IRAS1_HUMAN
ID IRAS1_HUMAN Reviewed; 126 AA.
AC Q8N8D9; A1L3V9; A6NKA0;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 26-FEB-2008, sequence version 2.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Uncharacterized protein IRF1-AS1;
DE AltName: Full=IRF1 antisense RNA 1 {ECO:0000312|HGNC:HGNC:33838};
GN Name=IRF1-AS1 {ECO:0000312|HGNC:HGNC:33838}; Synonyms=C5orf56;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Small intestine;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q8N8D9; A5PKU2: TUSC5; NbExp=3; IntAct=EBI-18100531, EBI-11988865;
CC Q8N8D9; Q9UMX0: UBQLN1; NbExp=3; IntAct=EBI-18100531, EBI-741480;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8N8D9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8N8D9-2; Sequence=VSP_031299;
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DR EMBL; AK096941; BAC04907.1; -; mRNA.
DR EMBL; AK128882; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AC116366; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471062; EAW62334.1; -; Genomic_DNA.
DR EMBL; CH471062; EAW62336.1; -; Genomic_DNA.
DR EMBL; BC130299; AAI30300.1; -; mRNA.
DR EMBL; BC130656; AAI30657.1; -; mRNA.
DR AlphaFoldDB; Q8N8D9; -.
DR IntAct; Q8N8D9; 2.
DR STRING; 9606.ENSP00000338228; -.
DR iPTMnet; Q8N8D9; -.
DR PhosphoSitePlus; Q8N8D9; -.
DR BioMuta; C5orf56; -.
DR PaxDb; Q8N8D9; -.
DR PRIDE; Q8N8D9; -.
DR ProteomicsDB; 72405; -. [Q8N8D9-2]
DR UCSC; uc003kwy.4; human. [Q8N8D9-1]
DR GeneCards; IRF1-AS1; -.
DR HGNC; HGNC:33838; IRF1-AS1.
DR neXtProt; NX_Q8N8D9; -.
DR PharmGKB; PA165660191; -.
DR eggNOG; ENOG502TF5I; Eukaryota.
DR HOGENOM; CLU_2078492_0_0_1; -.
DR InParanoid; Q8N8D9; -.
DR PhylomeDB; Q8N8D9; -.
DR TreeFam; TF353801; -.
DR PathwayCommons; Q8N8D9; -.
DR SignaLink; Q8N8D9; -.
DR ChiTaRS; C5orf56; human.
DR Pharos; Q8N8D9; Tdark.
DR PRO; PR:Q8N8D9; -.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; Q8N8D9; protein.
DR Genevisible; Q8N8D9; HS.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..126
FT /note="Uncharacterized protein IRF1-AS1"
FT /id="PRO_0000318910"
FT VAR_SEQ 30..126
FT /note="GNLQTLLLHWLLLCSCLHHLYNASCHPAFPVEYSHAVCCLQPRFWKEMSPFS
FT SSSTTHLFSKCFFYTCLCWAWQQCSSEQNHQPCSHAAYNQVERQT -> DHLCSLHSRA
FT FGLLDARVTWALRRAPEPVPGKDRLLLAAFPAEASPVDTASVSVYGRAPRYMHKGVKKC
FT VCTPVSKNSTAWLLLGGIS (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_031299"
FT CONFLICT 57
FT /note="A -> T (in Ref. 1; BAC04907)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 126 AA; 14652 MW; ABE0A97EAD2C06C6 CRC64;
MDSLAAGELN ASHQPWVPEF VAYWRKTHQG NLQTLLLHWL LLCSCLHHLY NASCHPAFPV
EYSHAVCCLQ PRFWKEMSPF SSSSTTHLFS KCFFYTCLCW AWQQCSSEQN HQPCSHAAYN
QVERQT
