ID   IRC22_KOMPG             Reviewed;         223 AA.
AC   C4R0M5;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   07-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 44.
DE   RecName: Full=Increased recombination centers protein 22;
DE   Flags: Precursor;
GN   Name=IRC22; OrderedLocusNames=PAS_chr2-1_0426;
OS   Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Phaffomycetaceae; Komagataella.
OX   NCBI_TaxID=644223;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GS115 / ATCC 20864;
RX   PubMed=19465926; DOI=10.1038/nbt.1544;
RA   De Schutter K., Lin Y.-C., Tiels P., Van Hecke A., Glinka S.,
RA   Weber-Lehmann J., Rouze P., Van de Peer Y., Callewaert N.;
RT   "Genome sequence of the recombinant protein production host Pichia
RT   pastoris.";
RL   Nat. Biotechnol. 27:561-566(2009).
CC   -!- FUNCTION: Is probably involved in a pathway contributing to genomic
CC       integrity.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Single-pass type I membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IRC22 family. {ECO:0000305}.
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DR   EMBL; FN392320; CAY69049.1; -; Genomic_DNA.
DR   RefSeq; XP_002491329.1; XM_002491284.1.
DR   AlphaFoldDB; C4R0M5; -.
DR   STRING; 644223.C4R0M5; -.
DR   EnsemblFungi; CAY69049; CAY69049; PAS_chr2-1_0426.
DR   GeneID; 8198894; -.
DR   KEGG; ppa:PAS_chr2-1_0426; -.
DR   eggNOG; ENOG502S7BF; Eukaryota.
DR   HOGENOM; CLU_078554_0_0_1; -.
DR   InParanoid; C4R0M5; -.
DR   OMA; YQEEWIP; -.
DR   Proteomes; UP000000314; Chromosome 2.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; Membrane; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..223
FT                   /note="Increased recombination centers protein 22"
FT                   /id="PRO_0000399083"
FT   TOPO_DOM        24..171
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        172..192
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        193..223
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          204..223
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   223 AA;  24758 MW;  52D33D0145C10B92 CRC64;
     MKFLRLSTLA LVGLGFLTQT TLCDPDTDEE FVPTEQKPFN IRVTYEIDEH PQSFESTKLI
     ELVNGEEISV TYNIKNGEDE SVSVVGVAGS FNDPVTGLTK RNLTASSVGP LKLLKDMTFE
     FTQKIGIDLE PENYLFVPSI YVLKDDQLML LGSKNQLITV SDPQISVFQP QMLFLELVLL
     ASFGGLIYAL YATFGASYFQ KPATAPKNKK VGSSNVRKTK KNK