ID   IRAD_SHIFL              Reviewed;         130 AA.
AC   Q83P77; Q7UAR1;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-JUN-2008, sequence version 5.
DT   25-MAY-2022, entry version 100.
DE   RecName: Full=Anti-adapter protein IraD {ECO:0000255|HAMAP-Rule:MF_02010};
GN   Name=iraD {ECO:0000255|HAMAP-Rule:MF_02010};
GN   OrderedLocusNames=SF4192, S4448;
OS   Shigella flexneri.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=301 / Serotype 2a;
RX   PubMed=12384590; DOI=10.1093/nar/gkf566;
RA   Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA   Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA   Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA   Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT   "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT   through comparison with genomes of Escherichia coli K12 and O157.";
RL   Nucleic Acids Res. 30:4432-4441(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX   PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA   Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA   Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA   Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT   "Complete genome sequence and comparative genomics of Shigella flexneri
RT   serotype 2a strain 2457T.";
RL   Infect. Immun. 71:2775-2786(2003).
CC   -!- FUNCTION: Inhibits RpoS proteolysis by regulating RssB activity,
CC       thereby increasing the stability of the sigma stress factor RpoS during
CC       oxidative stress. Its effect on RpoS stability is due to its
CC       interaction with RssB, which probably blocks the interaction of RssB
CC       with RpoS, and the consequent delivery of the RssB-RpoS complex to the
CC       ClpXP protein degradation pathway. {ECO:0000255|HAMAP-Rule:MF_02010}.
CC   -!- SUBUNIT: Interacts with RssB. {ECO:0000255|HAMAP-Rule:MF_02010}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_02010}.
CC   -!- SIMILARITY: Belongs to the GpW/Gp25 family. IraD subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_02010}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAN45613.2; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=AAP19399.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE005674; AAN45613.2; ALT_INIT; Genomic_DNA.
DR   EMBL; AE014073; AAP19399.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; NP_709906.2; NC_004337.2.
DR   RefSeq; WP_000986206.1; NZ_WPGW01000192.1.
DR   AlphaFoldDB; Q83P77; -.
DR   SMR; Q83P77; -.
DR   STRING; 198214.SF4192; -.
DR   DNASU; 1080655; -.
DR   EnsemblBacteria; AAN45613; AAN45613; SF4192.
DR   EnsemblBacteria; AAP19399; AAP19399; S4448.
DR   GeneID; 1025039; -.
DR   GeneID; 58390267; -.
DR   KEGG; sfl:SF4192; -.
DR   KEGG; sfx:S4448; -.
DR   PATRIC; fig|198214.7.peg.4945; -.
DR   HOGENOM; CLU_1977621_0_0_6; -.
DR   OrthoDB; 1858491at2; -.
DR   Proteomes; UP000001006; Chromosome.
DR   Proteomes; UP000002673; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0043856; F:anti-sigma factor antagonist activity; IEA:InterPro.
DR   GO; GO:0006974; P:cellular response to DNA damage stimulus; IEA:InterPro.
DR   GO; GO:0034599; P:cellular response to oxidative stress; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_02010; IraD; 1.
DR   InterPro; IPR023776; Anti-adapt_IraD.
DR   InterPro; IPR007048; IraD/Gp25-like.
DR   Pfam; PF04965; GPW_gp25; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Reference proteome; Stress response.
FT   CHAIN           1..130
FT                   /note="Anti-adapter protein IraD"
FT                   /id="PRO_0000337903"
SQ   SEQUENCE   130 AA;  14773 MW;  7CDC09EAF52394A1 CRC64;
     MMRQSLQAVL PEISGNKTSL LRKSVCSDLL TLFNSPHSAL PSLLVSGMPE WQVHNPSDKH
     LQSWYCRQLR SALLFHEPRI AALQVNLKEA YCHTLAISLE IMLYHDDEPL TFDLVWDNGG
     WRSATLENVS