ID   IR3IP_XENLA             Reviewed;          82 AA.
AC   Q3B8G7;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 49.
DE   RecName: Full=Immediate early response 3-interacting protein 1 {ECO:0000305};
GN   Name=ier3ip1 {ECO:0000250|UniProtKB:Q9Y5U9};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis {ECO:0000312|EMBL:AAI06449.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulator of endoplasmic reticulum secretion that acts as a
CC       key determinant of brain size. Required for secretion of extracellular
CC       matrix proteins. Required for correct brain development by depositing
CC       sufficient extracellular matrix proteins for tissue integrity and the
CC       proliferation of neural progenitors (By similarity). Acts as a
CC       regulator of the unfolded protein response (UPR) (By similarity).
CC       {ECO:0000250|UniProtKB:Q9CR20, ECO:0000250|UniProtKB:Q9Y5U9}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:Q9Y5U9}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the YOS1 family. {ECO:0000305}.
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DR   EMBL; BC106448; AAI06449.1; -; mRNA.
DR   RefSeq; NP_001153213.1; NM_001159741.1.
DR   AlphaFoldDB; Q3B8G7; -.
DR   SMR; Q3B8G7; -.
DR   DNASU; 735184; -.
DR   GeneID; 735184; -.
DR   KEGG; xla:735184; -.
DR   CTD; 735184; -.
DR   Xenbase; XB-GENE-6254264; ier3ip1.L.
DR   OMA; WASWQNV; -.
DR   OrthoDB; 1624874at2759; -.
DR   Proteomes; UP000186698; Chromosome 1L.
DR   Bgee; 735184; Expressed in pancreas and 19 other tissues.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0007420; P:brain development; ISS:UniProtKB.
DR   GO; GO:0035265; P:organ growth; ISS:UniProtKB.
DR   GO; GO:0003331; P:positive regulation of extracellular matrix constituent secretion; ISS:UniProtKB.
DR   GO; GO:0050714; P:positive regulation of protein secretion; ISS:UniProtKB.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR013880; Yos1.
DR   PANTHER; PTHR15858; PTHR15858; 1.
DR   Pfam; PF08571; Yos1; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; Membrane; Protein transport; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..82
FT                   /note="Immediate early response 3-interacting protein 1"
FT                   /id="PRO_0000257965"
FT   TRANSMEM        2..22
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        62..82
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   82 AA;  8983 MW;  FA92DDD9D165D1CC CRC64;
     MAFTLYTLLQ AALLCVNAVA VLHEERFLSK IGWGVDHGIG GFGEEPGMKS QLMNLIRSVR
     TVMRVPLIIV NSVTIVLLLL FG