ID   IRC14_YEAST             Reviewed;         113 AA.
AC   Q08522;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 63.
DE   RecName: Full=Putative increased recombination centers protein 14;
GN   Name=IRC14; OrderedLocusNames=YOR135C; ORFNames=O3323;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9169874;
RA   Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J.,
RA   Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A.,
RA   Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B.,
RA   Dang V.-D., de Haan M., Delius H., Durand P., Fairhead C., Feldmann H.,
RA   Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E.,
RA   Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U.,
RA   Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B.,
RA   Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A.,
RA   Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C.,
RA   Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G.,
RA   Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B.,
RA   Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B.,
RA   Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F.,
RA   Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E.,
RA   Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I.,
RA   Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H.,
RA   Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV.";
RL   Nature 387:98-102(1997).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [3]
RP   DISRUPTION PHENOTYPE.
RX   PubMed=18085829; DOI=10.1371/journal.pgen.0030228;
RA   Alvaro D., Lisby M., Rothstein R.;
RT   "Genome-wide analysis of Rad52 foci reveals diverse mechanisms impacting
RT   recombination.";
RL   PLoS Genet. 3:E228-E228(2007).
RN   [4]
RP   DISRUPTION PHENOTYPE.
RX   PubMed=18205808; DOI=10.1111/j.1567-1364.2007.00349.x;
RA   Fong C.S., Temple M.D., Alic N., Chiu J., Durchdewald M., Thorpe G.W.,
RA   Higgins V.J., Dawes I.W.;
RT   "Oxidant-induced cell-cycle delay in Saccharomyces cerevisiae: the
RT   involvement of the SWI6 transcription factor.";
RL   FEMS Yeast Res. 8:386-399(2008).
CC   -!- DISRUPTION PHENOTYPE: Displays increased levels of spontaneous RAD52
CC       foci in proliferating diploid cells and exhibits an absence of G1
CC       checkpoint in response to linoleic acid hydroperoxide (LoaOOH)
CC       treatment. {ECO:0000269|PubMed:18085829, ECO:0000269|PubMed:18205808}.
CC   -!- MISCELLANEOUS: Partially overlaps IDH2. Disruption phenotypes caused by
CC       deletion of this gene may also be a result of a defect in its
CC       overlapping gene. {ECO:0000305}.
CC   -!- CAUTION: Product of a dubious gene prediction unlikely to encode a
CC       functional protein. Because of that it is not part of the S.cerevisiae
CC       S288c complete/reference proteome set. {ECO:0000305|PubMed:24374639}.
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DR   EMBL; Z75043; CAA99334.1; -; Genomic_DNA.
DR   PIR; S67020; S67020.
DR   AlphaFoldDB; Q08522; -.
DR   STRING; 4932.YOR135C; -.
DR   PaxDb; Q08522; -.
DR   PRIDE; Q08522; -.
DR   EnsemblFungi; YOR135C_mRNA; YOR135C; YOR135C.
DR   SGD; S000005661; IRC14.
DR   HOGENOM; CLU_2135476_0_0_1; -.
DR   GO; GO:0030437; P:ascospore formation; HMP:SGD.
DR   GO; GO:0006312; P:mitotic recombination; IMP:SGD.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; HMP:SGD.
PE   5: Uncertain;
FT   CHAIN           1..113
FT                   /note="Putative increased recombination centers protein 14"
FT                   /id="PRO_0000299715"
SQ   SEQUENCE   113 AA;  12545 MW;  3D8C233E6F2BE260 CRC64;
     MVVNPLTKIG LTSQDSHSMG TFAALKIFFT DLEISGPIPS PSMNETVYLP VEGLGLPVYL
     PIEGCFTVAK NLLEVFLKKV FLNIIKKYYN CCSFPICILL STKVIQVQKK CIQ