IRAP_SALAR
ID IRAP_SALAR Reviewed; 86 AA.
AC A9MMS6;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 10-JUN-2008, sequence version 2.
DT 25-MAY-2022, entry version 48.
DE RecName: Full=Anti-adapter protein IraP {ECO:0000255|HAMAP-Rule:MF_01198};
GN Name=iraP {ECO:0000255|HAMAP-Rule:MF_01198}; OrderedLocusNames=SARI_02543;
OS Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=41514;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-731 / CDC346-86 / RSK2980;
RG The Salmonella enterica serovar Arizonae Genome Sequencing Project;
RA McClelland M., Sanderson E.K., Porwollik S., Spieth J., Clifton W.S.,
RA Fulton R., Chunyan W., Wollam A., Shah N., Pepin K., Bhonagiri V., Nash W.,
RA Johnson M., Thiruvilangam P., Wilson R.;
RL Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Inhibits RpoS proteolysis by regulating RssB activity,
CC thereby increasing the stability of the sigma stress factor RpoS
CC especially during phosphate and magnesium starvation, but also in
CC stationary phase and during nitrogen starvation. Its effect on RpoS
CC stability is due to its interaction with RssB, which probably blocks
CC the interaction of RssB with RpoS, and the consequent delivery of the
CC RssB-RpoS complex to the ClpXP protein degradation pathway.
CC {ECO:0000255|HAMAP-Rule:MF_01198}.
CC -!- SUBUNIT: Interacts with RssB. {ECO:0000255|HAMAP-Rule:MF_01198}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01198}.
CC -!- SIMILARITY: Belongs to the IraP family. {ECO:0000255|HAMAP-
CC Rule:MF_01198}.
CC -!- SEQUENCE CAUTION:
CC Sequence=ABX22401.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; CP000880; ABX22401.1; ALT_INIT; Genomic_DNA.
DR AlphaFoldDB; A9MMS6; -.
DR SMR; A9MMS6; -.
DR STRING; 41514.SARI_02543; -.
DR EnsemblBacteria; ABX22401; ABX22401; SARI_02543.
DR KEGG; ses:SARI_02543; -.
DR HOGENOM; CLU_169517_0_0_6; -.
DR Proteomes; UP000002084; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009267; P:cellular response to starvation; IEA:UniProtKB-UniRule.
DR HAMAP; MF_01198; Anti_adapt_IraP; 1.
DR InterPro; IPR019732; SigmaS_Anti-adapt_IraP.
DR Pfam; PF10796; Anti-adapt_IraP; 1.
PE 3: Inferred from homology;
KW Coiled coil; Cytoplasm; Reference proteome; Stress response.
FT CHAIN 1..86
FT /note="Anti-adapter protein IraP"
FT /id="PRO_0000337858"
FT COILED 1..47
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01198"
SQ SEQUENCE 86 AA; 9855 MW; 0FC1079843760B4C CRC64;
MKNLIAELLL KLAQKEEESK ELVAQVEALE IIVTAMLRNM AQSEQQMLIR QVEGALEGVK
PDASVPDHDT ELLRQYVKKL LRHPRH