IRAD_ECO24
ID IRAD_ECO24 Reviewed; 130 AA.
AC A7ZVM4;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 10-JUN-2008, sequence version 2.
DT 25-MAY-2022, entry version 57.
DE RecName: Full=Anti-adapter protein IraD {ECO:0000255|HAMAP-Rule:MF_02010};
GN Name=iraD {ECO:0000255|HAMAP-Rule:MF_02010};
GN OrderedLocusNames=EcE24377A_4926;
OS Escherichia coli O139:H28 (strain E24377A / ETEC).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=331111;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=E24377A / ETEC;
RX PubMed=18676672; DOI=10.1128/jb.00619-08;
RA Rasko D.A., Rosovitz M.J., Myers G.S.A., Mongodin E.F., Fricke W.F.,
RA Gajer P., Crabtree J., Sebaihia M., Thomson N.R., Chaudhuri R.,
RA Henderson I.R., Sperandio V., Ravel J.;
RT "The pangenome structure of Escherichia coli: comparative genomic analysis
RT of E. coli commensal and pathogenic isolates.";
RL J. Bacteriol. 190:6881-6893(2008).
CC -!- FUNCTION: Inhibits RpoS proteolysis by regulating RssB activity,
CC thereby increasing the stability of the sigma stress factor RpoS during
CC oxidative stress. Its effect on RpoS stability is due to its
CC interaction with RssB, which probably blocks the interaction of RssB
CC with RpoS, and the consequent delivery of the RssB-RpoS complex to the
CC ClpXP protein degradation pathway. {ECO:0000255|HAMAP-Rule:MF_02010}.
CC -!- SUBUNIT: Interacts with RssB. {ECO:0000255|HAMAP-Rule:MF_02010}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_02010}.
CC -!- SIMILARITY: Belongs to the GpW/Gp25 family. IraD subfamily.
CC {ECO:0000255|HAMAP-Rule:MF_02010}.
CC -!- SEQUENCE CAUTION:
CC Sequence=ABV19943.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; CP000800; ABV19943.1; ALT_INIT; Genomic_DNA.
DR RefSeq; WP_000986215.1; NC_009801.1.
DR AlphaFoldDB; A7ZVM4; -.
DR SMR; A7ZVM4; -.
DR EnsemblBacteria; ABV19943; ABV19943; EcE24377A_4926.
DR KEGG; ecw:EcE24377A_4926; -.
DR HOGENOM; CLU_1977621_0_0_6; -.
DR Proteomes; UP000001122; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0043856; F:anti-sigma factor antagonist activity; IEA:InterPro.
DR GO; GO:0006974; P:cellular response to DNA damage stimulus; IEA:InterPro.
DR GO; GO:0034599; P:cellular response to oxidative stress; IEA:UniProtKB-UniRule.
DR HAMAP; MF_02010; IraD; 1.
DR InterPro; IPR023776; Anti-adapt_IraD.
DR InterPro; IPR007048; IraD/Gp25-like.
DR Pfam; PF04965; GPW_gp25; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Stress response.
FT CHAIN 1..130
FT /note="Anti-adapter protein IraD"
FT /id="PRO_0000337891"
SQ SEQUENCE 130 AA; 14747 MW; 8CDC09EAE074A3F0 CRC64;
MMRQSLQAVL PEISGNKTSP LRKSVCSDLL TLFNSPHSAL PSLLVSGMPE WQVHNPSDKH
LQSWYCRQLR SALLFHEPRI AALQVNLKEA YCHTLAISLE IMLYHDDESL TFDLVWDNGG
WRSATLENVS