ID   IR222_CANAW             Reviewed;         239 AA.
AC   P0CH79; C4YKR5; Q59XS6;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   05-OCT-2010, sequence version 1.
DT   25-MAY-2022, entry version 30.
DE   RecName: Full=Increased recombination centers protein 22-2;
DE   Flags: Precursor;
GN   Name=IRC22-2; ORFNames=CAWG_06072;
OS   Candida albicans (strain WO-1) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=294748;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WO-1;
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA   Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA   Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA   Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA   Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA   Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA   Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA   Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA   Birren B.W., Kellis M., Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
CC   -!- FUNCTION: Is probably involved in a pathway contributing to genomic
CC       integrity.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Single-pass type I membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IRC22 family. {ECO:0000305}.
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DR   EMBL; CH672354; EEQ47494.1; -; Genomic_DNA.
DR   AlphaFoldDB; P0CH79; -.
DR   STRING; 5476.P0CH79; -.
DR   EnsemblFungi; EEQ47494; EEQ47494; CAWG_06072.
DR   VEuPathDB; FungiDB:CAWG_06072; -.
DR   HOGENOM; CLU_078554_0_0_1; -.
DR   OMA; EDKSEWL; -.
DR   Proteomes; UP000001429; Chromosome 2, Supercontig 1.9.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; Membrane; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..239
FT                   /note="Increased recombination centers protein 22-2"
FT                   /id="PRO_0000399073"
FT   TOPO_DOM        20..161
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        162..182
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        183..239
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          201..239
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        206..225
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   239 AA;  25950 MW;  2CF93589FE58B375 CRC64;
     MKLSTIFTAF AATIATVAGY ETTGSKQTVD ILIDYIIKET PELSQNDVAN WENGDTVTLQ
     YVVNNNEESE ITVVGVTGQF KNPINNEIVT NLTTGKVGPI AVPPGEAIKF DQKINVDLIP
     ANYELIPHVF IAQDSLIKVI PCRGQLATIV DAAVSFFDPR LIFLELVLLI TFAGLIYVGY
     EIWGKQYFKG VAPVKAKKVS AAKASSPVAS GPSTTSATGY DTNWIPESHL KQKKTKKVN