ID   IRC22_CANGA             Reviewed;         245 AA.
AC   Q6FLM2;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Increased recombination centers protein 22;
DE   Flags: Precursor;
GN   Name=IRC22; OrderedLocusNames=CAGL0L02343g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Is probably involved in a pathway contributing to genomic
CC       integrity.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Single-pass type I membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IRC22 family. {ECO:0000305}.
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DR   EMBL; CR380958; CAG61842.1; -; Genomic_DNA.
DR   RefSeq; XP_448872.1; XM_448872.1.
DR   AlphaFoldDB; Q6FLM2; -.
DR   STRING; 5478.XP_448872.1; -.
DR   EnsemblFungi; CAG61842; CAG61842; CAGL0L02343g.
DR   GeneID; 2890902; -.
DR   KEGG; cgr:CAGL0L02343g; -.
DR   CGD; CAL0136006; CAGL0L02343g.
DR   VEuPathDB; FungiDB:CAGL0L02343g; -.
DR   eggNOG; ENOG502S3VP; Eukaryota.
DR   HOGENOM; CLU_078554_1_0_1; -.
DR   InParanoid; Q6FLM2; -.
DR   OMA; YQEEWIP; -.
DR   Proteomes; UP000002428; Chromosome L.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; Membrane; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..245
FT                   /note="Increased recombination centers protein 22"
FT                   /id="PRO_0000399075"
FT   TOPO_DOM        21..188
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        189..209
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        210..245
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   245 AA;  27360 MW;  62A3128C3F5FE4EE CRC64;
     MKFLHIGLMT LMAGVSNVLA QEEANAEDVM VNIEGQDMTM EEAEAYMAAK EKMGGAQQQR
     EMINLQVNYD LLEEPFADLQ DFIVFEVGET ATLNYTIHNL DQEETYSIVG VSGAVLSEVD
     QRNVANLTET NITEIVLAPN ATGTLRHKID MNLTEGRYYI LPLLHVKDKN EVKRVMSNTF
     KLDLINQSIS IFDPSFLSII AVLIALVGGT VYLYSNVVAP PKKIKKKEAI PAKIDESWLP
     DVHKK