ID   IRAP_SALPK              Reviewed;          86 AA.
AC   B5BDF0;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 55.
DE   RecName: Full=Anti-adapter protein IraP {ECO:0000255|HAMAP-Rule:MF_01198};
GN   Name=iraP {ECO:0000255|HAMAP-Rule:MF_01198}; OrderedLocusNames=SSPA2183;
OS   Salmonella paratyphi A (strain AKU_12601).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=554290;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AKU_12601;
RX   PubMed=19159446; DOI=10.1186/1471-2164-10-36;
RA   Holt K.E., Thomson N.R., Wain J., Langridge G.C., Hasan R., Bhutta Z.A.,
RA   Quail M.A., Norbertczak H., Walker D., Simmonds M., White B., Bason N.,
RA   Mungall K., Dougan G., Parkhill J.;
RT   "Pseudogene accumulation in the evolutionary histories of Salmonella
RT   enterica serovars Paratyphi A and Typhi.";
RL   BMC Genomics 10:36-36(2009).
CC   -!- FUNCTION: Inhibits RpoS proteolysis by regulating RssB activity,
CC       thereby increasing the stability of the sigma stress factor RpoS
CC       especially during phosphate and magnesium starvation, but also in
CC       stationary phase and during nitrogen starvation. Its effect on RpoS
CC       stability is due to its interaction with RssB, which probably blocks
CC       the interaction of RssB with RpoS, and the consequent delivery of the
CC       RssB-RpoS complex to the ClpXP protein degradation pathway.
CC       {ECO:0000255|HAMAP-Rule:MF_01198}.
CC   -!- SUBUNIT: Interacts with RssB. {ECO:0000255|HAMAP-Rule:MF_01198}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01198}.
CC   -!- SIMILARITY: Belongs to the IraP family. {ECO:0000255|HAMAP-
CC       Rule:MF_01198}.
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DR   EMBL; FM200053; CAR60393.1; -; Genomic_DNA.
DR   RefSeq; WP_001518423.1; NC_011147.1.
DR   AlphaFoldDB; B5BDF0; -.
DR   SMR; B5BDF0; -.
DR   KEGG; sek:SSPA2183; -.
DR   HOGENOM; CLU_169517_0_0_6; -.
DR   OMA; IDTAMIH; -.
DR   Proteomes; UP000001869; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009267; P:cellular response to starvation; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01198; Anti_adapt_IraP; 1.
DR   InterPro; IPR019732; SigmaS_Anti-adapt_IraP.
DR   Pfam; PF10796; Anti-adapt_IraP; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Cytoplasm; Stress response.
FT   CHAIN           1..86
FT                   /note="Anti-adapter protein IraP"
FT                   /id="PRO_1000138494"
FT   COILED          1..36
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01198"
SQ   SEQUENCE   86 AA;  9883 MW;  1F904287C95EB24C CRC64;
     MKNLIAELLL KLAQKEEESK ELVAQVEALE IIVTAMLRNM AQNEQEMLIR QVEGALEGVK
     PDASVPDHDT ELLRQYVKKL LRHPRH