IRC19_YEAST
ID IRC19_YEAST Reviewed; 230 AA.
AC Q07843; D6VXX2;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Increased recombination centers protein 19;
DE AltName: Full=Respiratory growth protein 4;
GN Name=IRC19; Synonyms=RRG4; OrderedLocusNames=YLL033W;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169871;
RA Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W.,
RA Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A.,
RA Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K.,
RA Heuss-Neitzel D., Hilbert H., Hilger F., Kleine K., Koetter P., Louis E.J.,
RA Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S.,
RA Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D.,
RA Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M.,
RA Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P.,
RA Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M.,
RA Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K.,
RA Zollner A., Hani J., Hoheisel J.D.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII.";
RL Nature 387:87-90(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [4]
RP INDUCTION.
RX PubMed=9784122; DOI=10.1126/science.282.5389.699;
RA Chu S., DeRisi J., Eisen M., Mulholland J., Botstein D., Brown P.O.,
RA Herskowitz I.;
RT "The transcriptional program of sporulation in budding yeast.";
RL Science 282:699-705(1998).
RN [5]
RP FUNCTION.
RX PubMed=12432101; DOI=10.1073/pnas.202604399;
RA Deutschbauer A.M., Williams R.M., Chu A.M., Davis R.W.;
RT "Parallel phenotypic analysis of sporulation and postgermination growth in
RT Saccharomyces cerevisiae.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:15530-15535(2002).
RN [6]
RP FUNCTION.
RX PubMed=11921089; DOI=10.1002/yea.843.abs;
RA Briza P., Bogengruber E., Thuer A., Ruetzler M., Muensterkoetter M.,
RA Dawes I.W., Breitenbach M.;
RT "Systematic analysis of sporulation phenotypes in 624 non-lethal homozygous
RT deletion strains of Saccharomyces cerevisiae.";
RL Yeast 19:403-422(2002).
RN [7]
RP DISRUPTION PHENOTYPE.
RX PubMed=18085829; DOI=10.1371/journal.pgen.0030228;
RA Alvaro D., Lisby M., Rothstein R.;
RT "Genome-wide analysis of Rad52 foci reveals diverse mechanisms impacting
RT recombination.";
RL PLoS Genet. 3:E228-E228(2007).
RN [8]
RP FUNCTION.
RX PubMed=19751518; DOI=10.1186/gb-2009-10-9-r95;
RA Merz S., Westermann B.;
RT "Genome-wide deletion mutant analysis reveals genes required for
RT respiratory growth, mitochondrial genome maintenance and mitochondrial
RT protein synthesis in Saccharomyces cerevisiae.";
RL Genome Biol. 10:R95.1-R95.18(2009).
CC -!- FUNCTION: Involved in sporulation and maintenance of the mitochondrial
CC DNA. Is probably involved in a pathway contributing to genomic
CC integrity. {ECO:0000269|PubMed:11921089, ECO:0000269|PubMed:12432101,
CC ECO:0000269|PubMed:19751518}.
CC -!- INDUCTION: During sporulation. {ECO:0000269|PubMed:9784122}.
CC -!- DISRUPTION PHENOTYPE: Displays increased levels of spontaneous RAD52
CC foci in proliferating diploid cells. {ECO:0000269|PubMed:18085829}.
CC -!- SIMILARITY: Belongs to the IRC19 family. {ECO:0000305}.
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DR EMBL; Z73138; CAA97482.1; -; Genomic_DNA.
DR EMBL; AY558188; AAS56514.1; -; Genomic_DNA.
DR EMBL; BK006945; DAA09288.1; -; Genomic_DNA.
DR PIR; S64784; S64784.
DR RefSeq; NP_013067.1; NM_001181853.1.
DR AlphaFoldDB; Q07843; -.
DR SMR; Q07843; -.
DR BioGRID; 31220; 128.
DR DIP; DIP-2875N; -.
DR IntAct; Q07843; 3.
DR MINT; Q07843; -.
DR STRING; 4932.YLL033W; -.
DR MaxQB; Q07843; -.
DR PaxDb; Q07843; -.
DR PRIDE; Q07843; -.
DR EnsemblFungi; YLL033W_mRNA; YLL033W; YLL033W.
DR GeneID; 850626; -.
DR KEGG; sce:YLL033W; -.
DR SGD; S000003956; IRC19.
DR VEuPathDB; FungiDB:YLL033W; -.
DR eggNOG; ENOG502S35W; Eukaryota.
DR HOGENOM; CLU_106818_0_0_1; -.
DR InParanoid; Q07843; -.
DR OMA; FMRLKPF; -.
DR BioCyc; YEAST:G3O-32136-MON; -.
DR PRO; PR:Q07843; -.
DR Proteomes; UP000002311; Chromosome XII.
DR RNAct; Q07843; protein.
DR GO; GO:0030437; P:ascospore formation; IMP:SGD.
DR GO; GO:0006312; P:mitotic recombination; IMP:SGD.
DR InterPro; IPR016613; Irc19.
DR PIRSF; PIRSF013329; UCP013329; 1.
PE 2: Evidence at transcript level;
KW Reference proteome; Sporulation.
FT CHAIN 1..230
FT /note="Increased recombination centers protein 19"
FT /id="PRO_0000247128"
SQ SEQUENCE 230 AA; 27378 MW; 4B1D040696A4CF22 CRC64;
MRKPSITITT AKAIITPDYT LIKSHSKYQL PSRFQKLDAD SPERSTVVKL FYRRFMRLKP
FISNVKMVKD TYRDYVRYKF MKENYELKRY LVFNPDGLRS KINLELLSNT KCCERILPVT
EMQRTLEFVL KSCSYLPETK VQKWDIARDN TYCRQILKNL LTMQYEKYRS ILHRGIGHDE
LDVKFSHLKT TSSPLTKLNK TEKKKIPLFK VFSDFDTTLI YLNETLGTRL
