDVAN WVNGDKYTLE
     YVVSNNEETE IAVVGVTGQF KNPVTNQIVT NLTTGQVGPI TVAPGESIKF EQIVDVDLMA
     NNYELFPYVF VAHDDLIKVI PCRGQLTSVV DATISFFDPR LILLELVLLV TFGAAAYFIY
     EIWGKQYLKG TAPVKVPARK SGSTVSKKGA SATASGFDES WIPEAHLKKN KKKA