ID   IRC22_CANDC             Reviewed;         237 AA.
AC   B9WCP3;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   24-MAR-2009, sequence version 1.
DT   03-AUG-2022, entry version 39.
DE   RecName: Full=Increased recombination centers protein 22;
DE   Flags: Precursor;
GN   Name=IRC22; ORFNames=CD36_23860, CD36_24080;
OS   Candida dubliniensis (strain CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 /
OS   NRRL Y-17841) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=573826;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 / NRRL Y-17841;
RX   PubMed=19745113; DOI=10.1101/gr.097501.109;
RA   Jackson A.P., Gamble J.A., Yeomans T., Moran G.P., Saunders D., Harris D.,
RA   Aslett M., Barrell J.F., Butler G., Citiulo F., Coleman D.C.,
RA   de Groot P.W.J., Goodwin T.J., Quail M.A., McQuillan J., Munro C.A.,
RA   Pain A., Poulter R.T., Rajandream M.A., Renauld H., Spiering M.J.,
RA   Tivey A., Gow N.A.R., Barrell B., Sullivan D.J., Berriman M.;
RT   "Comparative genomics of the fungal pathogens Candida dubliniensis and
RT   Candida albicans.";
RL   Genome Res. 19:2231-2244(2009).
CC   -!- FUNCTION: Is probably involved in a pathway contributing to genomic
CC       integrity.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Single-pass type I membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IRC22 family. {ECO:0000305}.
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DR   EMBL; FM992689; CAX44166.1; -; Genomic_DNA.
DR   EMBL; FM992689; CAX44188.1; -; Genomic_DNA.
DR   RefSeq; XP_002418860.1; XM_002418815.1.
DR   RefSeq; XP_002418882.1; XM_002418837.1.
DR   AlphaFoldDB; B9WCP3; -.
DR   STRING; 42374.XP_002418860.1; -.
DR   EnsemblFungi; CAX44166; CAX44166; CD36_23860.
DR   EnsemblFungi; CAX44188; CAX44188; CD36_24080.
DR   GeneID; 8046395; -.
DR   GeneID; 8046415; -.
DR   KEGG; cdu:CD36_23860; -.
DR   KEGG; cdu:CD36_24080; -.
DR   CGD; CAL0000167620; Cd36_23860.
DR   CGD; CAL0000161564; Cd36_24080.
DR   VEuPathDB; FungiDB:CD36_23860; -.
DR   VEuPathDB; FungiDB:CD36_24080; -.
DR   eggNOG; ENOG502S7BF; Eukaryota.
DR   HOGENOM; CLU_078554_0_0_1; -.
DR   OrthoDB; 1349929at2759; -.
DR   Proteomes; UP000002605; Chromosome 2.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; Membrane; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..237
FT                   /note="Increased recombination centers protein 22"
FT                   /id="PRO_0000399074"
FT   TOPO_DOM        20..161
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        162..182
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        183..237
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          198..219
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   237 AA;  25842 MW;  33D95228790DA04A CRC64;
     MKLSTIFTVF AATIATVAGY ETTGSKQTVD ILIDYVIKET PELSQNDVAN WENGDTVTLQ
     YVVNNNEETE ITVVGVTGQF KNPINNEIVT NLTTGKVGPI AVPPGEAIKF DQKINVDLIP
     ANYELIPHVF IAQDSLIKVI PCRGQLATIV DAAVSFFDPR LIFLELVLLV TFAGLLYVGY
     EIWGKQYFKS VAPVKAKKTS TKASSPVASA STSAATGYDT NWIPESHLKQ KKTKKVN