IR222_CANAL
ID IR222_CANAL Reviewed; 239 AA.
AC Q59XW9; A0A1D8PIM9; Q59XS6;
DT 05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2017, sequence version 2.
DT 03-AUG-2022, entry version 66.
DE RecName: Full=Increased recombination centers protein 22-2;
DE Flags: Precursor;
GN Name=IRC22-2; OrderedLocusNames=CAALFM_C210010CA;
GN ORFNames=CaO19.1782, CaO19.9348;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC -!- FUNCTION: Is probably involved in a pathway contributing to genomic
CC integrity.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC Single-pass type I membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the IRC22 family. {ECO:0000305}.
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DR EMBL; CP017624; AOW27979.1; -; Genomic_DNA.
DR RefSeq; XP_714427.2; XM_709334.2.
DR AlphaFoldDB; Q59XW9; -.
DR STRING; 237561.Q59XW9; -.
DR GeneID; 3643962; -.
DR KEGG; cal:CAALFM_C210010CA; -.
DR CGD; CAL0000187589; orf19.9348.
DR VEuPathDB; FungiDB:C2_10010C_A; -.
DR eggNOG; ENOG502S7BF; Eukaryota.
DR HOGENOM; CLU_078554_0_0_1; -.
DR InParanoid; Q59XW9; -.
DR OrthoDB; 1349929at2759; -.
DR PRO; PR:Q59XW9; -.
DR Proteomes; UP000000559; Chromosome 2.
DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:CGD.
PE 3: Inferred from homology;
KW Endoplasmic reticulum; Membrane; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..239
FT /note="Increased recombination centers protein 22-2"
FT /id="PRO_0000399071"
FT TOPO_DOM 20..161
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 162..182
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 183..239
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 202..223
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 206..223
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 239 AA; 25964 MW; 2CF93589FE5FC302 CRC64;
MKLSTIFTAF AATIATVAGY ETTGSKQTVD ILIDYIIKET PELSQNDVAN WENGDTVTLQ
YVVNNNEESE ITVVGVTGQF KNPINNEIVT NLTTGKVGPI AVPPGEAIKF DQKINVDLIP
ANYELIPHVF IAQDSLIKVI PCRGQLATIV DAAVSFFDPR LIFLELVLLI TFAGLIYVGY
EIWGKQYFKG VAPVKAKKVS AAKASSPVAT GPSTTSATGY DTNWIPESHL KQKKTKKVN