ID   IRC22_LODEL             Reviewed;         239 AA.
AC   A5DYV2;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 1.
DT   03-AUG-2022, entry version 46.
DE   RecName: Full=Increased recombination centers protein 22;
DE   Flags: Precursor;
GN   Name=IRC22; ORFNames=LELG_02539;
OS   Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC
OS   1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade;
OC   Lodderomyces.
OX   NCBI_TaxID=379508;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 11503 / BCRC 21390 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL
RC   YB-4239;
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA   Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA   Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA   Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA   Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA   Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA   Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA   Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA   Birren B.W., Kellis M., Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
CC   -!- FUNCTION: Is probably involved in a pathway contributing to genomic
CC       integrity.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Single-pass type I membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IRC22 family. {ECO:0000305}.
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DR   EMBL; CH981526; EDK44360.1; -; Genomic_DNA.
DR   RefSeq; XP_001525981.1; XM_001525931.1.
DR   AlphaFoldDB; A5DYV2; -.
DR   STRING; 379508.A5DYV2; -.
DR   EnsemblFungi; EDK44360; EDK44360; LELG_02539.
DR   GeneID; 5232897; -.
DR   KEGG; lel:LELG_02539; -.
DR   VEuPathDB; FungiDB:LELG_02539; -.
DR   eggNOG; ENOG502S7BF; Eukaryota.
DR   HOGENOM; CLU_078554_0_0_1; -.
DR   InParanoid; A5DYV2; -.
DR   OMA; YQEEWIP; -.
DR   OrthoDB; 1349929at2759; -.
DR   Proteomes; UP000001996; Unassembled WGS sequence.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; Membrane; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..239
FT                   /note="Increased recombination centers protein 22"
FT                   /id="PRO_0000399081"
FT   TOPO_DOM        20..160
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        161..181
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        182..239
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   239 AA;  25949 MW;  8AA60039DCA4FE63 CRC64;
     MKVFTLLAAA AASIATVVGY ETAEKQFVDI LIEYQIVQTP EVTKNDVAQW TNGDEVTLKY
     NIVNNEEKEV TVIGVTGQFT NPVTNEIVTN LTQGRVGPLS IPPGQSASFE QNIGIDVIPN
     NYELIPQVFF AHDELIKVIP CRGQLATVAD KSISFFDPRL IFLELVLLAS FAGIAYLAYQ
     IWGKKYIQGT APVKVKKTTA VTSVPAGTGV STTTTGASGY DVNWIPEGHL KQKKTKKVA