IRAP_KLEP3
ID IRAP_KLEP3 Reviewed; 86 AA.
AC B5Y119;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 25-NOV-2008, sequence version 1.
DT 25-MAY-2022, entry version 53.
DE RecName: Full=Anti-adapter protein IraP {ECO:0000255|HAMAP-Rule:MF_01198};
GN Name=iraP {ECO:0000255|HAMAP-Rule:MF_01198}; OrderedLocusNames=KPK_4360;
OS Klebsiella pneumoniae (strain 342).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX NCBI_TaxID=507522;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=342;
RX PubMed=18654632; DOI=10.1371/journal.pgen.1000141;
RA Fouts D.E., Tyler H.L., DeBoy R.T., Daugherty S., Ren Q., Badger J.H.,
RA Durkin A.S., Huot H., Shrivastava S., Kothari S., Dodson R.J., Mohamoud Y.,
RA Khouri H., Roesch L.F.W., Krogfelt K.A., Struve C., Triplett E.W.,
RA Methe B.A.;
RT "Complete genome sequence of the N2-fixing broad host range endophyte
RT Klebsiella pneumoniae 342 and virulence predictions verified in mice.";
RL PLoS Genet. 4:E1000141-E1000141(2008).
CC -!- FUNCTION: Inhibits RpoS proteolysis by regulating RssB activity,
CC thereby increasing the stability of the sigma stress factor RpoS
CC especially during phosphate starvation, but also in stationary phase
CC and during nitrogen starvation. Its effect on RpoS stability is due to
CC its interaction with RssB, which probably blocks the interaction of
CC RssB with RpoS, and the consequent delivery of the RssB-RpoS complex to
CC the ClpXP protein degradation pathway. {ECO:0000255|HAMAP-
CC Rule:MF_01198}.
CC -!- SUBUNIT: Interacts with RssB. {ECO:0000255|HAMAP-Rule:MF_01198}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01198}.
CC -!- SIMILARITY: Belongs to the IraP family. {ECO:0000255|HAMAP-
CC Rule:MF_01198}.
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DR EMBL; CP000964; ACI09830.1; -; Genomic_DNA.
DR AlphaFoldDB; B5Y119; -.
DR EnsemblBacteria; ACI09830; ACI09830; KPK_4360.
DR KEGG; kpe:KPK_4360; -.
DR HOGENOM; CLU_169517_0_0_6; -.
DR OMA; IDTAMIH; -.
DR OrthoDB; 2029093at2; -.
DR Proteomes; UP000001734; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009267; P:cellular response to starvation; IEA:UniProtKB-UniRule.
DR HAMAP; MF_01198; Anti_adapt_IraP; 1.
DR InterPro; IPR019732; SigmaS_Anti-adapt_IraP.
DR Pfam; PF10796; Anti-adapt_IraP; 1.
PE 3: Inferred from homology;
KW Coiled coil; Cytoplasm; Stress response.
FT CHAIN 1..86
FT /note="Anti-adapter protein IraP"
FT /id="PRO_1000138489"
FT COILED 1..38
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01198"
SQ SEQUENCE 86 AA; 9836 MW; 2ABB3B00A72E4D29 CRC64;
MKNLIAELLV KLAQKEEEAK ELTVQVEALE IVVTALLRHM EHDAQQALIQ DIEQAIDQVT
PCPPVNDQDA MLLQQYLKKL LRHPRS