ID   IR222_CANTT             Reviewed;         236 AA.
AC   C5M501;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 27.
DE   RecName: Full=Increased recombination centers protein 22-2;
DE   Flags: Precursor;
GN   Name=IRC22-2; ORFNames=CTRG_01979;
OS   Candida tropicalis (strain ATCC MYA-3404 / T1) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=294747;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-3404 / T1;
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA   Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA   Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA   Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA   Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA   Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA   Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA   Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA   Birren B.W., Kellis M., Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
CC   -!- FUNCTION: Is probably involved in a pathway contributing to genomic
CC       integrity.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Single-pass type I membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IRC22 family. {ECO:0000305}.
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DR   EMBL; GG692396; EER35117.1; -; Genomic_DNA.
DR   RefSeq; XP_002547672.1; XM_002547626.1.
DR   AlphaFoldDB; C5M501; -.
DR   STRING; 5482.XP_002547672.1; -.
DR   EnsemblFungi; EER35117; EER35117; CTRG_01979.
DR   GeneID; 8296334; -.
DR   KEGG; ctp:CTRG_01979; -.
DR   VEuPathDB; FungiDB:CTRG_01979; -.
DR   eggNOG; ENOG502S7BF; Eukaryota.
DR   HOGENOM; CLU_078554_0_0_1; -.
DR   OrthoDB; 1349929at2759; -.
DR   Proteomes; UP000002037; Unassembled WGS sequence.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; Membrane; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..236
FT                   /note="Increased recombination centers protein 22-2"
FT                   /id="PRO_0000399077"
FT   TOPO_DOM        20..161
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        162..182
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        183..236
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   236 AA;  25618 MW;  45EBCF69CAB70B6A CRC64;
     MKFSAILTAL TATIATVAGY ETSGKPHTVD ILIDYSIKET PEISQTDVAN WVNGQKYTLE
     YVVNNNEETE IAVVGVTGQF KNPVTNQIVT NLTTGQVGPI AVAPGESIKF EQIVDVDLIP
     DNYELIPHVF VAHDDLIKVI PCRGQLASIV DAAVSFFDPR LIFLELVLLA TFGGIAYFVY
     EIWGKQYLRG TAPVKVPVKK SGSPVAVKEA SPVGSASGFD ESWIPEAHLK KNKKKA