ID   IR3IP_DANRE             Reviewed;          82 AA.
AC   Q4VBI2;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Immediate early response 3-interacting protein 1 {ECO:0000305};
GN   Name=ier3ip1 {ECO:0000250|UniProtKB:Q9Y5U9};
GN   ORFNames=zgc:112367 {ECO:0000303|Ref.1};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain {ECO:0000312|EMBL:AAH95786.1};
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulator of endoplasmic reticulum secretion that acts as a
CC       key determinant of brain size. Required for secretion of extracellular
CC       matrix proteins. Required for correct brain development by depositing
CC       sufficient extracellular matrix proteins for tissue integrity and the
CC       proliferation of neural progenitors (By similarity). Acts as a
CC       regulator of the unfolded protein response (UPR) (By similarity).
CC       {ECO:0000250|UniProtKB:Q9CR20, ECO:0000250|UniProtKB:Q9Y5U9}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:Q9Y5U9}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the YOS1 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC095786; AAH95786.1; -; mRNA.
DR   RefSeq; NP_001239302.1; NM_001252373.3.
DR   AlphaFoldDB; Q4VBI2; -.
DR   SMR; Q4VBI2; -.
DR   STRING; 7955.ENSDARP00000057864; -.
DR   PaxDb; Q4VBI2; -.
DR   Ensembl; ENSDART00000057865; ENSDARP00000057864; ENSDARG00000039601.
DR   GeneID; 554110; -.
DR   KEGG; dre:554110; -.
DR   CTD; 51124; -.
DR   ZFIN; ZDB-GENE-050506-106; ier3ip1.
DR   eggNOG; KOG4779; Eukaryota.
DR   GeneTree; ENSGT00510000047648; -.
DR   HOGENOM; CLU_152125_3_0_1; -.
DR   InParanoid; Q4VBI2; -.
DR   OMA; WASWQNV; -.
DR   OrthoDB; 1624874at2759; -.
DR   PhylomeDB; Q4VBI2; -.
DR   TreeFam; TF300263; -.
DR   PRO; PR:Q4VBI2; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 10.
DR   Bgee; ENSDARG00000039601; Expressed in mature ovarian follicle and 26 other tissues.
DR   GO; GO:0030134; C:COPII-coated ER to Golgi transport vesicle; IBA:GO_Central.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.
DR   GO; GO:0030173; C:integral component of Golgi membrane; IBA:GO_Central.
DR   GO; GO:0007420; P:brain development; ISS:UniProtKB.
DR   GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IBA:GO_Central.
DR   GO; GO:0035265; P:organ growth; ISS:UniProtKB.
DR   GO; GO:0003331; P:positive regulation of extracellular matrix constituent secretion; ISS:UniProtKB.
DR   GO; GO:0050714; P:positive regulation of protein secretion; ISS:UniProtKB.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR013880; Yos1.
DR   PANTHER; PTHR15858; PTHR15858; 1.
DR   Pfam; PF08571; Yos1; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; Membrane; Protein transport; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..82
FT                   /note="Immediate early response 3-interacting protein 1"
FT                   /id="PRO_0000257964"
FT   TRANSMEM        2..22
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        62..82
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   82 AA;  8886 MW;  18B1F2EA00334C67 CRC64;
     MAFTLYALIQ TAILFTNAIA VLHEERFLSK IGWGAEQGVG GFGDDPGIKA QLLNLIRSVR
     TVMRVPLIAV NSVCIVLLLL FG