IR75A_DROSE
ID IR75A_DROSE Reviewed; 629 AA.
AC A0A1J0M738; B4HKX2;
DT 18-JUL-2018, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2017, sequence version 1.
DT 23-FEB-2022, entry version 21.
DE RecName: Full=Ionotropic receptor 75a {ECO:0000303|PubMed:27776356};
GN Name=IR75a {ECO:0000303|PubMed:27776356}; ORFNames=GM24303;
OS Drosophila sechellia (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7238 {ECO:0000312|EMBL:APD16194.1};
RN [1] {ECO:0000312|EMBL:APD16194.1}
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=27776356; DOI=10.1038/nature19824;
RA Prieto-Godino L.L., Rytz R., Bargeton B., Abuin L., Arguello J.R.,
RA Peraro M.D., Benton R.;
RT "Olfactory receptor pseudo-pseudogenes.";
RL Nature 539:93-97(2016).
RN [2] {ECO:0000312|Proteomes:UP000001292}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Rob3c / Tucson 14021-0248.25 {ECO:0000312|Proteomes:UP000001292};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: Olfactory receptor for propionic, butyric and 2-oxopentanoic
CC acids. {ECO:0000269|PubMed:27776356}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:27776356};
CC Multi-pass membrane protein {ECO:0000255}. Cell projection, dendrite
CC {ECO:0000269|PubMed:27776356}.
CC -!- TISSUE SPECIFICITY: Expressed in neurons in the antennal coeloconic 2
CC (ac2) sensillum class of sensory hairs (at protein level).
CC {ECO:0000269|PubMed:27776356}.
CC -!- MISCELLANEOUS: This protein is translated by readthrough of a stop
CC codon only in neurons. Readthrough of the terminator codon TAA occurs
CC between the codons for Thr-213 and Arg-215. There is currently no
CC protein sequence that provides the identity of residue 214.
CC {ECO:0000305|PubMed:27776356}.
CC -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EDW41927.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; KX694389; APD16194.1; -; mRNA.
DR EMBL; CH480815; EDW41927.1; ALT_SEQ; Genomic_DNA.
DR RefSeq; XP_002030941.1; XM_002030905.1.
DR STRING; 7238.A0A1J0M738; -.
DR HOGENOM; CLU_015993_3_0_1; -.
DR Proteomes; UP000001292; Unassembled WGS sequence.
DR GO; GO:0044297; C:cell body; IDA:UniProtKB.
DR GO; GO:0030425; C:dendrite; IDA:UniProtKB.
DR GO; GO:0005887; C:integral component of plasma membrane; IEA:EnsemblMetazoa.
DR GO; GO:0071683; C:sensory dendrite; IEA:EnsemblMetazoa.
DR GO; GO:0005230; F:extracellular ligand-gated ion channel activity; IEA:EnsemblMetazoa.
DR GO; GO:0004984; F:olfactory receptor activity; IMP:UniProtKB.
DR GO; GO:0050911; P:detection of chemical stimulus involved in sensory perception of smell; IMP:UniProtKB.
DR GO; GO:0007605; P:sensory perception of sound; IEA:EnsemblMetazoa.
DR InterPro; IPR001320; Iontro_rcpt.
DR Pfam; PF00060; Lig_chan; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Cell projection; Glycoprotein; Membrane; Olfaction;
KW Receptor; Reference proteome; Sensory transduction; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..629
FT /note="Ionotropic receptor 75a"
FT /evidence="ECO:0000305"
FT /id="PRO_0000444756"
FT TOPO_DOM 1..335
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 336..356
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 357..374
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 375..395
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 396..402
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 403..423
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 424..592
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 593..613
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 614..629
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT CARBOHYD 61
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 112
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 126
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 144
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 166
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 232
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ SEQUENCE 629 AA; 72622 MW; 5CB09CEBB5E0253E CRC64;
MQLVQLANFV LDNLVQSRIG FIVLFHCWQS DESLKFAEQF MKPIHPILVY HQFVQMRGVL
NWSHLELNYM GHTQPTLAIY VDIKCDQAQD LLEEASREQI YNQHYHWLLV GNQSELEFND
LFALFNISID ADVSYVKEQI QDNNDSVAYA VYDVYNNGKI IGGQLNVTGS HEMSCDPFKC
RRTRYLSSLQ KRSKYGNREQ LTDVVLRVAT VVTXRPLTLS DDELIRFLSQ ENDTHIDSLA
RFGFHLTLIL RDLLYCKMKF IFSDSWSKSD VVGGSVGAVV DQTADLTASP SLATEGRLKY
LSAIIETGFF RSVCIFRTPH NAGLRGDVFL QPFSPLVWYL FGGVLSLIGV LLWITFYMEC
KRMQKRWRLD YLPSLLSTFL ISFGAACIQS SSLIPRSAGG RLIYFALFLI SFIMYNYYTS
VVVSSLLSSP VKSKIKTMQQ LAESSLTVGL EPLPFTKSYL NYSRLPEIHL FIKRKIESQT
QNPELWLPAE QGVLRVKANP GYVYVFETSS GYAYVERYFT AQEICDLNEV LFRPEKLLYT
HLHRNSTYKE LFRLRFLRIL ETGVYRKQRS YWVHMKLHCE AQNFVITVGM EYVAPLLLML
ICADILVVVI LLVELAWKRF FTRPLTIHP
