IRC22_KLULA
ID IRC22_KLULA Reviewed; 238 AA.
AC Q6CQW1;
DT 05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 25-MAY-2022, entry version 65.
DE RecName: Full=Increased recombination centers protein 22;
DE Flags: Precursor;
GN Name=IRC22; OrderedLocusNames=KLLA0D13816g;
OS Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX NCBI_TaxID=284590;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: Is probably involved in a pathway contributing to genomic
CC integrity.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC Single-pass type I membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the IRC22 family. {ECO:0000305}.
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DR EMBL; CR382124; CAH00774.1; -; Genomic_DNA.
DR RefSeq; XP_453678.1; XM_453678.1.
DR AlphaFoldDB; Q6CQW1; -.
DR STRING; 28985.XP_453678.1; -.
DR EnsemblFungi; CAH00774; CAH00774; KLLA0_D13816g.
DR GeneID; 2892972; -.
DR KEGG; kla:KLLA0_D13816g; -.
DR eggNOG; ENOG502S3VP; Eukaryota.
DR HOGENOM; CLU_078554_1_0_1; -.
DR InParanoid; Q6CQW1; -.
DR OMA; YQEEWIP; -.
DR Proteomes; UP000000598; Chromosome D.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE 3: Inferred from homology;
KW Endoplasmic reticulum; Membrane; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..238
FT /note="Increased recombination centers protein 22"
FT /id="PRO_0000399079"
FT TOPO_DOM 19..191
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 192..212
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 213..238
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 219..238
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 238 AA; 26388 MW; 4F1C3E127CBFE3EA CRC64;
MKFLKVALIF SALSGVYADL EHNLRIHNDI PVEYDSDAAS ADIGSEDEPH QQEPKIANFL
IEYDVLEEDG RISSGLIEVE NGKSLSFSYN FTNSEDADVN VYAFGGSIID MGSSQIIADI
PRTDFSPVHV AINESARLLQ KLPIDLPEGI LYVLPHIYVD KDGEQMKVGA SPISIQVVPP
PLSIFNPQFL SIQLFLLGLV AAISYYVFGF SFKTTKQPVK KQNRASNSNE WLPETHIK
