IRAK2_BOVIN
ID IRAK2_BOVIN Reviewed; 621 AA.
AC Q0P5I2;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 19-SEP-2006, sequence version 1.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=Interleukin-1 receptor-associated kinase-like 2;
DE Short=IRAK-2;
GN Name=IRAK2;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Fetal liver;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Binds to the IL-1 type I receptor following IL-1 engagement,
CC triggering intracellular signaling cascades leading to transcriptional
CC up-regulation and mRNA stabilization. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with MYD88. IL-1 stimulation leads to the formation
CC of a signaling complex which dissociates from the IL-1 receptor
CC following the binding of PELI1 (By similarity). {ECO:0000250}.
CC -!- DOMAIN: The protein kinase domain is predicted to be catalytically
CC inactive.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. TKL Ser/Thr
CC protein kinase family. Pelle subfamily. {ECO:0000305}.
CC -!- CAUTION: Asn-331 is present instead of the conserved Asp which is
CC expected to be an active site residue. {ECO:0000305}.
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DR EMBL; BC120001; AAI20002.1; -; mRNA.
DR RefSeq; NP_001069164.1; NM_001075696.2.
DR AlphaFoldDB; Q0P5I2; -.
DR SMR; Q0P5I2; -.
DR STRING; 9913.ENSBTAP00000008135; -.
DR PaxDb; Q0P5I2; -.
DR Ensembl; ENSBTAT00000008135; ENSBTAP00000008135; ENSBTAG00000006193.
DR GeneID; 515034; -.
DR KEGG; bta:515034; -.
DR CTD; 3656; -.
DR VEuPathDB; HostDB:ENSBTAG00000006193; -.
DR VGNC; VGNC:30266; IRAK2.
DR eggNOG; KOG1187; Eukaryota.
DR GeneTree; ENSGT00940000159835; -.
DR InParanoid; Q0P5I2; -.
DR OMA; ALSEWDW; -.
DR OrthoDB; 684563at2759; -.
DR TreeFam; TF328924; -.
DR Proteomes; UP000009136; Chromosome 22.
DR Bgee; ENSBTAG00000006193; Expressed in choroid plexus and 103 other tissues.
DR ExpressionAtlas; Q0P5I2; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:Ensembl.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR GO; GO:0004672; F:protein kinase activity; IBA:GO_Central.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IBA:GO_Central.
DR GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0007249; P:I-kappaB kinase/NF-kappaB signaling; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR GO; GO:0070498; P:interleukin-1-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0035556; P:intracellular signal transduction; IBA:GO_Central.
DR GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IEA:Ensembl.
DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro.
DR GO; GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; IEA:Ensembl.
DR GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IBA:GO_Central.
DR GO; GO:0006468; P:protein phosphorylation; IEA:InterPro.
DR GO; GO:0001959; P:regulation of cytokine-mediated signaling pathway; IEA:Ensembl.
DR CDD; cd08795; Death_IRAK2; 1.
DR Gene3D; 1.10.533.10; -; 1.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR042151; Death_IRAK2.
DR InterPro; IPR033611; IRAK2.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR PANTHER; PTHR24419:SF2; PTHR24419:SF2; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SUPFAM; SSF47986; SSF47986; 1.
DR SUPFAM; SSF56112; SSF56112; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; Nucleotide-binding; Reference proteome.
FT CHAIN 1..621
FT /note="Interleukin-1 receptor-associated kinase-like 2"
FT /id="PRO_0000277559"
FT DOMAIN 13..94
FT /note="Death"
FT DOMAIN 206..476
FT /note="Protein kinase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT REGION 113..175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 503..534
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 156..175
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 212..220
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT BINDING 233
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT BINDING 333..336
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
SQ SEQUENCE 621 AA; 68630 MW; 8641DDD096BD993F CRC64;
MSCYIYQLPS WVLDDLCRNM DTLSEWDWMQ FASYVITDLT QLRKIKSMER AQGVSITREL
LWWWGMRQAT VQQLLDLLCH LELYRAAQII LNWKPVLEVK SSIPDFSDTV KPGKPLAASV
RNTEDKQETG QPVRPPTFPG SGPAAVRVNL PAPPEDASSS LKTNQTASAD SKDFSASIPK
QETLSSLAGD DLFWSEVDVI QATDNFNPSH KISEGTFADV YRGHKRGTPF IFKKLREMAC
SGPGSVEKFF QAEVQICRRC CHPNVLPLLG CCTGEQFYSL IYPYMANGSL QDRLQGQGGS
DPLPWPQRIS ICSGLLHAVE HLHSLEIIHG NVKSSNVLLD QNFTPKLAHS MAHPCPVNRT
SKYTMMKTHL FQASTAYLPE DFIRVGQLTK RVDIFSCGIV LAEVLTGIPA MDNNRNPVYL
KDLLLHEIPS STISLCSRKM GVEKEMAKEI CQKYLEKRAG RLPEAHAEAL VMAACLCLRR
RNASLAEVCS SVAAVEEQLR GQETSLPCSG LSEGTGSSFN TPEETDDVDN SSFDGSYSMR
AAPWAGATSS PPLTADEEGM LLAGGAVEAD SSAEACAPPE PPQDATETSW KIEINEAKRK
LMENILLYKE EKLDSIELFG P
