ID   IRC11_YEAST             Reviewed;         156 AA.
AC   Q12479; O13593;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=Putative increased recombination centers protein 11;
GN   Name=IRC11; OrderedLocusNames=YOR013W; ORFNames=O2612, OR26.03, YOL303.3;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9169874;
RA   Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J.,
RA   Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A.,
RA   Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B.,
RA   Dang V.-D., de Haan M., Delius H., Durand P., Fairhead C., Feldmann H.,
RA   Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E.,
RA   Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U.,
RA   Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B.,
RA   Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A.,
RA   Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C.,
RA   Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G.,
RA   Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B.,
RA   Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B.,
RA   Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F.,
RA   Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E.,
RA   Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I.,
RA   Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H.,
RA   Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV.";
RL   Nature 387:98-102(1997).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [3]
RP   DISRUPTION PHENOTYPE.
RX   PubMed=18085829; DOI=10.1371/journal.pgen.0030228;
RA   Alvaro D., Lisby M., Rothstein R.;
RT   "Genome-wide analysis of Rad52 foci reveals diverse mechanisms impacting
RT   recombination.";
RL   PLoS Genet. 3:E228-E228(2007).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- DISRUPTION PHENOTYPE: Displays increased levels of spontaneous RAD52
CC       foci in proliferating diploid cells. {ECO:0000269|PubMed:18085829}.
CC   -!- MISCELLANEOUS: Partially overlaps YOR012W. Disruption phenotypes caused
CC       by deletion of this gene may also be a result of a defect in its
CC       overlapping gene. {ECO:0000305}.
CC   -!- CAUTION: Product of a dubious gene prediction unlikely to encode a
CC       functional protein. Because of that it is not part of the S.cerevisiae
CC       S288c complete/reference proteome set. {ECO:0000305|PubMed:24374639}.
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DR   EMBL; X87331; CAA60762.1; -; Genomic_DNA.
DR   EMBL; Z74920; CAA99201.1; -; Genomic_DNA.
DR   EMBL; Z74922; CAA99204.1; -; Genomic_DNA.
DR   PIR; S54619; S54619.
DR   AlphaFoldDB; Q12479; -.
DR   SMR; Q12479; -.
DR   DIP; DIP-8966N; -.
DR   IntAct; Q12479; 1.
DR   MINT; Q12479; -.
DR   STRING; 4932.YOR013W; -.
DR   PaxDb; Q12479; -.
DR   PRIDE; Q12479; -.
DR   EnsemblFungi; YOR013W_mRNA; YOR013W; YOR013W.
DR   SGD; S000005539; IRC11.
DR   eggNOG; ENOG502RYMB; Eukaryota.
DR   GeneTree; ENSGT00940000176382; -.
DR   HOGENOM; CLU_142437_0_0_1; -.
DR   InParanoid; Q12479; -.
DR   OMA; MESYHYL; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0006312; P:mitotic recombination; IMP:SGD.
PE   5: Uncertain;
KW   Membrane; Transmembrane; Transmembrane helix.
FT   CHAIN           1..156
FT                   /note="Putative increased recombination centers protein 11"
FT                   /id="PRO_0000299700"
FT   TRANSMEM        20..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   156 AA;  17881 MW;  380442B74C272B41 CRC64;
     MTWMVKLLRQ MISMQSQYGA ALGATCLLHY LTTSLSIRFF FHDLTVRKHE VMPLGMDYYY
     LYAIGKDPSH PEIRGSVRKI LEKYKTKADK ANCALALEAI SEHARSVYEY FGFKTYLVFQ
     FGVGEVNSKG EPDPQGKGFT AYLMLYHKDA DTIFHA