ID   IRAP_SALTY              Reviewed;          86 AA.
AC   Q7CR46;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-JUN-2008, sequence version 2.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Anti-adapter protein IraP;
GN   Name=iraP; OrderedLocusNames=STM0383;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
RN   [2]
RP   FUNCTION, AND INDUCTION.
RC   STRAIN=ATCC 14028s / SGSG 2262;
RX   PubMed=16938894; DOI=10.1073/pnas.0606026103;
RA   Tu X., Latifi T., Bougdour A., Gottesman S., Groisman E.A.;
RT   "The PhoP/PhoQ two-component system stabilizes the alternative sigma factor
RT   RpoS in Salmonella enterica.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:13503-13508(2006).
CC   -!- FUNCTION: Inhibits RpoS proteolysis by regulating RssB activity,
CC       thereby increasing the stability of the sigma stress factor RpoS
CC       especially during phosphate and magnesium starvation, but also in
CC       stationary phase and during nitrogen starvation. Its effect on RpoS
CC       stability is due to its interaction with RssB, which probably blocks
CC       the interaction of RssB with RpoS, and the consequent delivery of the
CC       RssB-RpoS complex to the ClpXP protein degradation pathway.
CC       {ECO:0000269|PubMed:16938894}.
CC   -!- SUBUNIT: Interacts with RssB. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- INDUCTION: By phosphate starvation and limiting magnesium, via the
CC       transcriptional regulator PhoP and the alarmone ppGpp.
CC       {ECO:0000269|PubMed:16938894}.
CC   -!- SIMILARITY: Belongs to the IraP family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAL19337.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE006468; AAL19337.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; NP_459378.3; NC_003197.2.
DR   AlphaFoldDB; Q7CR46; -.
DR   SMR; Q7CR46; -.
DR   STRING; 99287.STM0383; -.
DR   PaxDb; Q7CR46; -.
DR   DNASU; 1251902; -.
DR   EnsemblBacteria; AAL19337; AAL19337; STM0383.
DR   GeneID; 1251902; -.
DR   KEGG; stm:STM0383; -.
DR   PATRIC; fig|99287.12.peg.406; -.
DR   HOGENOM; CLU_169517_0_0_6; -.
DR   OMA; IDTAMIH; -.
DR   PhylomeDB; Q7CR46; -.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009267; P:cellular response to starvation; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01198; Anti_adapt_IraP; 1.
DR   InterPro; IPR019732; SigmaS_Anti-adapt_IraP.
DR   Pfam; PF10796; Anti-adapt_IraP; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Reference proteome; Stress response.
FT   CHAIN           1..86
FT                   /note="Anti-adapter protein IraP"
FT                   /id="PRO_0000337863"
FT   COILED          1..36
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   86 AA;  9883 MW;  1F904287C95EB24C CRC64;
     MKNLIAELLL KLAQKEEESK ELVAQVEALE IIVTAMLRNM AQNEQEMLIR QVEGALEGVK
     PDASVPDHDT ELLRQYVKKL LRHPRH