ID   IRC22_ASHGO             Reviewed;         220 AA.
AC   Q8J1F5; Q75AB8;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Increased recombination centers protein 22;
DE   Flags: Precursor;
GN   Name=IRC22; OrderedLocusNames=ADL001C;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Is probably involved in a pathway contributing to genomic
CC       integrity.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Single-pass type I membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IRC22 family. {ECO:0000305}.
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DR   EMBL; AF384990; AAO16964.1; -; Genomic_DNA.
DR   EMBL; AE016817; AAS51920.1; -; Genomic_DNA.
DR   RefSeq; NP_984096.1; NM_209449.1.
DR   AlphaFoldDB; Q8J1F5; -.
DR   STRING; 33169.AAS51920; -.
DR   EnsemblFungi; AAS51920; AAS51920; AGOS_ADL001C.
DR   GeneID; 4620244; -.
DR   KEGG; ago:AGOS_ADL001C; -.
DR   eggNOG; ENOG502S3VP; Eukaryota.
DR   HOGENOM; CLU_078554_1_0_1; -.
DR   InParanoid; Q8J1F5; -.
DR   OMA; YQEEWIP; -.
DR   Proteomes; UP000000591; Chromosome IV.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; Membrane; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..220
FT                   /note="Increased recombination centers protein 22"
FT                   /id="PRO_0000399069"
FT   TOPO_DOM        20..166
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        167..186
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        187..220
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   220 AA;  24593 MW;  F6926C2A221569CB CRC64;
     MKLSNLLLFA NVGTLLVKAT DENISPNEEN TPRYAQFNID YSVLDQPNYD PMAPMEFENG
     ENITLAFNFA NNEEVPVKLI AVGGNIINAR SGDEVANITR SSLGEIEVDV NTSVSFNQAI
     NLKLDEGDYF LLPNVFVLKE GELMAVGTSP SRIKILPPPM SFFNPKFLSI QAVLIGVISY
     FTYFIFRSSK KERRGVVSKT KAPKKVKLDE SWLPENHLKK