ID   IRC16_YEAST             Reviewed;         119 AA.
AC   Q6B0V8; A0A8D9PCP4;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 1.
DT   03-AUG-2022, entry version 53.
DE   RecName: Full=Uncharacterized protein IRC16 {ECO:0000305};
DE   AltName: Full=Increased recombination centers protein 16 {ECO:0000303|PubMed:18085829};
GN   Name=IRC16 {ECO:0000303|PubMed:18085829};
GN   OrderedLocusNames=YPR038W {ECO:0000312|SGD:S000006242};
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9169875;
RA   Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W.,
RA   Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D.,
RA   Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E.,
RA   Churcher C.M., Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H.,
RA   DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N.,
RA   Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K.,
RA   Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M.,
RA   Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A.,
RA   Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S.,
RA   Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D.,
RA   Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S.,
RA   Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B.,
RA   Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A.,
RA   Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R.,
RA   Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A.,
RA   Vo D.H., Hani J.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI.";
RL   Nature 387:103-105(1997).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=17322287; DOI=10.1101/gr.6037607;
RA   Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA   Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA   Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA   Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA   LaBaer J.;
RT   "Approaching a complete repository of sequence-verified protein-encoding
RT   clones for Saccharomyces cerevisiae.";
RL   Genome Res. 17:536-543(2007).
RN   [4]
RP   DISRUPTION PHENOTYPE.
RX   PubMed=18085829; DOI=10.1371/journal.pgen.0030228;
RA   Alvaro D., Lisby M., Rothstein R.;
RT   "Genome-wide analysis of Rad52 foci reveals diverse mechanisms impacting
RT   recombination.";
RL   PLoS Genet. 3:E228-E228(2007).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- DISRUPTION PHENOTYPE: Displays increased levels of spontaneous RAD52
CC       foci in proliferating diploid cells. {ECO:0000269|PubMed:18085829}.
CC   -!- MISCELLANEOUS: Partially overlaps ERV2 and YPR039W. Disruption
CC       phenotypes caused by deletion of this gene may also be a result of a
CC       defect in its overlapping gene. {ECO:0000305}.
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DR   EMBL; Z68111; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; Z71255; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BK006949; DAD54812.1; -; Genomic_DNA.
DR   EMBL; AY693322; AAT93341.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q6B0V8; -.
DR   IntAct; Q6B0V8; 1.
DR   PaxDb; Q6B0V8; -.
DR   EnsemblFungi; YPR038W_mRNA; YPR038W; YPR038W.
DR   SGD; S000006242; IRC16.
DR   HOGENOM; CLU_2063316_0_0_1; -.
DR   Proteomes; UP000002311; Chromosome XVI.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0006312; P:mitotic recombination; IMP:SGD.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..119
FT                   /note="Uncharacterized protein IRC16"
FT                   /id="PRO_0000299816"
FT   TRANSMEM        53..73
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        92..112
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   119 AA;  13451 MW;  AA4150DB7CEFB70F CRC64;
     MVCFSISFNR ASFFSAAAPC TSSIPDFALI RPGVAMDSSL DEKNIHRPMI PNAATILMAW
     LLLTICFIPS FLAQSVQTFL FTNHQPSRLL VFITHVYCLM IKPFVLYFWF LFPLRLPGG