ID   IRC22_LACTC             Reviewed;         221 AA.
AC   C5DJ31;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 48.
DE   RecName: Full=Increased recombination centers protein 22;
DE   Flags: Precursor;
GN   Name=IRC22; OrderedLocusNames=KLTH0F13046g;
OS   Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284)
OS   (Yeast) (Kluyveromyces thermotolerans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Lachancea.
OX   NCBI_TaxID=559295;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 56472 / CBS 6340 / NRRL Y-8284;
RX   PubMed=19525356; DOI=10.1101/gr.091546.109;
RG   The Genolevures Consortium;
RA   Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V.,
RA   Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P., Jubin C.,
RA   Poulain J., Barbe V., Segurens B., Artiguenave F., Anthouard V.,
RA   Vacherie B., Val M.-E., Fulton R.S., Minx P., Wilson R., Durrens P.,
RA   Jean G., Marck C., Martin T., Nikolski M., Rolland T., Seret M.-L.,
RA   Casaregola S., Despons L., Fairhead C., Fischer G., Lafontaine I., Leh V.,
RA   Lemaire M., de Montigny J., Neuveglise C., Thierry A., Blanc-Lenfle I.,
RA   Bleykasten C., Diffels J., Fritsch E., Frangeul L., Goeffon A.,
RA   Jauniaux N., Kachouri-Lafond R., Payen C., Potier S., Pribylova L.,
RA   Ozanne C., Richard G.-F., Sacerdot C., Straub M.-L., Talla E.;
RT   "Comparative genomics of protoploid Saccharomycetaceae.";
RL   Genome Res. 19:1696-1709(2009).
CC   -!- FUNCTION: Is probably involved in a pathway contributing to genomic
CC       integrity.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Single-pass type I membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IRC22 family. {ECO:0000305}.
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DR   EMBL; CU928170; CAR24320.1; -; Genomic_DNA.
DR   RefSeq; XP_002554757.1; XM_002554711.1.
DR   AlphaFoldDB; C5DJ31; -.
DR   STRING; 559295.C5DJ31; -.
DR   EnsemblFungi; CAR24320; CAR24320; KLTH0F13046g.
DR   GeneID; 8292980; -.
DR   KEGG; lth:KLTH0F13046g; -.
DR   eggNOG; ENOG502S3VP; Eukaryota.
DR   HOGENOM; CLU_078554_1_0_1; -.
DR   InParanoid; C5DJ31; -.
DR   OMA; YQEEWIP; -.
DR   OrthoDB; 1349929at2759; -.
DR   Proteomes; UP000002036; Chromosome F.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; Membrane; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..221
FT                   /note="Increased recombination centers protein 22"
FT                   /id="PRO_0000399080"
FT   TOPO_DOM        20..165
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        166..186
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        187..221
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          193..221
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   221 AA;  24497 MW;  855D8EEBFBE9C8C3 CRC64;
     MKFSGIQVSI LALLRVCLAE ADSGEGNQEA LPHANFDITY ECLERDVGGL SSFMEFENGD
     NATLQYKFTN KEDLNVSVVG LGGRIYDVQK NEDAANISAS AIGPLDVDVN GTTEFQHVIK
     LVLKEGDYVL SPDVYVQKEN ETMRVVTNPS LIRILPPPMS FFNPKFMLVQ MVLGALIAAF
     SYFTFFKPSA SYGRDAKKLK PDGSVSRMDS SWLPENHQKK K