ID   IR3IP_BOVIN             Reviewed;          82 AA.
AC   Q1JQC2;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   13-JUN-2006, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Immediate early response 3-interacting protein 1 {ECO:0000305};
GN   Name=IER3IP1 {ECO:0000250|UniProtKB:Q9Y5U9};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford {ECO:0000312|EMBL:AAI16065.1};
RC   TISSUE=Ascending colon {ECO:0000312|EMBL:AAI16065.1};
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulator of endoplasmic reticulum secretion that acts as a
CC       key determinant of brain size. Required for secretion of extracellular
CC       matrix proteins. Required for correct brain development by depositing
CC       sufficient extracellular matrix proteins for tissue integrity and the
CC       proliferation of neural progenitors (By similarity). Acts as a
CC       regulator of the unfolded protein response (UPR) (By similarity).
CC       {ECO:0000250|UniProtKB:Q9CR20, ECO:0000250|UniProtKB:Q9Y5U9}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:Q9Y5U9}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the YOS1 family. {ECO:0000305}.
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DR   EMBL; BC116064; AAI16065.1; -; mRNA.
DR   RefSeq; NP_001106791.1; NM_001113320.1.
DR   RefSeq; XP_010808575.1; XM_010810273.2.
DR   RefSeq; XP_010815266.1; XM_010816964.2.
DR   AlphaFoldDB; Q1JQC2; -.
DR   SMR; Q1JQC2; -.
DR   STRING; 9913.ENSBTAP00000044053; -.
DR   PaxDb; Q1JQC2; -.
DR   PRIDE; Q1JQC2; -.
DR   Ensembl; ENSBTAT00000046794; ENSBTAP00000044053; ENSBTAG00000032961.
DR   GeneID; 101906131; -.
DR   GeneID; 768079; -.
DR   KEGG; bta:101906131; -.
DR   KEGG; bta:768079; -.
DR   CTD; 51124; -.
DR   VEuPathDB; HostDB:ENSBTAG00000032961; -.
DR   eggNOG; KOG4779; Eukaryota.
DR   GeneTree; ENSGT00510000047648; -.
DR   HOGENOM; CLU_152125_3_0_1; -.
DR   InParanoid; Q1JQC2; -.
DR   OMA; WASWQNV; -.
DR   OrthoDB; 1624874at2759; -.
DR   TreeFam; TF300263; -.
DR   Proteomes; UP000009136; Chromosome 24.
DR   Bgee; ENSBTAG00000032961; Expressed in granulosa cell and 107 other tissues.
DR   GO; GO:0030134; C:COPII-coated ER to Golgi transport vesicle; IBA:GO_Central.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.
DR   GO; GO:0030173; C:integral component of Golgi membrane; IBA:GO_Central.
DR   GO; GO:0007420; P:brain development; ISS:UniProtKB.
DR   GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IBA:GO_Central.
DR   GO; GO:0035265; P:organ growth; ISS:UniProtKB.
DR   GO; GO:0003331; P:positive regulation of extracellular matrix constituent secretion; ISS:UniProtKB.
DR   GO; GO:0050714; P:positive regulation of protein secretion; ISS:UniProtKB.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:2000269; P:regulation of fibroblast apoptotic process; ISS:UniProtKB.
DR   InterPro; IPR013880; Yos1.
DR   PANTHER; PTHR15858; PTHR15858; 1.
DR   Pfam; PF08571; Yos1; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; Membrane; Protein transport; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..82
FT                   /note="Immediate early response 3-interacting protein 1"
FT                   /id="PRO_0000257960"
FT   TRANSMEM        2..22
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        62..82
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   82 AA;  8969 MW;  2015B211F0AFF580 CRC64;
     MAFTLYSLLQ AALLCVNAIA VLHEERFLKN IGWGTDQGIG GFGEEPGIKS QLMNLIRSVR
     TVMRVPLIIV NSIAIVLLLL FG