ID   IRAP_ECOLU              Reviewed;          86 AA.
AC   B7N8T4;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 1.
DT   25-MAY-2022, entry version 52.
DE   RecName: Full=Anti-adapter protein IraP {ECO:0000255|HAMAP-Rule:MF_01198};
GN   Name=iraP {ECO:0000255|HAMAP-Rule:MF_01198}; OrderedLocusNames=ECUMN_0420;
OS   Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=585056;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UMN026 / ExPEC;
RX   PubMed=19165319; DOI=10.1371/journal.pgen.1000344;
RA   Touchon M., Hoede C., Tenaillon O., Barbe V., Baeriswyl S., Bidet P.,
RA   Bingen E., Bonacorsi S., Bouchier C., Bouvet O., Calteau A., Chiapello H.,
RA   Clermont O., Cruveiller S., Danchin A., Diard M., Dossat C., Karoui M.E.,
RA   Frapy E., Garry L., Ghigo J.M., Gilles A.M., Johnson J., Le Bouguenec C.,
RA   Lescat M., Mangenot S., Martinez-Jehanne V., Matic I., Nassif X., Oztas S.,
RA   Petit M.A., Pichon C., Rouy Z., Ruf C.S., Schneider D., Tourret J.,
RA   Vacherie B., Vallenet D., Medigue C., Rocha E.P.C., Denamur E.;
RT   "Organised genome dynamics in the Escherichia coli species results in
RT   highly diverse adaptive paths.";
RL   PLoS Genet. 5:E1000344-E1000344(2009).
CC   -!- FUNCTION: Inhibits RpoS proteolysis by regulating RssB activity,
CC       thereby increasing the stability of the sigma stress factor RpoS
CC       especially during phosphate starvation, but also in stationary phase
CC       and during nitrogen starvation. Its effect on RpoS stability is due to
CC       its interaction with RssB, which probably blocks the interaction of
CC       RssB with RpoS, and the consequent delivery of the RssB-RpoS complex to
CC       the ClpXP protein degradation pathway. {ECO:0000255|HAMAP-
CC       Rule:MF_01198}.
CC   -!- SUBUNIT: Interacts with RssB. {ECO:0000255|HAMAP-Rule:MF_01198}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01198}.
CC   -!- SIMILARITY: Belongs to the IraP family. {ECO:0000255|HAMAP-
CC       Rule:MF_01198}.
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DR   EMBL; CU928163; CAR11635.1; -; Genomic_DNA.
DR   RefSeq; WP_000792975.1; NC_011751.1.
DR   RefSeq; YP_002411183.1; NC_011751.1.
DR   AlphaFoldDB; B7N8T4; -.
DR   SMR; B7N8T4; -.
DR   STRING; 585056.ECUMN_0420; -.
DR   EnsemblBacteria; CAR11635; CAR11635; ECUMN_0420.
DR   KEGG; eum:ECUMN_0420; -.
DR   PATRIC; fig|585056.7.peg.619; -.
DR   HOGENOM; CLU_169517_0_0_6; -.
DR   OMA; IDTAMIH; -.
DR   Proteomes; UP000007097; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009267; P:cellular response to starvation; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01198; Anti_adapt_IraP; 1.
DR   InterPro; IPR019732; SigmaS_Anti-adapt_IraP.
DR   Pfam; PF10796; Anti-adapt_IraP; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Cytoplasm; Stress response.
FT   CHAIN           1..86
FT                   /note="Anti-adapter protein IraP"
FT                   /id="PRO_1000138486"
FT   COILED          1..36
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01198"
SQ   SEQUENCE   86 AA;  9936 MW;  1C2EE0101DB16BEE CRC64;
     MKNLIAELLF KLAQKEEESK ELCAQVEALE IIVTAMLRNM AQNDQQRLID QVEGALYEVK
     PDASIPDDDT ELLRNYVKKL LKHPRQ