ID   IRAD_SALCH              Reviewed;         126 AA.
AC   Q57JY6;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Anti-adapter protein IraD {ECO:0000255|HAMAP-Rule:MF_02010};
GN   Name=iraD {ECO:0000255|HAMAP-Rule:MF_02010}; OrderedLocusNames=SCH_3070;
OS   Salmonella choleraesuis (strain SC-B67).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=321314;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC-B67;
RX   PubMed=15781495; DOI=10.1093/nar/gki297;
RA   Chiu C.-H., Tang P., Chu C., Hu S., Bao Q., Yu J., Chou Y.-Y., Wang H.-S.,
RA   Lee Y.-S.;
RT   "The genome sequence of Salmonella enterica serovar Choleraesuis, a highly
RT   invasive and resistant zoonotic pathogen.";
RL   Nucleic Acids Res. 33:1690-1698(2005).
CC   -!- FUNCTION: Inhibits RpoS proteolysis by regulating RssB activity,
CC       thereby increasing the stability of the sigma stress factor RpoS during
CC       oxidative stress. Its effect on RpoS stability is due to its
CC       interaction with RssB, which probably blocks the interaction of RssB
CC       with RpoS, and the consequent delivery of the RssB-RpoS complex to the
CC       ClpXP protein degradation pathway. {ECO:0000255|HAMAP-Rule:MF_02010}.
CC   -!- SUBUNIT: Interacts with RssB. {ECO:0000255|HAMAP-Rule:MF_02010}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_02010}.
CC   -!- SIMILARITY: Belongs to the GpW/Gp25 family. IraD subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_02010}.
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DR   EMBL; AE017220; AAX66976.1; -; Genomic_DNA.
DR   RefSeq; WP_001540910.1; NC_006905.1.
DR   AlphaFoldDB; Q57JY6; -.
DR   SMR; Q57JY6; -.
DR   EnsemblBacteria; AAX66976; AAX66976; SCH_3070.
DR   KEGG; sec:SCH_3070; -.
DR   HOGENOM; CLU_1977621_0_0_6; -.
DR   OMA; FKEAYCH; -.
DR   Proteomes; UP000000538; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0043856; F:anti-sigma factor antagonist activity; IEA:InterPro.
DR   GO; GO:0006974; P:cellular response to DNA damage stimulus; IEA:InterPro.
DR   GO; GO:0034599; P:cellular response to oxidative stress; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_02010; IraD; 1.
DR   InterPro; IPR023776; Anti-adapt_IraD.
DR   InterPro; IPR007048; IraD/Gp25-like.
DR   Pfam; PF04965; GPW_gp25; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Stress response.
FT   CHAIN           1..126
FT                   /note="Anti-adapter protein IraD"
FT                   /id="PRO_0000337898"
SQ   SEQUENCE   126 AA;  14452 MW;  F8F385F74B9C2141 CRC64;
     MMTPTIPVAL FDRLLVEGIS PHELVRRKLM CLFNSCSVPG GETLPPLLTR GMPEWHEVNV
     GDKRVLNWFC RELRAAILRY EPSINMLKVS VKDAHHQTLA LSLEAMLQDE SEPLRLEIAY
     SNGRWR