IR3IP_MOUSE
ID IR3IP_MOUSE Reviewed; 82 AA.
AC Q9CR20;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Immediate early response 3-interacting protein 1 {ECO:0000305};
GN Name=Ier3ip1 {ECO:0000312|MGI:MGI:1913441};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:BAB23248.1};
RC TISSUE=Embryo {ECO:0000312|EMBL:BAB23248.1},
RC Pancreas {ECO:0000312|EMBL:BAB25005.1}, and
RC Tongue {ECO:0000312|EMBL:BAB26081.1};
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N {ECO:0000312|EMBL:AAH21512.1};
RC TISSUE=Mammary gland {ECO:0000312|EMBL:AAH21512.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP FUNCTION.
RX PubMed=28915629; DOI=10.18632/oncotarget.18179;
RA Sun J., Ren D.;
RT "IER3IP1 deficiency leads to increased beta-cell death and decreased beta-
RT cell proliferation.";
RL Oncotarget 8:56768-56779(2017).
CC -!- FUNCTION: Regulator of endoplasmic reticulum secretion that acts as a
CC key determinant of brain size. Required for secretion of extracellular
CC matrix proteins. Required for correct brain development by depositing
CC sufficient extracellular matrix proteins for tissue integrity and the
CC proliferation of neural progenitors (By similarity). Acts as a
CC regulator of the unfolded protein response (UPR) (PubMed:28915629).
CC {ECO:0000250|UniProtKB:Q9Y5U9, ECO:0000269|PubMed:28915629}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000250|UniProtKB:Q9Y5U9}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the YOS1 family. {ECO:0000305}.
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DR EMBL; AK004281; BAB23248.1; -; mRNA.
DR EMBL; AK007388; BAB25005.1; -; mRNA.
DR EMBL; AK007862; BAB25314.1; -; mRNA.
DR EMBL; AK009116; BAB26081.1; -; mRNA.
DR EMBL; BC021512; AAH21512.1; -; mRNA.
DR CCDS; CCDS37862.1; -.
DR RefSeq; NP_079685.1; NM_025409.3.
DR AlphaFoldDB; Q9CR20; -.
DR STRING; 10090.ENSMUSP00000026487; -.
DR PhosphoSitePlus; Q9CR20; -.
DR EPD; Q9CR20; -.
DR MaxQB; Q9CR20; -.
DR PaxDb; Q9CR20; -.
DR PRIDE; Q9CR20; -.
DR DNASU; 66191; -.
DR Ensembl; ENSMUST00000026487; ENSMUSP00000026487; ENSMUSG00000090000.
DR GeneID; 66191; -.
DR KEGG; mmu:66191; -.
DR UCSC; uc008fqr.2; mouse.
DR CTD; 51124; -.
DR MGI; MGI:1913441; Ier3ip1.
DR VEuPathDB; HostDB:ENSMUSG00000090000; -.
DR eggNOG; KOG4779; Eukaryota.
DR GeneTree; ENSGT01030000236530; -.
DR HOGENOM; CLU_152125_3_0_1; -.
DR InParanoid; Q9CR20; -.
DR OMA; WASWQNV; -.
DR OrthoDB; 1624874at2759; -.
DR PhylomeDB; Q9CR20; -.
DR TreeFam; TF300263; -.
DR BioGRID-ORCS; 66191; 12 hits in 70 CRISPR screens.
DR ChiTaRS; Ier3ip1; mouse.
DR PRO; PR:Q9CR20; -.
DR Proteomes; UP000000589; Chromosome 18.
DR RNAct; Q9CR20; protein.
DR Bgee; ENSMUSG00000090000; Expressed in humerus cartilage element and 266 other tissues.
DR ExpressionAtlas; Q9CR20; baseline and differential.
DR Genevisible; Q9CR20; MM.
DR GO; GO:0030134; C:COPII-coated ER to Golgi transport vesicle; IBA:GO_Central.
DR GO; GO:0005783; C:endoplasmic reticulum; ISO:MGI.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.
DR GO; GO:0005794; C:Golgi apparatus; ISO:MGI.
DR GO; GO:0030173; C:integral component of Golgi membrane; IBA:GO_Central.
DR GO; GO:0007420; P:brain development; ISS:UniProtKB.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IBA:GO_Central.
DR GO; GO:0035265; P:organ growth; ISS:UniProtKB.
DR GO; GO:0003331; P:positive regulation of extracellular matrix constituent secretion; ISS:UniProtKB.
DR GO; GO:0050714; P:positive regulation of protein secretion; ISS:UniProtKB.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:2000269; P:regulation of fibroblast apoptotic process; ISS:UniProtKB.
DR InterPro; IPR013880; Yos1.
DR PANTHER; PTHR15858; PTHR15858; 1.
DR Pfam; PF08571; Yos1; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum; Membrane; Protein transport; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..82
FT /note="Immediate early response 3-interacting protein 1"
FT /id="PRO_0000257962"
FT TRANSMEM 2..22
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 62..82
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 82 AA; 9017 MW; 3015F654F1EBB080 CRC64;
MAFTLYSLMQ AALLCVNAIA VLHEERFLKN IGWGTDQGIG GFGEEPGIKS QLMNLIRSVR
TVMRVPLIIV NSITIVLLLL FG
